Quantum error mitigation (QEM) reduces the bias that hardware noise introduces into estimated observables, at the cost of additional circuit repetitions. Machine learning has been applied to it extensively since 2020, with reported reductions in that overhead. This systematic review synthesises that literature for the period January 2020 to September 2026. The review addresses three questions. First, whether the literature divides more informatively by what a model learns — a noise model, an extrapolation map, a direct noisy-to-ideal correction, or a circuit-level policy — than by its architecture. Second, what fraction of published work reports accuracy validation outside the classically simulable regime, given that supervised mitigation requires ideal reference values obtainable only where a circuit is classically tractable. Third, whether reported gains can be placed on a common scale, and how they stand against established information-theoretic lower bounds on the sampling cost of mitigation. Conducted per PRISMA 2020 with documented adaptations for a non-clinical computing literature.
Quantum error mitigation (QEM) reduces the bias that hardware noise introduces into estimated observables, at the cost of additional circuit repetitions. Machine learning has been applied to it extensively since 2020, with reported reductions in that overhead. This systematic review synthesises that literature for the period January 2020 to September 2026. The review addresses three questions. First, whether the literature divides more informatively by what a model learns — a noise model, an extrapolation map, a direct noisy-to-ideal correction, or a circuit-level policy — than by its architecture. Second, what fraction of published work reports accuracy validation outside the classically simulable regime, given that supervised mitigation requires ideal reference values obtainable only where a circuit is classically tractable. Third, whether reported gains can be placed on a common scale, and how they stand against established information-theoretic lower bounds on the sampling cost of mitigation. Conducted per PRISMA 2020 with documented adaptations for a non-clinical computing literature.
Quantum error mitigation (QEM) bridges the gap between today's noisy NISQ hardware and fault-tolerant quantum computing by reducing the effect of hardware errors on expectation value estimates without the qubit overhead of full quantum error correction. This paper proposes the Quantum Error Mitigation Design (QEMD) framework, a systematic evaluation of six QEM techniques across four circuit families on IBM Quantum Eagle and IonQ Forte: Zero-Noise Extrapolation (ZNE), Probabilistic Error Cancellation (PEC), Clifford Data Regression (CDR), Symmetry Verification (SV), Dynamical Decoupling (DD), and a novel Adaptive Ensemble Mitigation (AEM) combining ZNE and CDR with context-aware technique selection. QEMD finds: ZNE 3-point Richardson provides the best cost-performance trade-off for QAOA and VQE circuits (4.8x overhead, 28.4pp error reduction); PEC provides the highest accuracy but at 48x shot overhead -- practical only for n <= 12; DD reduces coherence-limited errors by 18.4% on IonQ Forte at zero shot overhead; AEM outperforms all individual techniques by 6.4pp at 8.4x overhead. QEMD provides a decision guide mapping circuit type, qubit count, and shot budget to optimal QEM technique selection.
Quantum computing offers exponential advantages for problems in cryptography, optimization, and quantum simulation, yet the practicality of current Noisy Intermediate-Scale Quantum (NISQ) devices is severely constrained by decoherence, gate imperfections, and measurement noise. Conventional quantum error correction (QEC) codes such as Steane and surface codes impose large qubit overheads and require high-fidelity logical operations, making them unsuitable for near-term hardware. To address this gap, this work introduces ML-QEM, an adaptive quantum error mitigation framework that employs machine learning to identify and correct dominant Pauli error patterns in real time using only 3–5 ancillary qubits. By integrating Qiskit Aer noise modeling with a lightweight TensorFlow-based classifier, ML-QEM learns device-specific noise characteristics and applies targeted recovery operations with minimal latency. Evaluations across depolarizing, amplitude damping, and thermal relaxation noise models demonstrate a 28.4% average fidelity improvement, 60–84% lower overhead than Steane and surface codes, and a classical processing delay of only 21.7 ms. ML-QEM thus provides an effective and resource-efficient pathway toward enhancing quantum computation fidelity in the NISQ era.
Noise in quantum hardware is the primary obstacle to realizing the transformative potential of quantum computing. Quantum error mitigation (QEM) offers a promising pathway to enhance computational accuracy on near-term devices, yet existing methods face a difficult trade-off between performance, resource overhead, and theoretical guarantees. In this work, we introduce neighbor-informed learning (NIL), a versatile and scalable QEM framework that unifies and strengthens existing methods such as zero-noise extrapolation (ZNE) and probabilistic error cancellation (PEC), while offering improved flexibility, accuracy, efficiency, and robustness.
NIL learns to predict the ideal output of a target quantum circuit from the noisy outputs of its structurally related ``neighbor'' circuits. A key innovation is our 2-design training method, which generates training data for our machine learning model. In contrast to conventional learning-based QEM protocols that create training circuits by replacing non-Clifford gates with uniformly random Clifford gates, our approach achieves higher accuracy and efficiency, as demonstrated by both theoretical analysis and numerical simulation. Furthermore, we prove that the required size of the training set scales only \emph{logarithmically} with the total number of neighbor circuits, enabling NIL to be applied to problems involving large-scale quantum circuits. Our work establishes a theoretically grounded and practically efficient framework for QEM, paving a viable path toward achieving quantum advantage on noisy hardware.
The pursuit of high-fidelity digital quantum simulation is fundamentally constrained by the inevitable presence of noise in current and near-term quantum processors. While quantum error correction ultimately promises fault-tolerance, its substantial qubit overhead renders it impractical for the noisy intermediate-scale quantum (NISQ) era. This research addresses the critical gap between hardware imperfections and simulation accuracy by designing systematic, resource-efficient machine learning (ML) error-mitigation protocols tailored specifically for digital quantum simulation. Unlike generic error-suppression methods, our approach exploits the unique structural properties of simulated quantum dynamics—including time-translation invariance, locality of interactions, and conserved quantities—to inform the training of lightweight neural networks and Gaussian process regressors. We develop a hybrid framework that combines randomized compiling with data-driven noise-inversion models, enabling real-time estimation and subtraction of both coherent and incoherent errors without exponential sampling overhead. Through extensive numerical benchmarks on spin-chain and Fermi-Hubbard models, we demonstrate that our ML protocols achieve up to an order-of-magnitude reduction in infidelity compared to standard probabilistic error cancellation and zero-noise extrapolation, while requiring fewer calibration circuits. Furthermore, we introduce an adaptive online learning scheme that continuously refines the mitigation model during the simulation runtime, automatically adjusting to time-dependent drift in hardware noise. Our results establish a practical pathway toward scalable, high-accuracy quantum simulations on existing devices, with implications for condensed matter physics, quantum chemistry, and the development of quantum advantage benchmarks.
Quantum error mitigation (QEM) infers noiseless expectation values from noisy variants of a target quantum circuit. Unlike quantum error correction, QEM requires no additional hardware resources and is therefore routinely employed in experiments on contemporary quantum processors. QEM strategies based on agnostic noise amplification (ANA) are intrinsically resilient to temporal noise drift during the execution of the experiment, but their sampling cost (runtime overhead) remains a major practical bottleneck. In this work, we introduce the virtual noise scaling framework and combine it with layered mitigation to further enhance performance. While virtual noise scaling consistently reduces sampling overhead, we identify a specific noise threshold for the layered mitigation approach. When the noise level is above this threshold, layered mitigation decreases the sampling overhead; conversely, when below it, the overhead increases. Notably, this threshold is circuit-independent and depends solely on the number of layers. For strong noise, the combination of virtual noise scaling and layered mitigation yields several orders of magnitude reduction in sampling overhead compared with conventional zero-noise extrapolation post-processing. As a result, mitigation tasks that once seemed unrealistic are now challenging but achievable. The proposed approach is compatible with dynamic circuits and can be seamlessly integrated with error detection and quantum error correction schemes. In addition, it is also applicable to ANA-based mitigation of mid-circuit measurements and preparation errors. Our findings extend to any constant-step amplification factors and therefore also apply to probabilistic error amplification (PEA) QEM. We validate our post-processing approach by applying it to previously reported experimental data, where we observe a substantial improvement in mitigation efficiency and accuracy.
Quantum error mitigation (QEM) is critical for harnessing the potential of near-term quantum devices. Particularly, QEM protocols can be designed based on machine learning, where the mapping between noisy computational outputs and ideal ones can be learned on a training set consisting of Clifford circuits or near-Clifford circuits that contain only a limited number of non-Clifford gates. This learned mapping is then applied to noisy target circuits to estimate the ideal computational output. In this work, we propose a learning-based error mitigation framework called Clifford Perturbation Data Regression (CPDR), which constructs training sets by Clifford circuits with small perturbations. Specifically, these circuits are parameterized quantum circuits, where the rotation angles of the gates are restricted to a narrow range, ensuring that the gates remain close to Clifford gates. This design enables the efficient simulation of the training circuits using the Sparse Pauli Dynamics method. As a result, CPDR is able to utilize training sets with a better diversity to train the model, compared with previous learning-based QEM models that construct training sets with only Clifford or near-Clifford circuits. Numerical simulations on small-scale Ising model circuits demonstrate that the performance of CPDR dramatically outperforms that of existing methods such as Zero-Noise Extrapolation and learning-based Probabilistic Error Cancellation. Furthermore, using the experimental data from IBM's 127-qubit Eagle processor, our findings suggest that CPDR demonstrates improved accuracy compared to the original mitigation results reported in [Nature 618, 500 (2023)].