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Integrare prin cercetare și inovare. Științe exacte și ale naturii

Diagnose of biomolecules using raman interactions of the light

Marina Ţurcan

Published Jan 1, 2025• 0 citations
Publisher

Abstract

It is particularly important by now to apply the light in processing and development of modern diagnostic. Here with, two basic aspects of the interaction of light with the substance are discussed: the nonlinear one of light interaction with the environment, and the cooperative aspect of interaction of photons with matter (atoms or biomolecules). One should mention the use of metamaterials for tissue decontamination where the specific form of contact surface plays an important role. Another goal of the present work is the study and use of the cooperative effects of bacteria and viruses located in the evanescent field of biomaterials during Raman interaction of light in ultraviolet region. A model is proposed based upon existing experiments which takes into account the local symmetry of biomolecules. New models emerging from the non-linear interaction of the atomic (molecular) subsystem and the electromagnetic field of cavity could be elaborated. The photons statistic is proposed for the diagnosis of the new collective processes.

DOI
10.59295/spd2024n.113

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It is particularly important by now to apply the light in processing and development of modern diagnostic. Here with, two basic aspects of the interaction of light with the substance are discussed: the nonlinear one of light interaction with the environment, and the cooperative aspect of interaction of photons with matter (atoms or biomolecules). One should mention the use of metamaterials for tissue decontamination where the specific form of contact surface plays an important role. Another goal of the present work is the study and use of the cooperative effects of bacteria and viruses located in the evanescent field of biomaterials during Raman interaction of light in ultraviolet region. A model is proposed based upon existing experiments which takes into account the local symmetry of biomolecules. New models emerging from the non-linear interaction of the atomic (molecular) subsystem and the electromagnetic field of cavity could be elaborated. The photons statistic is proposed for the diagnosis of the new collective processes.
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It is particularly important by now to apply the coherent light proprieties in process control from biomolecular system. In this way, the present report has two basic aspects of the interaction of light with the substance are discussed: the nonlinear one of light interaction with the environment, and the cooperative aspect of interaction of photons with matter in specially biomolecules. Another goal of this work is the presentasions and analysys oh the hydrogen bonds between the Guanine - Cytosine (G-C) and behavior of these nucleotide during the Raman processes. Developed on the basis of experimental evidence, the model incorporates the local symmetry inherent in biomolecular structures. The photons transformation and statistic is presented for the control in the biomolecular systems.
This chapter introduces an optical framework for the generation of molecular superstructures from tertiary components through Raman-induced interactions with a bimodal cavity field. A nonlinear model is developed based on cooperative processes analogous to multiple Raman scattering and their integration with biomolecular assemblies. Particular attention is given to phase transitions leading to the formation of supramolecular structures, where induced Raman excitation enables the stabilization of multimeric states such as dimers, trimers, tetramers, and pentamers. The proposed master equation describes the synthesis and stabilization of such structures under Raman excitation. Importantly, the model can also be applied inversely, where large molecular aggregates are dissociated into smaller components via induced multiple Raman scattering. This dual mechanism provides a theoretical basis for designing highly efficient optical metamaterials with potential applications in advanced decontamination technologies. To illustrate the applicability, experimental investigations were performed using yeast fungi as a surrogate for more sensitive pathogens (viruses and bacteria). The results revealed two distinct decontamination regimes under nanosecond-pulsed ultraviolet C radiation, consistent with the predictions of the multiple Raman dimerization model. These findings highlight the potential of Raman-driven cooperative processes in both molecular synthesis and selective pathogen inactivation.
A semi-classical model (classical by the field and quantum by describing biomolecules) is proposed, which establishes the dependence of the DNA/RNA dimerization rate on ultraviolet C (UVC) radiation intensity. The two types of cooperative effects between the converted photons in these multiple steps of Raman lasing are proposed. The first type involves the cooperative process between the photons of one of the steps of Raman conversion. The second cooperative effect appears between the photons belonging to different steps of multiple conversions. This new type of generated coherent state is proposed by novel bimodal entangled sources, which take into consideration both the coherence and collective phenomena between the photons belonging to the system of the bimodal field obtained in multiple Raman emission. The application of higher-order multiple Roman bimodal coherent field quantum information is described in accordance with the definition of quantum amplitude and phase of such entangled states of light.
The cooperative excitation and absorption of light into three cavity modes (pump, Stokes and anti-Stokes), stimulated by excited radiators, is studied as bound entangled states of the photon subsystem. The three modes collective Roman emission and its connection with entangled state is defined introducing the cooperative description between photons of cavity modes. In the case, when the scattering rates in the Stokes and anti-Stokes modes coincide, the SU(2) and SU(1,1) symmetries are applied for a simple description of these cooperative processes. The possibilities to realize this effect in the free space is proposed, replacing the cavity modes with dipole active excited atoms in tow-quantum interaction with dipole-forbidden transitions of D atom. The statistical properties and detection method are proposed using the information entropy and atomic correlation functions.
The two types of cooperative effects between the converted photons in the multiple steps of Raman lasing are proposed. The first type involves the cooperative process between the photons of one of the steps of Raman conversion. The second cooperative effect appears between the photons belonging to different steps of multiple conversions. This new type of generated coherent state is proposed by novel bimodal entangled sources, which take into consideration both the coherence and collective phenomena between the photons belonging to the system of the bimodal field obtained in multiple Raman emissions. For this, the creation and annihilation operators of the new resonator quasi-particle ware introduced taking into consideration the Hilbert space of field vectors at frequency differences, ωp+1−ωp between the anti-Stokes components of multiple Raman lasing. The application of higher-order multiple Roman bimodal coherent field quantum information is described in accordance with the definition of quantum amplitude and phase of such entangled states of light. The cooperative properties of the bimodal field in the multiple scattering processes of Raman lasing in the cavity/fiber and its interaction with ensemble of atoms prepared in coherent state are proposed. We introduced the new characteristics of bi-modes field in which the multiple Raman scattering takes into consideration the interaction with coherent excitation and non-stationary quantum fluctuations of the generation rate of the introduced quasi particles. Here, we represent the rate moments through the annihilation and generation operators of the cavity quasi-parties.