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Stefano Martina

Stefano Martina

Joined April 2, 2026

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Quantum Vehicle Routing Problem: a smart initialization strategy for ill-conditioned optimization landscapes

Emanuele Casciaro, Mario De Simone, Stefano Martina +3 more

With the expansion of complex transport infrastructure, new paths for linking different destinations have emerged, allowing the definition of multiple routes. The introduction of new roads may also lead to disruptions in traffic flow. This problem can be generalized into a special case of VRP, which aims to find the optimal route for a fleet of vehicles within a network of destinations. Finding solutions to this problem requires an exponential number of operations, hindering the ability of exact solvers to deal with large instances, which must therefore be tackled using heuristics, often leading to suboptimal results. Quantum-based algorithms may allow us to find exact solutions in polynomial time with high probability, offering a potential future alternative to classical solvers and in this work, we focus on the QAOA. Our novel contributions are a parameter-initialization strategy that improves the convergence probability and the integration of the subtour constraints directly into the optimization without using additional qubits by employing an approximation of exponential equality constraints. We believe that our results pave the way for effectively solving instances of VRP using quantum-based solutions, leveraging the space-efficient problem encoding and our initialization strategy, which limits the effect of barren-plateau under random parameter initialization.

quant-pharXiv:2610.41120•Nov 2, 2026•0 citations

Quantum Diffusion Models for Medical Image Analysis

Francesco Aldo Venturelli, Stefano Martina, Marco Parigi +3 more

Quantum Machine Learning is a novel field of research aimed at devising machine learning approaches exploiting principles of quantum mechanics, such as superposition, entanglement and interference. In this context, we present a scalable hybrid Quantum Diffusion Model, and evaluate its use for medical image analysis. Specifically, our method is based on a Discrete-Time Quantum Walk algorithm, executed on a real quantum device, to model the forward dynamics of the diffusion model. For the backward step of the diffusion model, we devise and evaluate a classical learning model, which is used to reversely denoise the data. In contrast with other existing attempts at applying quantum machine learning for image analysis tasks, severely limited by the size of existing quantum devices, our method allows to process real-world large size medical data. In particular, we present results on grayscale and RGB images, as well as 3D volumes of moderate sizes. We benchmark our results by reproducing an alternative classical counterpart model, based on diffusion models on discrete state spaces. By doing so, we compare the generation capabilities of both models in terms of three distinct state-of-the-art metrics in the field of image generation, showing the competitive, promising results of our approach.

eess.IVCross-listedarXiv:2609.31070•Sep 28, 2026•1 citation
With the expansion of complex transport infrastructure, new paths for linking different destinations have emerged, allowing the definition of multiple routes. The introduction of new roads may also lead to disruptions in traffic flow. This problem can be generalized into a special case of VRP, which aims to find the optimal route for a fleet of vehicles within a network of destinations. Finding solutions to this problem requires an exponential number of operations, hindering the ability of exact solvers to deal with large instances, which must therefore be tackled using heuristics, often leading to suboptimal results. Quantum-based algorithms may allow us to find exact solutions in polynomial time with high probability, offering a potential future alternative to classical solvers and in this work, we focus on the QAOA. Our novel contributions are a parameter-initialization strategy that improves the convergence probability and the integration of the subtour constraints directly into the optimization without using additional qubits by employing an approximation of exponential equality constraints. We believe that our results pave the way for effectively solving instances of VRP using quantum-based solutions, leveraging the space-efficient problem encoding and our initialization strategy, which limits the effect of barren-plateau under random parameter initialization.
Quantum Machine Learning is a novel field of research aimed at devising machine learning approaches exploiting principles of quantum mechanics, such as superposition, entanglement and interference. In this context, we present a scalable hybrid Quantum Diffusion Model, and evaluate its use for medical image analysis. Specifically, our method is based on a Discrete-Time Quantum Walk algorithm, executed on a real quantum device, to model the forward dynamics of the diffusion model. For the backward step of the diffusion model, we devise and evaluate a classical learning model, which is used to reversely denoise the data. In contrast with other existing attempts at applying quantum machine learning for image analysis tasks, severely limited by the size of existing quantum devices, our method allows to process real-world large size medical data. In particular, we present results on grayscale and RGB images, as well as 3D volumes of moderate sizes. We benchmark our results by reproducing an alternative classical counterpart model, based on diffusion models on discrete state spaces. By doing so, we compare the generation capabilities of both models in terms of three distinct state-of-the-art metrics in the field of image generation, showing the competitive, promising results of our approach.