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Dandao Xuebao/Journal of Ballistics

Quantum-Enhanced Heart Disease Prediction via Variational Quantum Circuits (VQC) and Machine Learning Models

Prakash Kuppuswamy

Published Jul 4, 2026• 0 citations
OpenAlex

Abstract

To forecast heart problems, an innovative hybrid technique combining quantum computing with machine learning approaches is presented. For the preprocessing stage, normalization and dimensionality reduction techniques are used on a dataset of 270 patients' records and 13 clinical variables to make them appropriate for a 4-qubit quantum computer. Some traditional machine learning algorithms, including convolutional neural networks (CNN), support vector machines (SVM), and XGBoost, are trained to establish baselines in relation to other methods. Under the guidance of the SPSA algorithm, a quantum-inspired classifier called VQC is developed using a parameterized quantum circuit that includes rotation and entanglement operations. A quantitative study of crucial performance metrics reveals that the suggested quantum technique outperforms conventional methods in tests. The VQC classifier has the highest accuracy (85.2%), precision (86.4%), and F1 score (82.6%), while matching the SVM classifier's ROC-AUC score of 88.9%. Although with lower dimensionality, this research shows how quantum-based machine learning may find complex correlations among variables. This study is intended to serve as a preliminary concept for using quantum machine learning for healthcare applications, especially for increasing the accuracy rate and lowering misdiagnosis errors.

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Cardiovascular diseases remain a leading global health challenge, driving the need for advanced, accurate diagnostic tools. While classical machine learning (ML) models like XGBoost have achieved significant success in medical diagnosis, they often face challenges related to accuracy plateaus and model explainability in complex, high-dimensional data spaces. Quantum machine learning (QML) emerges as a promising paradigm to potentially overcome these limitations by leveraging quantum computational advantages. This study aims to develop and evaluate a hybrid quantum-classical pipeline for the early detection of heart disease. We integrate robust data preprocessing—including missing value imputation, feature engineering, SMOTE for class balancing, and PCA for dimensionality reduction—with two classification approaches: a classical XGBoost model and a quantum Variational Quantum Classifier (VQC). Our results demonstrate that the XGBoost model achieves strong performance with an accuracy of 88.52% and an F1-score of 0.8852 on an imbalanced test set. While the VQC model did not surpass the classical baseline in the current noisy simulation environment, it shows theoretical promise. This work highlights the practical challenges of current QML and outlines a clear pathway for future research towards achieving a quantum advantage in clinical decision support systems.

International Conference on Networking and Advanced Systems (ICNAS)•Oct 29, 2025•0 citations
To forecast heart problems, an innovative hybrid technique combining quantum computing with machine learning approaches is presented. For the preprocessing stage, normalization and dimensionality reduction techniques are used on a dataset of 270 patients' records and 13 clinical variables to make them appropriate for a 4-qubit quantum computer. Some traditional machine learning algorithms, including convolutional neural networks (CNN), support vector machines (SVM), and XGBoost, are trained to establish baselines in relation to other methods. Under the guidance of the SPSA algorithm, a quantum-inspired classifier called VQC is developed using a parameterized quantum circuit that includes rotation and entanglement operations. A quantitative study of crucial performance metrics reveals that the suggested quantum technique outperforms conventional methods in tests. The VQC classifier has the highest accuracy (85.2%), precision (86.4%), and F1 score (82.6%), while matching the SVM classifier's ROC-AUC score of 88.9%. Although with lower dimensionality, this research shows how quantum-based machine learning may find complex correlations among variables. This study is intended to serve as a preliminary concept for using quantum machine learning for healthcare applications, especially for increasing the accuracy rate and lowering misdiagnosis errors.
Heart disease is one of the major global causes of death, requiring early and precise detection for efficient treatment.With advancements in quantum computing, Variational Quantum Circuits (VQCs) have gained recognition as a valuable technique for improving learning models in medical diagnosis.This study further explores the application of VQC-based models for heart disease prediction, leveraging quantum computing to enhance classification accuracy.A hybrid quantum-classical model has been developed, which combines classical preprocessing for feature extraction from patient datasets with a VQC-based classifier for medical predictions.The quantum circuit using variational parameters is optimized to reduce the loss function and facilitate effective learning from complex medical data.This proposed approach is tested on benchmark heart disease datasets and evaluated against classical Machine Learning (ML) models, including Support Vector Machines (SVMs), Random Forests, and Neural Networks.The experimental results show that VQC-based models achieve high accuracy and outperform classical models, notably on high-dimensional, non-linearly separable data.The quantum advantage of VQCs lies in their ability to encode and process data in a huge Hilbert space.However, challenges such as noise in near-term quantum devices and scalability issues remain key.This research underscores the efficacy of VQCbased quantum machine learning in medical diagnosis, paving the way for future studies on quantum-enhanced healthcare solutions.Further advancements in quantum hardware and hybrid learning techniques could allow quantum-assisted heart disease prediction to become an effective clinical tool.
Cardiovascular diseases remain the leading cause of mortality globally, necessitating accurate diagnostic tools for early detection and intervention. This paper presents a comprehensive comparative and hybrid analysis of quantum and classical machine learning models for heart disease prediction using the UCI Cleveland dataset. We implement classical baseline models including Logistic Regression, Random Forest, Support Vector Machine (SVM), and XGBoost, alongside quantum models: Quantum Support Vector Machine (QSVM) with statevector fidelity kernels, Variational Quantum Classifier (VQC) with data-reuploading ansätze, and Quantum Convolutional Neural Networks (QCNN) with parametric pooling. The primary contribution is the development of a hybrid quantum classical ensemble meta-classifier that fuses predictions from all classical and quantum learners using XGBoost as a meta learner. Experiments conducted in Google Colab using Qiskit 1.2+ and Penny Lane 0.36+ demonstrate that the proposed hybrid ensemble achieves superior performance with 98.33accuracy, 100perfect AUC-ROC of 1.0, substantially outperforming standalone classical models (best: 88.33(best: 80hybrid model’s superiority. These results underscore the potential of quantum feature spaces combined with classical decision boundaries in healthcare prediction systems, and demonstrate the immediate utility of hybrid quantum-classical integration in medical diagnostics on near-term quantum hardware.
Abstract Accurate early identification and treatment of cardiovascular diseases can prevent heart failure problems and reduce mortality rates. This study aims to use quantum learning to predict heart problems to increase the accuracy of traditional prediction and classification methods. Machine learning (ML) and deep learning (DL) techniques need quantum learning to quickly and accurately analyze massive volumes of complex data. With quantum computing, the suggested DL and ML algorithms can change their predictions on the basis of changes in the dataset. This approach could help with the early and accurate detection of chronic diseases. The Cleveland heart disease dataset is undergoing preliminary processing to validate missing values to increase the precision rate and prevent incorrect forecasts. This study examined the feasibility of employing and deploying a quantum ML (QML) framework via cloud computing to categorize cardiac conditions. The research was divided into four sections. First, the principal component analysis was used to preprocess the Cleveland dataset, recursive feature elimination was used to select features, and min–max normalization was used to give the dataset a high-dimensional value. Second, we compared traditional classifiers, such as support vector machine (SVM) and artificial neural network, with the quantum approach to verify the quantum approach’s efficiency. Third, we examined two unique QML classification methods: quantum neural networks (QNNs) and quantum SVM (QSVM). Fourth, bagging-QSVM was developed and deployed as an ensemble learning model. Experimental results using the QNN show an accuracy of 77%, a precision of 76%, a recall of 73%, and an F 1 score of 75%. With an accuracy of 85%, a precision of 79%, a recall of 90%, and an F 1-score of 84%, the QSVM method demonstrated a much better performance than the QNN. Particularly, the Bagging_QSVM model exhibited an outstanding performance, with a flawless score of 100% across all critical performance measures. The study shows that the bagging method for ensemble learning is a solid way of increasing the accuracy of quantum method predictions.
The healthcare systems produce a tremendous volume of medical data which may be in the form of patient records, laboratory test results and diagnostic reports. It is quite necessary to analyze such data accurately and efficiently in order to detect diseases early and plan appropriate treatment . Conventional machine learning methods have a tendency to struggling with large-dimensional and complicated medical data. To address these shortcomings, this project suggests a hybrid Quantum Machine Learning (QML) scheme of analyzing medical data and diagnosing a disease. The suggested system combines the classical data preprocessing with the quantum-enhanced data learning algorithms including Variational Quantum Circuits (VQC) and Quantum Support Vector Machines (QSVM). Medical data is first processed by cleaning, normalizing and encoding to quantum states. Complex patterns and correlations that traditional algorithms can hardly be able to learn are then learned with the quantum model. The measures used to judge the performance are accuracy, precision, recall and F1-score. The results of the experimental process show that the model based on QML yields better diagnostic accuracy than the conventional machine learning. This is where there is great potential in real time medical decision support systems, with the future prediction of disease and the personalized solution of care. The suggested framework indicates the potential and benefits of switching to quantum computing methods in healthcare analytics.
Quantum computing is fast-growing and progressive technology that provides the best results in various domains – including healthcare. In this paper, the Quantum Machine Learning (QML) algorithms, namely Quantum Support Vector Classifiers (QSVC) and Quantum Convolutional Neural Networks (QCNN), are employed for classifying cardiovascular diseases using the Cardiovascular dataset from Kaggle. In contrast with conventional models, the QML algorithms make explicit use of superposition and entanglement to compress and process highly complex and high-dimensional data. In the QSVC approach, patient data are transformed into quantum space with higher-dimensional features by quantum feature maps. This transformation aids QSVC in the process of identifying the complex patterns which are missed in traditional ML methods. In QCNN, the quantum circuits are combined with convolutional layers to capture the understandable features and improve its ability in classification. Both methods are deployed on performance metrics such as Accuracy, Precision, Recall, F1-score and AUC-ROC to show the potential of the methods. The accuracy of the produced QCNN (92%) is greater than that of QSVC (87%). The quantum models demonstrate superior performance regarding metrics and precision level as a result of their rapid convergence. A medical diagnostic revolution occurs through QML algorithms enabling classification between healthy and unhealthy cardiovascular patterns.
Cardiovascular diseases remain a leading global health challenge, driving the need for advanced, accurate diagnostic tools. While classical machine learning (ML) models like XGBoost have achieved significant success in medical diagnosis, they often face challenges related to accuracy plateaus and model explainability in complex, high-dimensional data spaces. Quantum machine learning (QML) emerges as a promising paradigm to potentially overcome these limitations by leveraging quantum computational advantages. This study aims to develop and evaluate a hybrid quantum-classical pipeline for the early detection of heart disease. We integrate robust data preprocessing—including missing value imputation, feature engineering, SMOTE for class balancing, and PCA for dimensionality reduction—with two classification approaches: a classical XGBoost model and a quantum Variational Quantum Classifier (VQC). Our results demonstrate that the XGBoost model achieves strong performance with an accuracy of 88.52% and an F1-score of 0.8852 on an imbalanced test set. While the VQC model did not surpass the classical baseline in the current noisy simulation environment, it shows theoretical promise. This work highlights the practical challenges of current QML and outlines a clear pathway for future research towards achieving a quantum advantage in clinical decision support systems.