In the realm of intelligent healthcare, there is a growing ambition to reshape medical services through the integration of artificial intelligence (AI). However, conventional machine learning faces inherent challenges such as privacy issues, delayed updates, and protracted training times, particularly due to the hesitance of medical institutions to directly share sensitive data, with possible noises. In response to these concerns, a Quantum-Assisted Federated Intelligent Diagnosis Algorithm ( $$\beta $$ -QuAFIDA) is proposed, applied into real medical data. Leveraging the capabilities of the 5G mobile network, this approach works the connection between Internet of Medical Things (IoMT) devices through the 5G, synchronizing training and updating the server model without disrupting their real-world applications. In our quest to safeguard patient data and enhance training efficiency, our study employs an innovative heuristic approach marked by a nested loop structure. Specifically, the inner loop is dedicated to training the beta-variational quantum eigensolver ( $$\beta $$ -VQE) to approximate the expectation values of the proposed algorithm; the outer loop trains the $$\beta $$ -QuAFIDA to reduce the relative entropy towards the target. This approach involves a balance between privacy considerations and the urgency of training. Results demonstrate that representations with low-rank attained through $$\beta $$ -QuAFIDA offer an effective approach for acquiring low-rank states. This research signifies a step forward in the synergy between AI and 5G technologies, presenting a novel avenue for the advancement of intelligent healthcare.
In the realm of intelligent healthcare, there is a growing ambition to reshape medical services through the integration of artificial intelligence (AI). However, conventional machine learning faces inherent challenges such as privacy issues, delayed updates, and protracted training times, particularly due to the hesitance of medical institutions to directly share sensitive data, with possible noises. In response to these concerns, a Quantum-Assisted Federated Intelligent Diagnosis Algorithm ( β -QuAFIDA) is proposed, applied into real medical data. Leveraging the capabilities of the 5G mobile network, this approach works the connection between Internet of Medical Things (IoMT) devices through the 5G, synchronizing training and updating the server model without disrupting their real-world applications. In our quest to safeguard patient data and enhance training efficiency, our study employs an innovative heuristic approach marked by a nested loop structure. Specifically, the inner loop is dedicated to training the beta-variational quantum eigensolver ( β -VQE) to approximate the expectation values of the proposed algorithm; the outer loop trains the β -QuAFIDA to reduce the relative entropy towards the target. This approach involves a balance between privacy considerations and the urgency of training. Results demonstrate that representations with low-rank attained through β -QuAFIDA offer an effective approach for acquiring low-rank states. This research signifies a step forward in the synergy between AI and 5G technologies, presenting a novel avenue for the advancement of intelligent healthcare.
Smart healthcare aims to revolutionize medical services by integrating artificial intelligence (AI). The limitations of classical machine learning include privacy concerns that prevent direct data sharing among medical institutions, untimely updates, and long training times. To address these issues, this study proposes a digital twin-assisted quantum federated learning algorithm (DTQFL). By leveraging the 5G mobile network, digital twins (DT) of patients can be created instantly using data from various Internet of Medical Things (IoMT) devices and simultaneously reduce communication time in federated learning (FL) at the same time. DTQFL generates DT for patients with specific diseases, allowing for synchronous training and updating of the variational quantum neural network (VQNN) without disrupting the VQNN in the real world. This study utilized DTQFL to train its own personalized VQNN for each hospital, considering privacy security and training speed. Simultaneously, the personalized VQNN of each hospital was obtained through further local iterations of the final global parameters. The results indicate that DTQFL can train a good VQNN without collecting local data while achieving accuracy comparable to that of data-centralized algorithms. In addition, after personalized training, the VQNN can achieve higher accuracy than that without personalized training.
Federated learning (FL) is a privacy-preserving alternative to centralized machine learning, where model training is performed on local devices and only global model updates are shared, effectively addressing challenges, such as data silos and privacy protection. Recently, quantum FL (QFL), an emerging FL branch, has garnered significant attention in many industry applications. However, existing QFL algorithms predominantly employ average weighting for global model training, which shows poor performance on heterogeneous healthcare data. To address this challenge, this study proposes a dynamic aggregation QFL algorithm (DAQFL) for intelligent diagnosis. Specifically, it utilizes quantum neural networks (QNNs) as local training models and designs corresponding variational quantum circuits (VQC). To mitigate performance degradation caused by the heterogeneity of medical industrial data, a dynamic aggregation method based on accuracy is proposed to enhance global model performance effectively. Extensive experiments with three distribution settings, including independent and identically distributed (IID), non-independent and identically distributed (Non-IID), and long-tail datasets, show that DAQFL outperforms baseline algorithms in accuracy and training speed. It also performs well in privacy protection and robustness of anti-noise, improving its suitability for real-world medical applications.
Energy-efficient healthcare systems are becoming increasingly critical for Industry 5.0 as the Internet of Medical Things (IoMT) expands, particularly with the integration of 5G technology. 5G-enabled IoMT systems allow real-time data collection, high-speed communication, and enhanced connectivity between medical devices and healthcare providers. However, these systems face energy consumption and data security challenges, especially with the growing number of connected devices operating in Industry 5.0 environments with limited power resources. Quantum computing integrated with machine learning (ML) algorithms, forming quantum machine learning (QML), offers exponential improvements in computational speed and efficiency through principles such as superposition and entanglement. In this paper, we propose and evaluate three QML algorithms, which are UU, variational UU, and UU-quantum neural networks (QNN) for classifying data from four different datasets: 5G-South Asia, Lumos5G 1.0, WUSTL EHMS 2020, and PS-IoT. Our comparative analysis, using various evaluation metrics, reveals that the UU-QNN method not only outperforms the other algorithms in the 5G-South Asia and WUSTL EHMS 2020 datasets, achieving 100% accuracy, but also aligns with the human-centric goals of Industry 5.0 by allowing more efficient and secure healthcare data processing. Furthermore, the robustness of the proposed quantum algorithms is verified against several noisy channels by analyzing accuracy variations in response to each noise model parameter, which contributes to the resilience aspect of Industry 5.0. These results offer promising quantum solutions for 5G-enabled IoMT healthcare systems by optimizing data classification and reducing power consumption while maintaining high levels of security even in noisy environments.
Abstract Healthcare organizations have a high volume of sensitive data and traditional technologies have limited storage capacity and computational resources. The prospect of sharing healthcare data for machine learning is more arduous due to firm regulations related to patient privacy. The balanced protection of confidentiality, integrity, and availability of healthcare data, has become a major concern beyond classical data security considerations. In recent years, federated learning offers a solution to accelerate distributed machine learning addressing concerns related to data privacy and governance. Currently, the blend of quantum computing and machine learning has experienced significant attention from academic institutions and research communities. Quantum computers have shown the potential to bring huge benefits to the healthcare sector through efficient distributed training across several quantum nodes. The ultimate objective of this work is to develop a quantum federated learning framework (QFL) to tackle the optimization, security, and privacy challenges in the healthcare and clinical industries for medical imaging tasks. In this work, we proposed federated quantum convolutional neural networks (QCNNs) with distributed training across edge devices. To demonstrate the feasibility of the proposed QFL framework, we performed extensive experiments on medical datasets (Pneumonia MNIST, and CT-kidney disease analysis), which are non-independently and non-identically partitioned among the healthcare institutions/clients. The quantum federated global model maintained a high classification testing accuracy and generalizability and outperformed the locally train clients regardless of how unbalanced the medical data is distributed among the clients. The global model achieved the best performance as compared to local clients in terms of the area under curve of the receiver operating characteristic curve (AUCROC) (0.953) and an average of (0.98) on all classes for predicting outcomes on pneumonia and CT-kidney datasets, respectively. Moreover, the client selection mechanism is proposed to reduce the computation overhead at each communication round, which effectively improves the convergence rate. The proposed quantum federated learning framework is validated and assessed via large-scale simulations. Based on our results from numerical simulations, the deployment of distributed and secure quantum machine learning algorithms for enabling scalable and privacy-preserving intelligent healthcare applications would be extremely valuable.
The emergence of 5G networks has revolutionized healthcare delivery by enabling communication with ultra-low latency, massive connectivity, and quick access to IoT devices' medical data. The digitalization of healthcare has, however, introduced privacy, data security, and scalability as major challenges, and the issues have been worsened by the rapid digitalization of the healthcare industry. The current review paper is a comprehensive evaluation of the role of Quantum Machine Learning (QML) as a paradigm for data handling with privacy preserved in the healthcare ecosystems supported by 5G. It collects advancements in quantum cryptography, Quantum Key Distribution (QKD), federated learning, and blockchain technology to explore how the combining of such technologies will enhance the confidentiality, interoperability, and real-time decision-making of the data. The review arranges and compares the state-of-theart research of 2019-2025, in which the trends, architectures, and security protocols that link classical and quantum methods in healthcare analytics become visible. It also addresses the main hurdles like quantum hardware limitations, interoperability gaps, and the tuning of federated models, and it indicates potential future research paths for the development of healthcare infrastructure that is scalable, reliable, and quantum-resistant. In conclusion, this paper gives a thorough understanding of how quantum intelligence can alter the data security and privacy landscape in 5G-enabled smart healthcare systems.
This chapter develops an integrated framework for quantum-enhanced federated digital twins in Internet of Medical Things (IoMT)-based smart healthcare systems. It explains how continuous sensing, edge intelligence, federated learning, digital twin modeling, and near-term hybrid quantum-classical machine learning can be combined to support privacy-preserving predictive and personalized medicine. The chapter argues that the value of quantum-enhanced healthcare should not be framed as immediate quantum superiority, but as a disciplined pathway for testing quantum kernels, variational circuits, quantum-inspired optimization, and hybrid classifiers against strong classical baselines. It presents a layered architecture, clinical use cases, security safeguards, implementation challenges, and research directions. The chapter provides a clinically grounded and ethically cautious roadmap for researchers, healthcare AI developers, hospital leaders, and policymakers seeking trustworthy intelligent healthcare without centralizing sensitive patient data.