In this paper, macroscopic quantum tunneling (MQT) effect of
Z2 topological order in the Wen-Plaquette model is studied. This kind of MQT is characterized by quantum tunneling processes of different virtual quasiparticles moving around a torus. By a high-order degenerate perturbation approach, the effective pseudospin models of the degenerate ground states are obtained. From these models, we get the energy splitting of the ground states, which are consistent with those obtained from exact diagonalization method.