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Advanced imaging.

Quantum illumination for scanning imaging under amplitude and phase noise

Jing Gao, Zhiming Qing, Jing Wang, He Jiang, Ming Zhang, Wenzheng Zhu, Hao Li, Huang Shuangyin, Jiamin Xu, Zhicheng Ren, Jianping Ding, Xilin Wang, Huitian Wang

Published Jan 1, 2026• 0 citations
Publisher
DOI
10.3788/ai.2026.10006

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Laser scanning microscopy (LSM) is known to be the workhorse for modern life-science, it allows to get new insights into a variety of biological processes. LSM together with illumination in the mid infrared region (Mid-IR) permits to map the chemical composition of samples to a space frame. However, low-light observations in the Mid-IR spectrum are still challenging and a limiting factor for a faster development. A label-free quantum scanning imaging system is presented here, capable of performing the detection in the visible regime, while the illumination is carried out in the Mid-IR region. Our quantum imaging with undetected light implementation aims to retrieve amplitude and phase images of biological samples containing a variety of functional groups that are present in the Mid-IR region
Entangled photons have the remarkable ability to be more sensitive to signal and less sensitive to noise than classical light. Joint photons can sample an object collectively, resulting in faster phase accumulation and higher spatial resolution, while common components of noise can be subtracted. Even more, they can accomplish this while physically separate, due to the nonlocal properties of quantum mechanics. Indeed, nearly all quantum optics experiments rely on this separation, using individual point detectors that are scanned to measure coincidence counts and correlations. Scanning, however, is tedious, time consuming, and ill-suited for imaging. Moreover, the separation of beam paths adds complexity to the system while reducing the number of photons available for sampling, and the multiplicity of detectors does not scale well for greater numbers of photons and higher orders of entanglement. We bypass all of these problems here by directly imaging collinear photon pairs with an electron-multiplying CCD camera. We show explicitly the benefits of quantum nonlocality by engineering the spatial entanglement of the illuminating photons and introduce a new method of correlation measurement by converting time-domain coincidence counting into spatial-domain detection of selected pixels. We show that classical transport-of-intensity methods are applicable in the quantum domain and experimentally demonstrate nearly optimal (Heisenberg-limited) phase measurement for the given quantum illumination. The methods show the power of direct imaging and hold much potential for more general types of quantum information processing and control.
G.Ortolano,A.Paniate,P.Boucher,C.Napoli,S.Soman,S.Pereira,I.Ruo Berchera,M.Genovese The peculiar properties of quantum optical states represent a new resource for innovative imaging schemes [1], as sub-shot noise imaging [2] or quantum illumination [3]. Here, after a general introduction, we present a work where photon number entanglement is exploited to enhance imaging of a pure phase object in a non-interferometric setting. Our method provides the absolute value of the phase without prior knowledge of the object operating in wide-field mode, so it does not need time-consuming raster scanning. Besides a general improvement of the image quality at a fixed number of photons irradiated through the object, we demonstrate a clear reduction of the uncertainty in the quantitative phase estimation. Significant application, in particular in biology, can be envisaged. [1] M.Genovese, J.of Optics, 18 (2016) 073002 [2] G.Brida et al., Nat.Phot. 4, 227 (2010). N.Samantaray et al. Light: Sc.&App.(2017) 6, e17005 [3] E.Lopaeva et al.,PRL 110, 153603 (2013)