Error mitigation is essential for unlocking the full potential of quantum algorithms and accelerating the timeline toward quantum advantage. As quantum hardware progresses to push the boundaries of classical simulation, efficient and robust error mitigation methods are becoming increasingly important for producing accurate and reliable outputs. However, existing error-mitigation approaches face a fundamental tradeoff between practical performance and reliability: heuristic methods such as zero-noise extrapolation (ZNE) enjoy faster runtime but lack accuracy guarantees, while rigorous techniques such as probabilistic error cancellation (PEC) provide unbiased estimates at prohibitive computational cost. We introduce a characterization-based, rigorously-grounded quantum error mitigation and error suppression framework (QESEM) that resolves this tradeoff by leveraging the accuracy guarantees of quasi-probabilistic mitigation with dramatically reduced overhead. We explain the innovative methods underlying QESEM and demonstrate its capabilities in the largest utility-scale error mitigation experiment based on an unbiased method. This experiment simulates the kicked transverse field Ising model with far-from-Clifford parameters on an IBM Heron device. We further validate QESEM's versatility across arbitrary quantum circuits and devices through high-accuracy error-mitigated molecular VQE circuits executed on IBM Heron and IonQ trapped-ion devices. Compared with multiple variants of the widely used zero-noise extrapolation method, QESEM consistently achieves higher accuracy while avoiding the prohibitive runtime overhead associated with PEC. These results mark a significant step forward in accuracy and reliability for running quantum circuits on current devices across diverse applications. Finally, we provide projections of QESEM's performance on near-term devices toward quantum advantage.
Error mitigation is essential for unlocking the full potential of quantum algorithms and accelerating the timeline toward quantum advantage. As quantum hardware progresses to push the boundaries of classical simulation, efficient and robust error mitigation methods are becoming increasingly important for producing accurate and reliable outputs. However, existing error-mitigation approaches face a fundamental tradeoff between practical performance and reliability: heuristic methods such as zero-noise extrapolation (ZNE) enjoy faster runtime but lack accuracy guarantees, while rigorous techniques such as probabilistic error cancellation (PEC) provide unbiased estimates at prohibitive computational cost. We introduce a characterization-based, rigorously-grounded quantum error mitigation and error suppression framework (QESEM) that resolves this tradeoff by leveraging the accuracy guarantees of quasi-probabilistic mitigation with dramatically reduced overhead. We explain the innovative methods underlying QESEM and demonstrate its capabilities in the largest utility-scale error mitigation experiment based on an unbiased method. This experiment simulates the kicked transverse field Ising model with far-from-Clifford parameters on an IBM Heron device. We further validate QESEM's versatility across arbitrary quantum circuits and devices through high-accuracy error-mitigated molecular VQE circuits executed on IBM Heron and IonQ trapped-ion devices. Compared with multiple variants of the widely used zero-noise extrapolation method, QESEM consistently achieves higher accuracy while avoiding the prohibitive runtime overhead associated with PEC. These results mark a significant step forward in accuracy and reliability for running quantum circuits on current devices across diverse applications. Finally, we provide projections of QESEM's performance on near-term devices toward quantum advantage.
Quantum error mitigation (QEM) bridges the gap between today's noisy NISQ hardware and fault-tolerant quantum computing by reducing the effect of hardware errors on expectation value estimates without the qubit overhead of full quantum error correction. This paper proposes the Quantum Error Mitigation Design (QEMD) framework, a systematic evaluation of six QEM techniques across four circuit families on IBM Quantum Eagle and IonQ Forte: Zero-Noise Extrapolation (ZNE), Probabilistic Error Cancellation (PEC), Clifford Data Regression (CDR), Symmetry Verification (SV), Dynamical Decoupling (DD), and a novel Adaptive Ensemble Mitigation (AEM) combining ZNE and CDR with context-aware technique selection. QEMD finds: ZNE 3-point Richardson provides the best cost-performance trade-off for QAOA and VQE circuits (4.8x overhead, 28.4pp error reduction); PEC provides the highest accuracy but at 48x shot overhead -- practical only for n <= 12; DD reduces coherence-limited errors by 18.4% on IonQ Forte at zero shot overhead; AEM outperforms all individual techniques by 6.4pp at 8.4x overhead. QEMD provides a decision guide mapping circuit type, qubit count, and shot budget to optimal QEM technique selection.
Noise in quantum hardware is the primary obstacle to realizing the transformative potential of quantum computing. Quantum error mitigation (QEM) offers a promising pathway to enhance computational accuracy on near-term devices, yet existing methods face a difficult trade-off between performance, resource overhead, and theoretical guarantees. In this work, we introduce neighbor-informed learning (NIL), a versatile and scalable QEM framework that unifies and strengthens existing methods such as zero-noise extrapolation (ZNE) and probabilistic error cancellation (PEC), while offering improved flexibility, accuracy, efficiency, and robustness.
NIL learns to predict the ideal output of a target quantum circuit from the noisy outputs of its structurally related ``neighbor'' circuits. A key innovation is our 2-design training method, which generates training data for our machine learning model. In contrast to conventional learning-based QEM protocols that create training circuits by replacing non-Clifford gates with uniformly random Clifford gates, our approach achieves higher accuracy and efficiency, as demonstrated by both theoretical analysis and numerical simulation. Furthermore, we prove that the required size of the training set scales only \emph{logarithmically} with the total number of neighbor circuits, enabling NIL to be applied to problems involving large-scale quantum circuits. Our work establishes a theoretically grounded and practically efficient framework for QEM, paving a viable path toward achieving quantum advantage on noisy hardware.
Abstract The practical application of Noisy Intermediate-Scale Quantum (NISQ) hardware is fundamentally limited by gate-level noise, which corrupts computational results. This research addresses this challenge through the development and validation of a modular software framework for Quantum Error Mitigation (QEM). We implement and compare two leading QEM strategies: Zero-Noise Extrapolation (ZNE) and Probabilistic Error Cancellation (PEC). The framework is built using the Qiskit library and is validated using a realistic, hardware-calibrated noisy simulator that mimics the error characteristics of a real IBM Quantum device. Our methodology focuses on a robust implementation of ZNE via unitary folding and a proof-of-concept demonstration of the PEC algorithm. The framework's effectiveness is demonstrated on a simulated noisy backend where, for a 3-qubit Greenberger-Horne-Zeilinger (GHZ) state, the baseline state fidelity was increased from 93.5% to 97.3% via ZNE, corresponding to a 59% reduction in the state's infidelity. This work provides a practical demonstration of how software-based error mitigation can enhance the reliability of quantum computations on current noisy hardware.
Quantum error mitigation (QEM) is typically viewed as a suite of practical techniques for today's noisy intermediate-scale quantum devices, with limited relevance once fault-tolerant quantum computers become available. In this work, we challenge this conventional wisdom by showing that QEM can continue to provide substantial benefits in the era of quantum error correction (QEC), and in an even more efficient manner than it does on current devices. We introduce a framework for logical-level QEM that leverages soft information naturally produced by QEC decoders, requiring no additional data, hardware modifications, or runtime overhead beyond what QEC protocols already provide. Within this framework, we develop and analyze three logical-level QEM techniques: post-selection and runtime abort policies, probabilistic error cancellation, and zero-noise extrapolation. Our techniques reduce logical error rates by more than 100x while discarding fewer than 0.1% of shots; they also provide in situ characterization of logical channels for QEM protocols. As a proof of principle, we benchmark our approach using a surface-code architecture and two state-of-the-art decoders based on tensor-network contraction and minimum-weight perfect matching. We evaluate logical-level QEM on random Clifford circuits and molecular simulation algorithms and find that, compared to previous approaches relying on QEC only or QEC combined with QEM, we can achieve up to 87.4% spacetime overhead savings. Our results demonstrate that logical-level QEM with QEC decoder soft information can reliably improve logical performance, underscoring the efficiency and usefulness of QEM techniques for fault-tolerant quantum computers.
Abstract Quantum computing has recently emerged as a novel paradigm for solving problems otherwise intractable on classical computers, yet the practical progress of quantum computers is severely impacted by noise, decoherence, and imperfect gate operations in Noisy Intermediate-Scale Quantum (NISQ) devices. Specific to IBM Quantum hardware, imperfections due to readout error, gate errors, and device drift, which depends on time, resolves limits for the accuracy of outputs from our algorithms. The mitigation strategies currently used, for example, Measurement Error Mitigation (MEM), Zero Noise Extrapolation (ZNE), and Clifford Data Regression (CDR), offer improvement over raw, unmitigated outputs, but they are static and not dynamic; the reduction of noise in within an NISQ device is temporal and can vary in patterns that are non-zero. In addition to this, using the conventional methods provides inconsistent and suboptimal results.This study will provide enhanced reliability with respect to performing quantum computation on IBM Quantum hardware with a unique mitigation framework that is adaptive and computationally efficient for a high-fidelity output. The problem taken on here is the failure of existing error mitigation strategies to provide adaptive noise compensation, as they assume a statically-distributed error, despite the performance-related characteristics already being documented in regards to calibration drift and variation over time.To achieve this, we propose a Hybrid Adaptive Error Mitigation (HAEM) approach that includes baseline measurement error mitigation and an additional correction layer that utilizes realtime calibration information, along with lightweight machine learning models. The approach can be broken down into three steps: (i) perform standard measurement error mitigation to reduce classical readout noise, (ii) execute compact calibration circuits, such as Bell states, GHZ states and Clifford benchmarks to capture then current error profile of the device, and (iii) use a lightweight machine learning model (having been trained on historical and newest calibration data) to dynamically change the mitigation weights applied for the target quantum algorithm. All implementation is done using Qiskit Runtime to ensure low-latency execution, and we completed experiments on both Qiskit Aer noisy simulators and IBM Quantum devices.Initial results suggest HAEM improved the outputs of quantum algorithms' fidelity compared to the unmitigated runs and the baseline measurement error mitigation (MEM) runs. On the noisy simulators, HAEM increased fidelity from a raw performance of 0.65 to 0.87, nearly a 34% improvement. In fairer hardware-like scenarios, fidelity-on-average was persistently 12% better than MEM, with nearly equal time duration for the additional adaptive measurements. The adaptive aspect of HAEM consistently supported subsequent calibration cycles of the device and was effective to continue providing fidelity improvements despite the static mitigation performance degrading.To sum up, the proposed HAEM framework is a modern and viable alternative for error mitigation which brings together the benefits of baseline approaches with corrections that are driven by fixed-function error-corrective, adaptive learning. As both learning-based and standard baseline approaches can only achieve fixed levels of performance, HAEM, through its use of noise mitigation both at execution time and through correlating it with standard data, provides a route towards reliable quantum computations on current IBM hardware. HAEM also presents a contribution to the NISQ error-resilient landscape, and however it is intended that it will continue to improve future applications of hybrid workflows of quantum and classical computation where error mitigation and resilience is important.
Quantum error mitigation (QEM) is essential for extracting chemically accurate results from near-term quantum hardware. Many widely used QEM methods rely on uncontrolled heuristics whose bias depends on the specific circuit and noise realization. In this work, we employ QESEM---a characterization-based, unbiased quasi-probabilistic mitigation method---on IBM's Aachen quantum processor to compute the ground-state potential energy surface (PES) of the symmetrically-stretched water molecule. We consider a classically-optimized, single-layer perfect-pairing tiled unitary product state ansatz. We map this ansatz to an 8-qubit register corresponding to a (4,4) active space and the STO-3G basis set. Compared to the statevector reference, we find that raw QPU results typically overestimate the ground-state energy by around 500~mHa across the scanned geometries. On the other hand, QESEM-mitigated results fall approximately within 100~mHa, 30~mHa, or ``chemical accuracy'' ($\sim$1.5~mHa), depending on the target precision. We benchmark QESEM at both loose (0.1~Ha) and tight (0.01~Ha) precision targets, evaluating both individual and merged batches of runs. As the precision target is tightened, the accuracy improves systematically, matching or exceeding results reported in the literature. We further quantify the sampling cost of these results, reporting the number of shots required at each precision level. Our results show how, with the current levels of hardware error, reaching the highest accuracies demands substantial QPU time. The results demonstrate that the characterization-based, unbiased error mitigation provided by QESEM allows to measure quantitatively meaningful potential energy surfaces on current quantum hardware. Concurrently, they highlight the sampling overhead associated with QEM, which remains a central bottleneck en route to larger chemical problems and higher precision.