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Scientific Reports

Enhanced brain tumour prediction using quantum: a hybrid deep learning approach

K. Valarmathi, N. Aniruddhan, S H V Harsha Vardhan, D Vishaal

Published Jun 25, 2026• 1 citation
Publisher

Abstract

Brain tumours are very serious concerns in the health field; they should be diagnosed properly and at the right time to ensure treatment efficacy. While deep learning architectures like ResNet have shown remarkable success in medical imaging, they have their own set of disadvantages, like computational complexity, scalability, and difficulty in processing very high-dimensional medical data. To overcome these hurdles, a hybrid approach has been proposed, combining ResNet with quantum transfer learning, leveraging the embedding to achieve good performance with higher efficiency in the use of quantum computing technology. In this framework, ResNet extracts valuable features from MRI scans, while quantum circuits optimise the classification process, thereby improving performance and generalisation. The quantum component of the proposed model is implemented using the PennyLane framework, enabling seamless integration of quantum circuits with classical deep learning architectures through a hybrid quantum-classical learning paradigm. Extensive experiments show that our hybrid quantum/classical model outperforms all conventional deep learning approaches, achieving higher diagnostic accuracy while minimising computational overhead. Compared to a traditional CNN (a series of neurons processing unstructured data for machine-understandable form) model, which achieves only 82% accuracy, our hybrid model significantly outperforms it with 95% accuracy, representing a 14% increase in classification performance. Results indicate that quantum computing can transform radiology and medical imaging, providing the tools to advance human health and create a future of fast, precise, and scalable diagnostic equipment. This can be considered a huge step forward toward the use of quantum computing in the medical field; it opens another avenue for advanced medical diagnostics and better patient outcomes.

DOI
10.1038/s41598-026-51263-x

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This research presents a new hybrid model that combines the capabilities of a pre-trained ResNet-50 with a Quantum Neural Network (QNN) to enhance the classification of MRI brain images for tumor recognition. Combining conventional deep learning and quantum computing, this technique competes with traditional models regarding accuracy, speed, and computational effectiveness. The ResNet-50 architecture is the foundation for feature extraction, using its demonstrated ability to handle challenging MRI image data. ResNet-50's linear layer weights are converted into angular parameters to take advantage of the potential of quantum computing, allowing the quantum layer to function within a six-angle depth framework. This unique integration allows the model to efficiently execute binary classification and multi-class tumor detection. The hybrid model outperforms conventional models, providing quicker processing speeds and higher classification accuracy, especially when dealing with high-dimensional and noisy data. The model optimizes 512-dimensional data using four qubits, allowing for improved feature representation and better insights into complicated medical imaging patterns. The quantum layer's resistance to noise enhances the model's accuracy, establishing a new standard for medical diagnostic tools. This novel integration of classical and quantum approaches offers a significant advance in MRI-based tumor identification, providing higher performance and opening the path for next-generation medical imaging systems.
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Deep learning and quantum computing are used in the Hybrid Quantum CNN-ResNet152 Model for Enhanced Brain Tumor Diagnosis to make MRI-based brain tumor categorization more accurate. There is room for improvement in the performance of the commonly used traditional CNN and ResNet architectures (ResNet 50, ResNet 101, ResNet 152) in medical imaging. A comparison of various models in this research shows that CNN-ResNet152 outperforms them all with a score of 96.19% F1-score, 97.75% recall, 94.67% precision, and 89.8% accuracy. Data imbalance, computational complexity, and model generalization are still issues, however. One way to tackle this is by incorporating quantum computing methods like QCNN, QVC, and QFE into feature extraction and optimization processes. Hybrid quantum-classical models seem to be a game-changer in the field of medical artificial intelligence and quantum computing, since they considerably enhance brain tumor detection, leading to quicker diagnoses with less ambiguity and better patient outcomes.
Medical image classification is a critical task in computer-aided diagnostics, but classical deep learning models often demand substantial computational resources and large parameter spaces. This paper investigates the potential of hybrid quantum-classical neural networks to address this challenge in the context of multi-class brain tumor classification from MRI scans. We introduce a custom hybrid quantum machine learning (QML) model and conduct a rigorous comparative analysis against its purely classical counterpart, as well as established architectures such as ResNet-18 and VGG-16. Our findings demonstrate that the proposed hybrid QML model achieves a state-of-the-art test accuracy of 96.58%, matching the performance of the significantly larger ResNet-18 model. Crucially, the hybrid model outperforms its direct classical counterpart, the Classical Benchmark (96.20%), while utilizing approximately 80% fewer parameters. Although simulating quantum circuits results in longer training times, our findings highlight the remarkable parameter efficiency and competitive accuracy of hybrid quantum models, suggesting a promising direction for developing powerful yet lightweight networks for medical diagnostics.
Brain tumor detection from MRI images is a critical and challenging task in medical diagnostics, where early identification greatly improves treatment outcomes. This paper presents a Hybrid Quantum– Classical Convolutional Neural Network (HQCNN) that integrates the strengths of ResNet-18 and a Variational Quantum Circuit for efficient and accurate tumor classification. The proposed model first employs ResNet-18 as a classical feature extractor, where 17 convolutional layers and pooling operations capture both low-level and high-level spatial features from MRI images. The final fully connected layer of ResNet-18 is replaced by a quantum processing layer implemented using PennyLane. In this layer, the extracted classical features are encoded onto qubits using RY rotation gates, while CNOT gates introduce entanglement between them, forming a VQC with trainable parameters. After quantum computation, Pauli-Z measurements convert the processed quantum states back into classical values, which are passed to a final fully connected layer for binary classification as Tumor or No Tumor. The hybrid integration of classical CNN feature learning with quantum entanglement– based representation enhances model generalization and interpretability. Experimental analysis demonstrates that the proposed HQCNN achieved 94.65% accuracy, outperforming traditional CNN models and confirming the potential of hybrid quantum–classical architectures for reliable and interpretable medical image diagnosis.
Accurate classification of glioma grades from magnetic resonance imaging (MRI) is essential for clinical decision-making in neuro-oncology. Although deep learning performance has been impressive with classical models, they struggle with high-dimensional medical imaging data and generalise poorly beyond their training data, especially in time- and resource-constrained settings. In light of the aforementioned challenges, we propose QuantumMedDx, a hybrid quantum–classical learning framework for classifying gliomas using MRI. The framework combines quantum feature encoding and variational quantum circuits with classical neural inference to improve diagnostic performance. The base model, QImageNet, uses amplitude-based quantum encoding for writing, entanglement-enabled parameterised quantum circuits (EPQCs) as feature extractors, and classical dense layers for classifying HGG and LGG from multimodal MRI slices. We demonstrate the effectiveness of the proposed approach on the BraTS 2021 benchmark dataset using a patient-aware 5-fold cross-validation protocol. Experimental results show that QuantumMedDx achieves accuracies of 94.12%, 93.30%, and 96.42%; F1-scores of 93.30% and 96.42%; and AUCs of 96.42% and 96.42%, respectively, outperforming conventional CNN, DNN, and SVM baselines. Ablation studies provide additional evidence of the performance improvements enabled by quantum Fourier transform and entanglement layers. Such results suggest that quantum–classical learning can efficiently improve feature extraction and discrimination in medical imaging, thus providing a modular and scalable route towards quantum–inspired clinical decision–support systems of the future.