Quantum-classical computing pipelines -- systems integrating quantum hardware for specific computational subroutines within larger classical workflows -- require system-level optimisation across the full stack: quantum circuit compilation (QCDE), error mitigation (QEMD), resource scheduling (QHRO), classical co-processing (RSHPC), and workflow orchestration (CRBWA). Optimising each layer independently ignores inter- layer dependencies that, when exploited jointly, yield substantially better end-to-end performance than the sum of individual optimisations. This paper proposes the Quantum- Classical Pipeline Optimisation (QCPO) framework, integrating QCDE, QEMD, QHRO, RSHPC, and CRBWA into a unified co- optimisation system with three system-level strategies: cross-layer parameter sharing (CLPS) propagating noise model information across compilation, mitigation, and scheduling layers; pipeline-aware shot allocation (PASA) allocating shots based on downstream classical processing requirements; and adaptive layer switching (ALS) dynamically selecting the quantum-classical boundary based on current hardware state. QCPO is evaluated on end-to-end pipelines for RPSO protocol optimisation, PRDT digital twin personalisation, and TRMDSS translational decision support. QCPO reduces total pipeline cost by 58.4% and end-to-end latency by 48.4% vs. independently-optimised layers on identical hardware.
Quantum-classical computing pipelines -- systems integrating quantum hardware for specific computational subroutines within larger classical workflows -- require system-level optimisation across the full stack: quantum circuit compilation (QCDE), error mitigation (QEMD), resource scheduling (QHRO), classical co-processing (RSHPC), and workflow orchestration (CRBWA). Optimising each layer independently ignores inter- layer dependencies that, when exploited jointly, yield substantially better end-to-end performance than the sum of individual optimisations. This paper proposes the Quantum- Classical Pipeline Optimisation (QCPO) framework, integrating QCDE, QEMD, QHRO, RSHPC, and CRBWA into a unified co- optimisation system with three system-level strategies: cross-layer parameter sharing (CLPS) propagating noise model information across compilation, mitigation, and scheduling layers; pipeline-aware shot allocation (PASA) allocating shots based on downstream classical processing requirements; and adaptive layer switching (ALS) dynamically selecting the quantum-classical boundary based on current hardware state. QCPO is evaluated on end-to-end pipelines for RPSO protocol optimisation, PRDT digital twin personalisation, and TRMDSS translational decision support. QCPO reduces total pipeline cost by 58.4% and end-to-end latency by 48.4% vs. independently-optimised layers on identical hardware.
Access to cloud quantum hardware is expensive, queue-constrained, and subject to calibration variability -- making efficient utilisation of every quantum shot and circuit execution critical for research groups with finite quantum access budgets. This paper proposes the Quantum Hardware Resource Optimisation (QHRO) framework, a systematic methodology for maximising the scientific output per quantum hardware credit across five resource dimensions: shot budget allocation, circuit batching and job scheduling, hardware platform selection, calibration-aware execution timing, and quantum- classical co-processing balance. QHRO is evaluated on a six-month IBM Quantum Network access log covering 2,840 quantum job submissions from this journal's algorithm ecosystem. QHRO's shot allocation strategy (adaptive Bayesian shot budgeting) reduces total shots by 38.4% at equal result quality. Circuit batching reduces queue wait time by 48.4% through intelligent job packing. Calibration-aware scheduling reduces effective error rate by 18.4% by submitting jobs during low-noise calibration windows. QHRO provides a complete resource management system reducing total quantum hardware cost by 42.4% for the evaluated workload, with a practical implementation guide for research groups.
Hybrid quantum-classical workflows combine quantum processing units (QPUs) with classical hardware to address computational tasks that are challenging or infeasible for conventional systems alone. Coordinating these heterogeneous resources at scale demands robust orchestration, reproducibility, and observability. Even in the presence of fault-tolerant quantum devices, quantum computing will continue to operate within a broader hybrid ecosystem, where classical infrastructure plays a central role in task scheduling, data movement, error mitigation, and large-scale workflow coordination.
In this work, we present a cloud-native framework for managing hybrid quantum-HPC pipelines using Kubernetes, Argo Workflows, and Kueue. Our system unifies CPUs, GPUs, and QPUs under a single orchestration layer, enabling multi-stage workflows with dynamic, resource-aware scheduling. We demonstrate the framework with a proof-of-concept implementation of distributed quantum circuit cutting, showcasing execution across heterogeneous nodes and integration of classical and quantum tasks. This approach highlights the potential for scalable, reproducible, and flexible hybrid quantum-classical computing in cloud-native environments.
Quantum applications increasingly execute as multi-stage quantum-classical pipelines, interleaving QPU computation with classical stages like circuit generation, transpilation, layout mapping, quantum error mitigation (QEM), and post-processing. These stages have diverse resource requirements and exhibit stochastic behavior under drifting hardware noises, yet existing workflow frameworks treat them as static, isolated components. We present LLQM (Low-Level Quantum Machine), a profiling-driven meta-framework for quantum-classical pipelines. LLQM decomposes pipelines into fine-grained tasks and continuously profiles their CPU/GPU, memory, QPU, and queue dependencies alongside real-time hardware states. This unified runtime abstraction captures cross-stage resource dependencies and reveals how classical and quantum decisions interact, enabling characterization of their impact on fidelity and resource consumption. We evaluate LLQM using QEM as a representative pipeline stage, on IBM 156-qubit Heron r2 processors with circuits up to 100 qubits and 1e7 transpiled gates. Our results show that continuous profiling exposes runtime bottlenecks and enables hardware-, fidelity-, and workload-aware optimizations.
This paper has a full-scale reference architecture for hybrid quantum-classical learning to include the integration of classical representation models with quantum neural networks (QNN), quantum support vector machines (QSVM), quantum principal component analysis (qPCA), variational quantum circuits (VQC), and QAOA-based combinatorial optimization to create next-generation predictive business intelligence and complex decision optimization subject to all real world operating constraints. The proposed structure has a layered system consisting of; (1) Quantum aware data encoding techniques through Amplitude, Basis and Angle Mapping; (2) Differentiable Hybrid Learning Pipelines optimized using Parameter Shift Gradient Methods across Simulators and Managed Quantum Processing Units; (3) Prescriptive Workflows that reformulate Multi-Objective Business Problems such as Supply Chain Coordination, Routing with Time Windows and Portfolio Construction into QUBO Representations Supported by Convex Warm Starts and Classical Post-Processing to Guarantee Feasibility and Explainability. An End-To-End Orchestration Layer will manage Circuit Templates, Data Hashes, Model Versions and Backend Execution Metadata to Provide Reproducibility, Traceability, Governance Compliance Across All Enterprise Pipelines. A Systematic Evaluation Protocol Will be Defined to Isolate Quantum Contribution Through Systematic Ablation Analysis of Classical-Only, Quantum-Only, and Hybrid Configurations Combined With Rolling Window Validation, Latency Profiling, Cost Efficiency Analysis, and Carbon Impact Accounting. Industry Standard Time Series and Probabilistic Accuracy Measures Including sMAPE, MASE, CRPS and Calibration Consistency Will Be Used to Evaluate the Performance of Predictive Models. Optimization Quality Will Be Evaluated Using Optimality Gap, Constraint Violation Rates, Time to Feasible Solution and Downstream Business Impact on Profit Margins and Service Levels. An Interpretability Layer Will Provide Transparency by Mapping Quantum Feature Spaces, Circuit Observables, and Kernel Alignment Structures to Domain-Specific Reasoning to Build Stakeholder Trust, Auditability and Regulatory Alignment. In Addition, The Framework Will Incorporate Adaptive Decision-Making Via Quantum Reinforcement Learning to Allow Continuous Optimization Under Dynamic and Uncertain Business Environments. An Energy Aware Execution Layer Will Dynamically Route Workloads Between Classical Simulators and Quantum Hardware According to Predefined Energy Budgets, Carbon Thresholds, and Performance Demands. The Overall Framework Provides a Scalable, Auditable and Ethically Aligned Blueprint for Deploying Hybrid Quantum-Classical Intelligence Within Existing Enterprise Ecosystems for Applications Such as Financial Forecasting, Retail Analytics, Dynamic Pricing, Market Risk Modeling, and Supply Chain Optimization.
Quantum programming languages and their compilers form the critical software layer between abstract quantum algorithm specifications and physical hardware execution -- yet compiler quality varies enormously across the quantum software ecosystem, with suboptimal compilation directly increasing circuit depth, gate count, and consequently error rates on NISQ hardware. This paper proposes the Quantum Compiler Design and Evaluation (QCDE) framework, a systematic methodology for quantum compiler optimisation across four compilation stages: gate synthesis (decomposing abstract gates to hardware-native gate sets), routing (mapping virtual qubits to physical qubits under connectivity constraints), scheduling (ordering gates to minimise decoherence), and cross-layer optimisation (combining all stages with error mitigation awareness). QCDE evaluates six quantum compilers (Qiskit transpiler L1-L3, TKET, BQSKit, Cirq, Quilc, and a novel QCDE-Opt compiler) on 48 benchmark circuits from the QOAS, HQCAD, and QNNDE algorithm ecosystems. QCDE-Opt achieves 18.4% lower CX gate count vs. Qiskit L3 (best existing compiler) through a novel error-aware peephole optimisation pass. BQSKit provides the best synthesis quality at 28.4% CX reduction but 12.4x compilation overhead. TKET achieves the best balance of quality and speed (8.4% CX reduction, 1.8x overhead). QCDE provides a compiler selection guide and the QCDE-Opt compiler as an open-source contribution.
The convergence of Quantum Computing (QC) and Artificial Intelligence (AI) is reshaping computational paradigms, creating the need for a new class of system software capable of managing hybrid workloads. This paper presents Q-OS, a Quantum-Aware Operating System designed to orchestrate hybrid quantum-classical AI pipelines across cloud and edge environments. Q-OS introduces three novel system components: a Quantum Scheduling Kernel that intelligently allocates portions of AI workloads (such as optimization or sampling) to quantum co-processors; a Quantum Resource Virtualization Layer that abstracts quantum devices as logical accelerators; and a Quantum-AI Compiler Interface that dynamically maps AI operations from frameworks such as TensorFlow and PyTorch into executable quantum kernels. Experimental evaluations using hybrid workloads-including large language model inference (The Pile dataset), quantum-classical generative adversarial networks (CelebA dataset), and reinforcement learning control (OpenAI Gym)-demonstrate that Q-OS achieves up to 32% reduction in end-to-end latency and 27 % improvement in energy efficiency compared to classical distributed systems. The results indicate that Q-OS establishes a scalable foundation for the next generation of intelligent computing infrastructures, bridging quantum and AI ecosystems for real-world deployment.