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Quantum Machine Learning for Diabetes Risk Prediction Using Patient Health Data

Kelwin Kong, Senghab Cheng, Sochary Vanda, Faris Fy, Atithvicheka Keo, Ruslan Isaev

Published Sep 7, 2026• 0 citations
Publisher

Abstract

Diabetes remains one of the common chronic diseases around the world and finding a good early prediction from clinical and lifestyle data is very important for timely help. Classical machine learning models such as regression, decision trees and random forests have been used for this purpose but the complicated non‑linear connections among clinical features might need richer ways of representation. Quantum Machine Learning (QML) gives an approach using quantum feature encoding and variational circuits to find patterns that are expensive to express with classical methods. In this study we show a diabetes prediction pipeline that compares baseline models—logistic regression, decision tree and random forest—with two quantum classifiers built in Qiskit: a Quantum Support Vector Classifier (QSVC) and a Variational Quantum Classifier (VQC). Using the Pima Indians Diabetes dataset we test all models on accuracy, precision, recall and F1‑score. The results show that the classical Random Forest classifier reaches the accuracy (0.73) beating both quantum classifiers. The Quantum Support Vector Classifier (QSVC 0.66) and the Variational Quantum Classifier (VQC 0.65) are still competitive. Do not outdo the classical baselines. These results agree with reports that in the present Noisy Intermediate‑Scale Quantum (NISQ) era quantum models usually match rather than surpass well‑tuned classical approaches on standard health‑care data and that a real quantum advantage will need larger data, deeper circuits and testing, on real quantum hardware.

DOI
10.20944/preprints202609.0429.v1

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Diabetes remains one of the common chronic diseases around the world and finding a good early prediction from clinical and lifestyle data is very important for timely help. Classical machine learning models such as regression, decision trees and random forests have been used for this purpose but the complicated non‑linear connections among clinical features might need richer ways of representation. Quantum Machine Learning (QML) gives an approach using quantum feature encoding and variational circuits to find patterns that are expensive to express with classical methods. In this study we show a diabetes prediction pipeline that compares baseline models—logistic regression, decision tree and random forest—with two quantum classifiers built in Qiskit: a Quantum Support Vector Classifier (QSVC) and a Variational Quantum Classifier (VQC). Using the Pima Indians Diabetes dataset we test all models on accuracy, precision, recall and F1‑score. The results show that the classical Random Forest classifier reaches the accuracy (0.73) beating both quantum classifiers. The Quantum Support Vector Classifier (QSVC 0.66) and the Variational Quantum Classifier (VQC 0.65) are still competitive. Do not outdo the classical baselines. These results agree with reports that in the present Noisy Intermediate‑Scale Quantum (NISQ) era quantum models usually match rather than surpass well‑tuned classical approaches on standard health‑care data and that a real quantum advantage will need larger data, deeper circuits and testing, on real quantum hardware.
Quantum Machine Learning (QML) which is the integration of Quantum Mechanics (QM) and Machine Learning (ML), comes with immense computational capacity due to principles of superposition and entanglement. The PIMA diabetes dataset is used in this research as a test bed for comparing the results obtained from ML and QML approaches. The assessment shows that Support Vector Machine (SVM) has better results compared to Logistic Regression (LR) with an accuracy of 0.76. On the other hand, among QML algorithms; the Quantum Support Vector Classifier (QSVC) has a higher accuracy than the Variational Quantum Classifier (VQC) with 0.74. The findings of the given research imply that the use of QML methods may be valuable for further developments in diabetes prediction in the future.
The early detection and accurate classification of diabetes health indicators are crucial for effective disease management and prevention. This study aims to compare the performance of classical and quantum machine learning models in feature selection and classification on the Diabetes Health Indicators dataset. Initially, classical machine learning methods were employed to preprocess the data, including normalization and scaling, followed by feature selection using Lasso regression. Various traditional models, such as Logistic Regression, Decision Trees, Random Forests, Gradient Boosting, K-Nearest Neighbors, and Naive Bayes, were evaluated. Among these, the Logistic Regression model achieved the highest accuracy at 85%85 \%85%, while other models also demonstrated competitive performance with accuracies ranging from 82%82 \%82% to 85%85 \%85%. Subsequently, quantum machine learning techniques were applied using the selected features to assess their effectiveness. Quantum circuits were created using Cirq, and parameter optimization was performed through Quantum Feature Mapping and Quantum Feature Transformation. The Quantum Support Vector Machine (QSVM) model attained an accuracy of 84.33%84.33 \%84.33%, showing potential for matching the performance of traditional models. The results suggest that quantum machine learning models can offer comparable accuracy to classical methods in the classification of diabetes health indicators. This study highlights the potential benefits of integrating quantum techniques in complex data processing and recommends further exploration in future research to fully harness the capabilities of quantum machine learning.
Quantum information processing introduces novel approaches for classical data encoding to encompass the complex patterns of input data of practical computational challenges using basic principles of quantum mechanics. The classification of diabetes is an example of a problem that can be efficiently resolved by using quantum unitary operations and the variational quantum classifier (VQC). This study demonstrates the effects of the number of qubits, types of feature maps, optimizers’ class, and the number of layers in the parametrized circuit, and the number of learnable parameters in ansatz influences the effectiveness of the VQC. In total, 76 variants of VQC are analyzed for four and eight qubits’ cases and their results are compared with six classical machine learning models to predict diabetes. Three different types of feature maps (Pauli, Z, and ZZ) are implemented during analysis in addition to three different optimizers (COBYLA, SPSA and SLSQP). Experiments are performed using the PIMA Indian Diabetes Dataset (PIDD). The results conclude that VQC with six layers embedded with an error correction scaling factor of 0.01 and having ZZ feature map and COBYLA optimizer outperforms other quantum variants. The optimal proposed model attained the accuracy of 0.85 and 0.80 for eight and four qubits’ cases, respectively. In addition, the final quantum model among 76 variants was compared with six classical machine learning models. The results suggest that the proposed VQC model has outperformed four classical models including SVM, random forest (RF), decision tree (DT), and linear regression (LR).
Early diagnosis of chronic diseases is paramount to improving patient survival rates, optimizing treatment trajectories, and mitigating escalating healthcare expenditures. While the recent explosion of heterogeneous healthcare data presents robust opportunities for predictive modeling, it simultaneously introduces severe computational bottlenecks regarding data dimensionality and non-linear complexity. This paper proposes a novel, high-performance hybrid prediction framework that seamlessly fuses classical machine learning topologies with Variational Quantum Circuits (VQCs) within a Quantum Machine Learning (QML) paradigm. The proposed architecture targets the multi-classification and risk profiling of five high-prevalence chronic conditions: diabetes, cardiovascular disease, breast cancer, chronic liver disease, and chronic kidney disease This project introduces “Quantum Health,” a Quantum Machine Learning (QML)-based multi disease prediction system that integrates classical and quantum computing to enhance diagnostic performance. It employs five quantum-enhanced models: Quantum Random Forest for breast cancer, Quantum Neural Network for diabetes, Quantum k-Nearest Neighbors (QkNN) for heart disease, Quantum AdaBoost for liver disease, and Quantum Naive Bayes for kidney disease. The models are evaluated using both classical methods and PennyLane simulations, enabling direct comparison of performance. The system is deployed as a Flask-based web application featuring a user-friendly dashboard, disease-specific prediction modules, prediction history with CSV export, and an analytics dashboard comparing classical and quantum accuracies. Each module provides predictions, confidence scores, and feature importance insights. Unlike monolithic classical models, our approach incorporates a parameterized quantum layer that maps low-dimensional classical medical vectors into high-dimensional Hilbert spaces, capturing intricate, non-linear correlations that evade classical kernels. Experimental evaluations executed on simulated quantum backends demonstrate that the proposed Quantum Hybrid Model drastically outperforms conventional baselines, achieving an overall classification accuracy of 96.8% and an Area Under the Curve (AUC) of 98.4%. The findings establish that integrating quantum circuit state vectors with ensemble classical architectures provides a scalable, computationally efficient, and highly generalizable paradigm for next-generation clinical decision support systems.
This paper presents a Quantum versus classical implemented of Machine learning (ML) algorithm applied to a diabetes dataset. Diabetes is a Sixth deadliest disease in the world and approximately 10 million new cases are registered every year worldwide. Using novel Quantum computing (QC) along with Quantum Machine Learning (QML) techniques in the healthcare system to improve and accelerate the computing of existing ML models that allows the different approach to understanding the complex patterns of the disease. The proposed system tackles a binary classification problem of patients with diabetes into two different classes: diabetes patients with acute diseases and diabetes patients without acute diseases. Our study compares classical and quantum algorithms, namely Decision Tree, Random Forest, Extreme Boosting Gradient and Adaboost, Qboost, Voting Model 1, Voting Model 2, Qboost Plus, New model 1 and New Model 2 along with an ensemble method which creates a strong classifier from a committee of weak classifiers. The results we achieved using the validation metrics of the New Model 1 showed an overall precision of 69%, a recall of 69%, an F1-Score of 69%, a specificity of 69% and an accuracy of 69% on our diabetes dataset, with an increase of the computation speed by 55 times in comparison of the classical system. Our study has proved that QC improves the computational speed and its inclusion in medical applications will deliver faster results to physicians and caregivers.
Blood glucose is one of the key indicators influencing the body’s metabolic performance. Accurate prediction and proactive management of this parameter are of paramount clinical importance. In this context, the analysis and evaluation of quantum machine learning (QML) algorithms for processing medical data and enhancing the predictive accuracy of health-related models have emerged as cutting-edge research directions in recent studies. Leveraging the principles of quantum physics and computation, QML algorithms serve as a promising alternative to classical methods for predicting chronic diseases. By mapping classical data into a quantum feature space and exploiting intrinsic quantum properties such as superposition and entanglement, these algorithms significantly enhance the ability to detect complex and latent patterns within datasets. In this study, the dataset was first preprocessed using Principal Component Analysis (PCA) for dimensionality reduction and noise suppression. Subsequently, the predictive performance of two quantum machine learning models—the Quantum Support Vector Machine (QSVM) and the Variational Quantum Circuit (VQC)—was evaluated and compared with that of the classical Support Vector Machine (SVM) for blood glucose level prediction. The results indicate that the QSVM model achieves a prediction accuracy of 90%, outperforming the classical SVM, which attained an accuracy of 74.4%. Moreover, the hybrid classical–quantum VQC model demonstrated the highest predictive performance, achieving an accuracy of 94.2%, thereby establishing it as the most effective approach for blood glucose level forecasting in this experimental setting.