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International Journal of Drug Delivery Technology

Design and Implement a Variational Quantum Classifier for Heart Disease Prediction

Vijayalaxmi Jeure, Veena K

Published Jul 11, 2026• 0 citations
Publisher

Abstract

Heart disease is one of the major global causes of death, requiring early and precise detection for efficient treatment.With advancements in quantum computing, Variational Quantum Circuits (VQCs) have gained recognition as a valuable technique for improving learning models in medical diagnosis.This study further explores the application of VQC-based models for heart disease prediction, leveraging quantum computing to enhance classification accuracy.A hybrid quantum-classical model has been developed, which combines classical preprocessing for feature extraction from patient datasets with a VQC-based classifier for medical predictions.The quantum circuit using variational parameters is optimized to reduce the loss function and facilitate effective learning from complex medical data.This proposed approach is tested on benchmark heart disease datasets and evaluated against classical Machine Learning (ML) models, including Support Vector Machines (SVMs), Random Forests, and Neural Networks.The experimental results show that VQC-based models achieve high accuracy and outperform classical models, notably on high-dimensional, non-linearly separable data.The quantum advantage of VQCs lies in their ability to encode and process data in a huge Hilbert space.However, challenges such as noise in near-term quantum devices and scalability issues remain key.This research underscores the efficacy of VQCbased quantum machine learning in medical diagnosis, paving the way for future studies on quantum-enhanced healthcare solutions.Further advancements in quantum hardware and hybrid learning techniques could allow quantum-assisted heart disease prediction to become an effective clinical tool.

DOI
10.25258/ijddt.16.63s.191

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Heart disease is one of the major global causes of death, requiring early and precise detection for efficient treatment.With advancements in quantum computing, Variational Quantum Circuits (VQCs) have gained recognition as a valuable technique for improving learning models in medical diagnosis.This study further explores the application of VQC-based models for heart disease prediction, leveraging quantum computing to enhance classification accuracy.A hybrid quantum-classical model has been developed, which combines classical preprocessing for feature extraction from patient datasets with a VQC-based classifier for medical predictions.The quantum circuit using variational parameters is optimized to reduce the loss function and facilitate effective learning from complex medical data.This proposed approach is tested on benchmark heart disease datasets and evaluated against classical Machine Learning (ML) models, including Support Vector Machines (SVMs), Random Forests, and Neural Networks.The experimental results show that VQC-based models achieve high accuracy and outperform classical models, notably on high-dimensional, non-linearly separable data.The quantum advantage of VQCs lies in their ability to encode and process data in a huge Hilbert space.However, challenges such as noise in near-term quantum devices and scalability issues remain key.This research underscores the efficacy of VQCbased quantum machine learning in medical diagnosis, paving the way for future studies on quantum-enhanced healthcare solutions.Further advancements in quantum hardware and hybrid learning techniques could allow quantum-assisted heart disease prediction to become an effective clinical tool.
Cardiovascular diseases remain the leading cause of mortality globally, necessitating accurate diagnostic tools for early detection and intervention. This paper presents a comprehensive comparative and hybrid analysis of quantum and classical machine learning models for heart disease prediction using the UCI Cleveland dataset. We implement classical baseline models including Logistic Regression, Random Forest, Support Vector Machine (SVM), and XGBoost, alongside quantum models: Quantum Support Vector Machine (QSVM) with statevector fidelity kernels, Variational Quantum Classifier (VQC) with data-reuploading ansätze, and Quantum Convolutional Neural Networks (QCNN) with parametric pooling. The primary contribution is the development of a hybrid quantum classical ensemble meta-classifier that fuses predictions from all classical and quantum learners using XGBoost as a meta learner. Experiments conducted in Google Colab using Qiskit 1.2+ and Penny Lane 0.36+ demonstrate that the proposed hybrid ensemble achieves superior performance with 98.33accuracy, 100perfect AUC-ROC of 1.0, substantially outperforming standalone classical models (best: 88.33(best: 80hybrid model’s superiority. These results underscore the potential of quantum feature spaces combined with classical decision boundaries in healthcare prediction systems, and demonstrate the immediate utility of hybrid quantum-classical integration in medical diagnostics on near-term quantum hardware.
Cardiovascular diseases remain a leading global health challenge, driving the need for advanced, accurate diagnostic tools. While classical machine learning (ML) models like XGBoost have achieved significant success in medical diagnosis, they often face challenges related to accuracy plateaus and model explainability in complex, high-dimensional data spaces. Quantum machine learning (QML) emerges as a promising paradigm to potentially overcome these limitations by leveraging quantum computational advantages. This study aims to develop and evaluate a hybrid quantum-classical pipeline for the early detection of heart disease. We integrate robust data preprocessing—including missing value imputation, feature engineering, SMOTE for class balancing, and PCA for dimensionality reduction—with two classification approaches: a classical XGBoost model and a quantum Variational Quantum Classifier (VQC). Our results demonstrate that the XGBoost model achieves strong performance with an accuracy of 88.52% and an F1-score of 0.8852 on an imbalanced test set. While the VQC model did not surpass the classical baseline in the current noisy simulation environment, it shows theoretical promise. This work highlights the practical challenges of current QML and outlines a clear pathway for future research towards achieving a quantum advantage in clinical decision support systems.
Cardiovascular disease is one of the most common reasons of increases the global death rate, suggesting initial detection and timely treatment crucial. While traditional machine learning models have been effective in predicting heart disease, Quantum Computing (QC) introduces new possibilities for improving accuracy and processing speed. In this regard the application of Quantum Machine Learning (QML) approaches-categorically, Quantum Neural Networks (QNN) and Quantum Support Vector Classification (QSVC)-to predict heart disease using key health indicators such as present-age, levels of cholesterol, Blood Pressure (BP), and lifestyle choices. QNN is utilized to recognize complex patterns in patient data, leveraging deep learning to understand intricate connections between various risk factors. Meanwhile, QSVC takes advantage of QC ability to compute large amounts of information at once, making classification faster and more precise. Both models are trained and tested on a heart disease dataset and compared with traditional machine learning methods to assess their accuracy, efficiency, and scalability. The results show that while quantum and classical models achieve similar accuracy, quantum computing significantly reduces processing time, making it highly efficient for analyzing large datasets. This study highlights the strength of QC in transforming medical diagnostics, offering faster and more reliable predictive models for early heart disease detection. By integrating quantum algorithms into healthcare, this research contributes to the advancement of AI-driven medical solutions, resulting in more efficient and individual patient care.
To forecast heart problems, an innovative hybrid technique combining quantum computing with machine learning approaches is presented. For the preprocessing stage, normalization and dimensionality reduction techniques are used on a dataset of 270 patients' records and 13 clinical variables to make them appropriate for a 4-qubit quantum computer. Some traditional machine learning algorithms, including convolutional neural networks (CNN), support vector machines (SVM), and XGBoost, are trained to establish baselines in relation to other methods. Under the guidance of the SPSA algorithm, a quantum-inspired classifier called VQC is developed using a parameterized quantum circuit that includes rotation and entanglement operations. A quantitative study of crucial performance metrics reveals that the suggested quantum technique outperforms conventional methods in tests. The VQC classifier has the highest accuracy (85.2%), precision (86.4%), and F1 score (82.6%), while matching the SVM classifier's ROC-AUC score of 88.9%. Although with lower dimensionality, this research shows how quantum-based machine learning may find complex correlations among variables. This study is intended to serve as a preliminary concept for using quantum machine learning for healthcare applications, especially for increasing the accuracy rate and lowering misdiagnosis errors.
Cardiovascular disease remains one of the leading causes of death worldwide, making early and accurate risk prediction essential. Conventional machine learning models often struggle to handle complex medical data, resulting in limited accuracy and reduced interpretability. To address these challenges, this study presents a hybrid prediction framework that combines Quantum Machine Learning (QML) with ensemble learning techniques. Classical models such as Support Vector Classifier (SVC) and Artificial Neural Network (ANN) are used as baseline approaches. In addition, quantum models including QSVC, Variational Quantum Classifier (VQC), and Quantum Neural Network (QNN) are employed to capture complex non-linear patterns present in clinical data. To further enhance performance, a Bagging-QSVC ensemble model is proposed, improving robustness and overall classification accuracy. Interpretability is incorporated using SHAP, allowing the model’s predictions to be more transparent and easier to understand in a clinical context. Experimental results indicate that the proposed quantum ensemble achieves an accuracy of around 90%, outperforming both classical models and individual quantum models. Furthermore, a real-time user interface is developed, enabling clinicians to input patient data and receive immediate risk predictions. Overall, the system provides a reliable and interpretable solution suitable for practical clinical decision support.
This paper explores the use of quantum-based machine learning algorithms for predicting heart disease. Traditional methods face challenges in processing complex healthcare data efficiently. To address this, quantum computing techniques, including dimensionality reduction and feature optimization, are applied. Quantum machine learning models, such as Variational Quantum Classifier (VQC), Quantum Support Vector Classification (QSVC) and Quantum Neural Networks (QNN), leverage these enriched datasets. This convergence of quantum computing and healthcare has the potential to transform medical care, cut costs, and save lives, presenting a significant advancement in predictive medicine.