Quantum applications increasingly execute as multi-stage quantum-classical pipelines, interleaving QPU computation with classical stages like circuit generation, transpilation, layout mapping, quantum error mitigation (QEM), and post-processing. These stages have diverse resource requirements and exhibit stochastic behavior under drifting hardware noises, yet existing workflow frameworks treat them as static, isolated components. We present LLQM (Low-Level Quantum Machine), a profiling-driven meta-framework for quantum-classical pipelines. LLQM decomposes pipelines into fine-grained tasks and continuously profiles their CPU/GPU, memory, QPU, and queue dependencies alongside real-time hardware states. This unified runtime abstraction captures cross-stage resource dependencies and reveals how classical and quantum decisions interact, enabling characterization of their impact on fidelity and resource consumption. We evaluate LLQM using QEM as a representative pipeline stage, on IBM 156-qubit Heron r2 processors with circuits up to 100 qubits and 1e7 transpiled gates. Our results show that continuous profiling exposes runtime bottlenecks and enables hardware-, fidelity-, and workload-aware optimizations.
Quantum applications increasingly execute as multi-stage quantum-classical pipelines, interleaving QPU computation with classical stages like circuit generation, transpilation, layout mapping, quantum error mitigation (QEM), and post-processing. These stages have diverse resource requirements and exhibit stochastic behavior under drifting hardware noises, yet existing workflow frameworks treat them as static, isolated components. We present LLQM (Low-Level Quantum Machine), a profiling-driven meta-framework for quantum-classical pipelines. LLQM decomposes pipelines into fine-grained tasks and continuously profiles their CPU/GPU, memory, QPU, and queue dependencies alongside real-time hardware states. This unified runtime abstraction captures cross-stage resource dependencies and reveals how classical and quantum decisions interact, enabling characterization of their impact on fidelity and resource consumption. We evaluate LLQM using QEM as a representative pipeline stage, on IBM 156-qubit Heron r2 processors with circuits up to 100 qubits and 1e7 transpiled gates. Our results show that continuous profiling exposes runtime bottlenecks and enables hardware-, fidelity-, and workload-aware optimizations.
Quantum processors are being integrated into HPC ecosystems as co-processors, where compilation of quantum circuits into hardware-executable form determines both output fidelity and runtime. Current compilers use a fixed pass sequence and ignore the fact that optimal pass selection varies with circuit, hardware, and noise conditions. We present TuniQ, a reinforcement learning-based system that selects compilation passes at each pipeline stage, adapting to circuit, backend, and current noise profile. TuniQ introduces several novel design components like a dual-encoder for stage-aware representation, shaped rewards for cross-stage credit assignment, and dynamic action masking for valid compilation. Evaluated across diverse quantum workloads on multiple IBM Quantum Cloud processors, TuniQ improves fidelity and reduces compilation time over the state-of-the-art IBM Qiskit transpiler, generalizes across backends without retraining, and scales strongly to utility-scale circuits with growing advantage.
Quantum computers are the next evolution of computing hardware. Quantum devices are being exposed through the same familiar cloud platforms used for classical computers, and enabling seamless execution of hybrid applications that combine quantum and classical components. Quantum devices vary in features, e.g., number of qubits, quantum volume, CLOPS, noise profile, queuing delays and resource cost. So, it may be useful to split hybrid workloads with either large quantum circuits or a large number of quantum circuits, into smaller units. In this paper, we profile two workload splitting techniques on IBM's Quantum Cloud: (1) Circuit parallelization, to split one large circuit into multiple smaller ones, and (2) Data parallelization to split a large number of circuits that run on one device to smaller batches of circuits that run on concurrently on multiple devices. These can improve the utilization of heterogeneous quantum hardware, but involve trade-offs. We evaluate these techniques on two key algorithmic classes: Variational Quantum Eigensolver (VQE) and Quantum Support Vector Machine (QSVM), and measure the impact on quality of the result, circuit execution times, quantum resource usage, and processing overheads, relative to a baseline without such parallelization. The results are obtained on real hardware and complemented by simulations. We see that (1) VQE with circuit cutting is ~ 39% better in ground state estimation than the uncut version, and (2) QSVM that combines data parallelization with a reduced feature set yields upto 3 ×improvement in quantum workload execution time and reduces quantum resource use by 3 ×, while providing comparable accuracy. Error mitigation can improve the accuracy by ≈ 7% and reduce resource footprint by ≈4% compared to the best case among the considered scenarios.
Hybrid quantum-classical workflows combine quantum processing units (QPUs) with classical hardware to address computational tasks that are challenging or infeasible for conventional systems alone. Coordinating these heterogeneous resources at scale demands robust orchestration, reproducibility, and observability. Even in the presence of fault-tolerant quantum devices, quantum computing will continue to operate within a broader hybrid ecosystem, where classical infrastructure plays a central role in task scheduling, data movement, error mitigation, and large-scale workflow coordination.
In this work, we present a cloud-native framework for managing hybrid quantum-HPC pipelines using Kubernetes, Argo Workflows, and Kueue. Our system unifies CPUs, GPUs, and QPUs under a single orchestration layer, enabling multi-stage workflows with dynamic, resource-aware scheduling. We demonstrate the framework with a proof-of-concept implementation of distributed quantum circuit cutting, showcasing execution across heterogeneous nodes and integration of classical and quantum tasks. This approach highlights the potential for scalable, reproducible, and flexible hybrid quantum-classical computing in cloud-native environments.
Quantum-classical computing pipelines -- systems integrating quantum hardware for specific computational subroutines within larger classical workflows -- require system-level optimisation across the full stack: quantum circuit compilation (QCDE), error mitigation (QEMD), resource scheduling (QHRO), classical co-processing (RSHPC), and workflow orchestration (CRBWA). Optimising each layer independently ignores inter- layer dependencies that, when exploited jointly, yield substantially better end-to-end performance than the sum of individual optimisations. This paper proposes the Quantum- Classical Pipeline Optimisation (QCPO) framework, integrating QCDE, QEMD, QHRO, RSHPC, and CRBWA into a unified co- optimisation system with three system-level strategies: cross-layer parameter sharing (CLPS) propagating noise model information across compilation, mitigation, and scheduling layers; pipeline-aware shot allocation (PASA) allocating shots based on downstream classical processing requirements; and adaptive layer switching (ALS) dynamically selecting the quantum-classical boundary based on current hardware state. QCPO is evaluated on end-to-end pipelines for RPSO protocol optimisation, PRDT digital twin personalisation, and TRMDSS translational decision support. QCPO reduces total pipeline cost by 58.4% and end-to-end latency by 48.4% vs. independently-optimised layers on identical hardware.
Hybrid quantum-classical performance depends on how quantum processors share classical compute, controllers, memory, and communication links. Circuit simulators and provider measurements expose kernel and job behavior, but leave topology-level questions about controller bottlenecks, quantum capacity, and mixed-workload contention unanswered. We present HybridQC, a discrete-event simulator for configurable hybrid compute units (HCUs). Users specify resource graphs containing classical compute, memory, controllers, quantum annealing (QA) and digital quantum computing (DQC) devices, and links. Jobs become dependent stages for preparation, quantum execution, transfers, reconstruction, and postprocessing. Finite capacities and selectable scheduling policies determine where stages wait and overlap. Service profiles use measurements from D-Wave Advantage 1 and Advantage 2 and IBM Kingston, Marrakesh, and Fez, separating physical quantum-processor occupancy from cloud wall time. Mean absolute percentage errors are 3.92%-8.04% for D-Wave access time and 5.26%-19.01% for IBM quantum seconds. Balanced 10x HCU scaling improves makespan by 2.19x-3.42x, while policy choice changes makespan by 1.80x for a mixed workload with 20 jobs per workload family. Scaling depends on which inputs grow: 100x data growth yields median runtime near 306 s, while 100x joint growth in circuits, shots, and depth reaches 4.806 x 10^7 s on the fixed HCU. HybridQC enables designers to study topology, scheduling, and workload growth before tightly integrated quantum-classical machines exist physically.
Abstract Quantum computing has recently emerged as a novel paradigm for solving problems otherwise intractable on classical computers, yet the practical progress of quantum computers is severely impacted by noise, decoherence, and imperfect gate operations in Noisy Intermediate-Scale Quantum (NISQ) devices. Specific to IBM Quantum hardware, imperfections due to readout error, gate errors, and device drift, which depends on time, resolves limits for the accuracy of outputs from our algorithms. The mitigation strategies currently used, for example, Measurement Error Mitigation (MEM), Zero Noise Extrapolation (ZNE), and Clifford Data Regression (CDR), offer improvement over raw, unmitigated outputs, but they are static and not dynamic; the reduction of noise in within an NISQ device is temporal and can vary in patterns that are non-zero. In addition to this, using the conventional methods provides inconsistent and suboptimal results.This study will provide enhanced reliability with respect to performing quantum computation on IBM Quantum hardware with a unique mitigation framework that is adaptive and computationally efficient for a high-fidelity output. The problem taken on here is the failure of existing error mitigation strategies to provide adaptive noise compensation, as they assume a statically-distributed error, despite the performance-related characteristics already being documented in regards to calibration drift and variation over time.To achieve this, we propose a Hybrid Adaptive Error Mitigation (HAEM) approach that includes baseline measurement error mitigation and an additional correction layer that utilizes realtime calibration information, along with lightweight machine learning models. The approach can be broken down into three steps: (i) perform standard measurement error mitigation to reduce classical readout noise, (ii) execute compact calibration circuits, such as Bell states, GHZ states and Clifford benchmarks to capture then current error profile of the device, and (iii) use a lightweight machine learning model (having been trained on historical and newest calibration data) to dynamically change the mitigation weights applied for the target quantum algorithm. All implementation is done using Qiskit Runtime to ensure low-latency execution, and we completed experiments on both Qiskit Aer noisy simulators and IBM Quantum devices.Initial results suggest HAEM improved the outputs of quantum algorithms' fidelity compared to the unmitigated runs and the baseline measurement error mitigation (MEM) runs. On the noisy simulators, HAEM increased fidelity from a raw performance of 0.65 to 0.87, nearly a 34% improvement. In fairer hardware-like scenarios, fidelity-on-average was persistently 12% better than MEM, with nearly equal time duration for the additional adaptive measurements. The adaptive aspect of HAEM consistently supported subsequent calibration cycles of the device and was effective to continue providing fidelity improvements despite the static mitigation performance degrading.To sum up, the proposed HAEM framework is a modern and viable alternative for error mitigation which brings together the benefits of baseline approaches with corrections that are driven by fixed-function error-corrective, adaptive learning. As both learning-based and standard baseline approaches can only achieve fixed levels of performance, HAEM, through its use of noise mitigation both at execution time and through correlating it with standard data, provides a route towards reliable quantum computations on current IBM hardware. HAEM also presents a contribution to the NISQ error-resilient landscape, and however it is intended that it will continue to improve future applications of hybrid workflows of quantum and classical computation where error mitigation and resilience is important.