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IEEE International Conference on AI in Cybersecurity (ICAIC)

SARS-CoV-2 Classification Using Classical vs. Quantum Machine Learning: A Performance Comparison of SVM, QSVM, and Pegasos

Sthefanie Jofer Gomes Passo, Muntakim Haque, Vishal H. Kothavade, John Jeffery Prevost

Published Feb 18, 2026• 3 citations
Publisher

Abstract

Quantum Machine Learning (QML) integrates principles of quantum computation with statistical learning to address classification tasks. This paper conducts a comparative study of three paradigms—classical Support Vector Classification (SVC), Quantum Support Vector Classification (QSVC) using quantum kernels, and QSVC enhanced via the Pegasos stochastic algorithm. We benchmark classification accuracy on a SARS-CoV-2 dataset, analyzing model robustness and resource requirements. Our results indicate that while classical SVC maintains superior scalability and stability for large datasets, QSVC variants show competitive accuracy across simulator backends (Central Processing Units or CPUs and Graphical Processor Units or GPUs) and may achieve quantum advantage as hardware matures. Implications for hybrid workflows and future research directions are discussed.

DOI
10.1109/icaic67076.2026.11395812

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Quantum Machine Learning (QML) integrates principles of quantum computation with statistical learning to address classification tasks. This paper conducts a comparative study of three paradigms—classical Support Vector Classification (SVC), Quantum Support Vector Classification (QSVC) using quantum kernels, and QSVC enhanced via the Pegasos stochastic algorithm. We benchmark classification accuracy on a SARS-CoV-2 dataset, analyzing model robustness and resource requirements. Our results indicate that while classical SVC maintains superior scalability and stability for large datasets, QSVC variants show competitive accuracy across simulator backends (Central Processing Units or CPUs and Graphical Processor Units or GPUs) and may achieve quantum advantage as hardware matures. Implications for hybrid workflows and future research directions are discussed.
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A potential path forward is Quantum Machine Learning (QML), which aims to leverage quantum computing in conjunction with classical machine learning to enhance computing efficiency and the expressiveness of models. In this paper, two different quantum classifiers - Variational Quantum Classifier (VQC) and Quantum Kernel Support Vector Machine (QSVM) - are compared with three classical classifiers as baseline classifiers - Logistic Regression, Support Vector Machine (SVM), and a Multi-Layer Perceptron (MLP) - on the Breast Cancer Wisconsin dataset. The quantum circuits were created in the PennyLane framework and simulated on a classical backend. However, in terms of accuracy, classical Logistic Regression performed better with an accuracy of 97.8%, classical SVM and QSVM with an accuracy of 95.6% each, although the Quantum VQC achieved a lower accuracy of 88.9% and had a recall of 100% for the benign class, though it correctly identified only 12 of the 17 malignant cases (a malignant-class recall of approximately 70.6%). The drawback of quantum models is the higher training time; however, since the quantum circuit needs to be classically simulated, the quantum SVM took 23.29 seconds compared to less than 0.01 seconds for the classical linear models. These results indicate that for small structured datasets, classifiers based on quantum computing have not yet surpassed well-tuned classical counterparts. In some respects (e.g., benign-class recall), they perform competitively, though not on malignant-class recall, where the VQC in particular performed worse than the classical baselines, which is worth further investigation on real quantum computers.
Quantum machine learning has emerged as a promising frontier, leveraging the principles of quantum computing to enhance classical algorithms. This paper proposes an optimized Quantum Support Vector Classifier (QSVC) for the classification of the MNIST dataset (a benchmark in handwritten digit recognition). We employ a Chebyshev Parameterized Quantum Circuit (PQC) with an increased number of qubits and layers, and utilize an existing projected quantum kernel method to effectively capture the complex patterns in the data. To enhance model robustness, data augmentation techniques are applied, and dimensionality reduction is performed using Principal Component Analysis (PCA). The proposed QSVC demonstrates competitive accuracy on both the training and testing datasets, highlighting the potential of quantum kernel methods in practical machine learning applications. A comparative analysis with classical Support Vector Machines (SVM) demonstrates the feasibility of quantum methods for high-dimensional classification tasks. Additionally, we investigate the impact of varying the number of qubits in the quantum circuit, providing in-depth insights into the scalability and performance trade-offs of quantum kernel methods.