A Comparative Analysis and Predictive Study of Deep Learning-Based Hybrid Quantum Error Mitigation Techniques for Noisy Intermediate-Scale Quantum Devices
Quantum computing represents one of the most transformative technological developments of the twenty-first century. However, the practical realization of its potential on current Noisy Intermediate-Scale Quantum (NISQ) hardware remains severely constrained by noise and computational errors that arise from the inherent fragility of quantum states. This paper presents a systematic comparative analysis of three prominent quantum error mitigation techniques, partial quantum error correction (QEC), zero-noise extrapolation (ZNE), and deep learning-based noise prediction, and develops a predictive assessment of a proposed hybrid framework that integrates all three into a unified system. Through a thorough review of twelve peer-reviewed publications spanning 2017 to 2026, we establish what each technique has accomplished individually and to what degree of accuracy. We identify a critical and previously unaddressed gap: no existing work has systematically combined these three complementary approaches. Drawing on documented performance trends and theoretical complementarity, we predict that a well-designed hybrid framework could achieve classification accuracies of 85 to 90 percent on standard quantum machine learning benchmarks, compared to only 60 to 65 percent without error mitigation. These predictions are grounded in peer-reviewed experimental data. Our analysis provides a clear evidence-based roadmap for future experimental validation and establishes a strong foundation for the development of practical, resource-efficient quantum machine learning systems on near-term hardware. CCS Concepts: Hardware → Quantum computation; • Computing methodologies → Machine learning; • Theory of computation → Quantum complexity theory
Quantum computing represents one of the most transformative technological developments of the twenty-first century. However, the practical realization of its potential on current Noisy Intermediate-Scale Quantum (NISQ) hardware remains severely constrained by noise and computational errors that arise from the inherent fragility of quantum states. This paper presents a systematic comparative analysis of three prominent quantum error mitigation techniques, partial quantum error correction (QEC), zero-noise extrapolation (ZNE), and deep learning-based noise prediction, and develops a predictive assessment of a proposed hybrid framework that integrates all three into a unified system. Through a thorough review of twelve peer-reviewed publications spanning 2017 to 2026, we establish what each technique has accomplished individually and to what degree of accuracy. We identify a critical and previously unaddressed gap: no existing work has systematically combined these three complementary approaches. Drawing on documented performance trends and theoretical complementarity, we predict that a well-designed hybrid framework could achieve classification accuracies of 85 to 90 percent on standard quantum machine learning benchmarks, compared to only 60 to 65 percent without error mitigation. These predictions are grounded in peer-reviewed experimental data. Our analysis provides a clear evidence-based roadmap for future experimental validation and establishes a strong foundation for the development of practical, resource-efficient quantum machine learning systems on near-term hardware. CCS Concepts: Hardware → Quantum computation; • Computing methodologies → Machine learning; • Theory of computation → Quantum complexity theory
Abstract Quantum computing has recently emerged as a novel paradigm for solving problems otherwise intractable on classical computers, yet the practical progress of quantum computers is severely impacted by noise, decoherence, and imperfect gate operations in Noisy Intermediate-Scale Quantum (NISQ) devices. Specific to IBM Quantum hardware, imperfections due to readout error, gate errors, and device drift, which depends on time, resolves limits for the accuracy of outputs from our algorithms. The mitigation strategies currently used, for example, Measurement Error Mitigation (MEM), Zero Noise Extrapolation (ZNE), and Clifford Data Regression (CDR), offer improvement over raw, unmitigated outputs, but they are static and not dynamic; the reduction of noise in within an NISQ device is temporal and can vary in patterns that are non-zero. In addition to this, using the conventional methods provides inconsistent and suboptimal results.This study will provide enhanced reliability with respect to performing quantum computation on IBM Quantum hardware with a unique mitigation framework that is adaptive and computationally efficient for a high-fidelity output. The problem taken on here is the failure of existing error mitigation strategies to provide adaptive noise compensation, as they assume a statically-distributed error, despite the performance-related characteristics already being documented in regards to calibration drift and variation over time.To achieve this, we propose a Hybrid Adaptive Error Mitigation (HAEM) approach that includes baseline measurement error mitigation and an additional correction layer that utilizes realtime calibration information, along with lightweight machine learning models. The approach can be broken down into three steps: (i) perform standard measurement error mitigation to reduce classical readout noise, (ii) execute compact calibration circuits, such as Bell states, GHZ states and Clifford benchmarks to capture then current error profile of the device, and (iii) use a lightweight machine learning model (having been trained on historical and newest calibration data) to dynamically change the mitigation weights applied for the target quantum algorithm. All implementation is done using Qiskit Runtime to ensure low-latency execution, and we completed experiments on both Qiskit Aer noisy simulators and IBM Quantum devices.Initial results suggest HAEM improved the outputs of quantum algorithms' fidelity compared to the unmitigated runs and the baseline measurement error mitigation (MEM) runs. On the noisy simulators, HAEM increased fidelity from a raw performance of 0.65 to 0.87, nearly a 34% improvement. In fairer hardware-like scenarios, fidelity-on-average was persistently 12% better than MEM, with nearly equal time duration for the additional adaptive measurements. The adaptive aspect of HAEM consistently supported subsequent calibration cycles of the device and was effective to continue providing fidelity improvements despite the static mitigation performance degrading.To sum up, the proposed HAEM framework is a modern and viable alternative for error mitigation which brings together the benefits of baseline approaches with corrections that are driven by fixed-function error-corrective, adaptive learning. As both learning-based and standard baseline approaches can only achieve fixed levels of performance, HAEM, through its use of noise mitigation both at execution time and through correlating it with standard data, provides a route towards reliable quantum computations on current IBM hardware. HAEM also presents a contribution to the NISQ error-resilient landscape, and however it is intended that it will continue to improve future applications of hybrid workflows of quantum and classical computation where error mitigation and resilience is important.
The pursuit of high-fidelity digital quantum simulation is fundamentally constrained by the inevitable presence of noise in current and near-term quantum processors. While quantum error correction ultimately promises fault-tolerance, its substantial qubit overhead renders it impractical for the noisy intermediate-scale quantum (NISQ) era. This research addresses the critical gap between hardware imperfections and simulation accuracy by designing systematic, resource-efficient machine learning (ML) error-mitigation protocols tailored specifically for digital quantum simulation. Unlike generic error-suppression methods, our approach exploits the unique structural properties of simulated quantum dynamics—including time-translation invariance, locality of interactions, and conserved quantities—to inform the training of lightweight neural networks and Gaussian process regressors. We develop a hybrid framework that combines randomized compiling with data-driven noise-inversion models, enabling real-time estimation and subtraction of both coherent and incoherent errors without exponential sampling overhead. Through extensive numerical benchmarks on spin-chain and Fermi-Hubbard models, we demonstrate that our ML protocols achieve up to an order-of-magnitude reduction in infidelity compared to standard probabilistic error cancellation and zero-noise extrapolation, while requiring fewer calibration circuits. Furthermore, we introduce an adaptive online learning scheme that continuously refines the mitigation model during the simulation runtime, automatically adjusting to time-dependent drift in hardware noise. Our results establish a practical pathway toward scalable, high-accuracy quantum simulations on existing devices, with implications for condensed matter physics, quantum chemistry, and the development of quantum advantage benchmarks.
Performance Optimization of Noise-Mitigated Quantum-Classical Hybrid Classifiers via Zero-Noise Extrapolation in NISQ Environments Overview Near-Term Intermediate-Scale Quantum (NISQ) hardware remains heavily constrained by physical noise, gate infidelities, and decoherence, which severely degrade the performance of Variational Quantum Classifiers (VQCs). This research presents an end-to-end, noise-mitigated hybrid quantum-classical machine learning pipeline that integrates PyTorch classical layers with PennyLane parameterized quantum circuits (PQCs) and applies Zero-Noise Extrapolation (ZNE) via Mitiq to counteract hardware noise. Key Highlights & Contributions Modular Hybrid Architecture: Combines classical feature mapping and post-processing in PyTorch with parameterized quantum variational circuits built in PennyLane. Digital Error Mitigation: Evaluates global gate folding (G→GG†G) across varying scale factors (λ∈{1,3,5}) to extrapolate expectation values back to the zero-noise limit. Accuracy Recovery: Demonstrates that ZNE recovers classification accuracy near ideal noiseless performance (98.5%) under low-to-moderate depolarizing noise levels (p < 0.01), outperforming unmitigated noisy executions by up to 11.3%. Model Benchmarking: Directly compares linear and second-order polynomial extrapolation models, analyzing variance trade-offs under finite shot noise constraints. Repository & Code Contents This deposit includes the full PDF manuscript alongside the accompanying code archive: Noise_Mitigated_Quantum_Classical_Hybrid_Classifier_with_Zero_Noise_Extrapolation.pdf — Full IEEE-formatted research paper. Noise-MitigatedQuantum-ClassicalHybridClassifierwithZero-NoiseExtrapolation.ipynb — Executable Jupyter Notebook containing the full PyTorch–PennyLane–Mitiq benchmarking pipeline. requirements.txt & README — Environment setup and reproduction instructions. How to Cite If you find this work or codebase helpful for your research in Quantum Machine Learning (QML) or Quantum Error Mitigation (QEM), please cite this preprint using the Zenodo DOI provided above.
Quantum Neural Networks (QNNs) represent a promising direction within Quantum Machine Learning (QML), yet their realization on noisy intermediate-scale quantum (NISQ) devices remains constrained by decoherence, gate imperfections, crosstalk, and readout errors. This study provides a systematic evaluation of noise effects and mitigation strategies in hybrid quantum neural networks (HQNNs). Zero-Noise Extrapolation (ZNE), Digital Dynamical Decoupling (DDD), and Layerwise Richardson Extrapolation (LRE) are incorporated into end-to-end QNN training pipelines developed with PennyLane, simulated using Qiskit Aer noise models, and integrated with the Mitiq framework, while Probabilistic Error Cancellation (PEC) is evaluated separately under depolarizing noise due to its computational cost. Experiments conducted on the Iris dataset with five representative noise channels show that the impact of noise and the effect of mitigation are strongly dependent on the noise model and its strength. The model maintains comparatively strong performance under phase-flip and phase-damping noise, while substantial degradation is observed under high depolarizing and amplitude-damping noise. Across the evaluated mitigation methods, the observed benefits remain limited and noise-dependent: ZNE, DDD, and LRE generally follow the same degradation trends as the unmitigated baseline, while PEC shows limited gains only in the low-noise depolarizing regime. These findings highlight the need for context-specific mitigation strategies to improve the robustness of QNNs in practical NISQ settings.
Quantum computing has emerged as a transformative paradigm capable of addressing computational challenges beyond the reach of classical systems.In the current era of Noisy Intermediate-Scale Quantum (NISQ) devices, practical quantum hardware is characterized by limited qubit counts, short coherence times, gate errors, and the absence of full error correction.Despite these constraints, significant progress has been made in developing quantum machine learning (QML) techniques tailored to operate on near-term quantum processors.This paper presents a comprehensive review of Quantum Machine Learning in the context of NISQ computing.We first outline the fundamental principles of quantum computing, including qubits, superposition, entanglement, and quantum parallelism, followed by a detailed discussion of the NISQ computing model and its hardware limitations.The review then examines hybrid quantum-classical learning frameworks, variational quantum algorithms, quantum data encoding strategies, and noise mitigation techniques that enable practical implementation on existing platforms.Emerging applications across healthcare, finance, cybersecurity, climate modeling, and materials science are also surveyed to highlight the real-world potential of QML.Furthermore, key challenges such as scalability, trainability issues, and algorithmic robustness are analyzed, along with current research efforts aimed at overcoming these barriers.The paper concludes by identifying promising future directions for advancing QML toward quantum advantage.This review aims to provide researchers and practitioners with a structured understanding of the capabilities, limitations, and opportunities of quantum machine learning in the NISQ era .
Noise in quantum hardware is the primary obstacle to realizing the transformative potential of quantum computing. Quantum error mitigation (QEM) offers a promising pathway to enhance computational accuracy on near-term devices, yet existing methods face a difficult trade-off between performance, resource overhead, and theoretical guarantees. In this work, we introduce neighbor-informed learning (NIL), a versatile and scalable QEM framework that unifies and strengthens existing methods such as zero-noise extrapolation (ZNE) and probabilistic error cancellation (PEC), while offering improved flexibility, accuracy, efficiency, and robustness.
NIL learns to predict the ideal output of a target quantum circuit from the noisy outputs of its structurally related ``neighbor'' circuits. A key innovation is our 2-design training method, which generates training data for our machine learning model. In contrast to conventional learning-based QEM protocols that create training circuits by replacing non-Clifford gates with uniformly random Clifford gates, our approach achieves higher accuracy and efficiency, as demonstrated by both theoretical analysis and numerical simulation. Furthermore, we prove that the required size of the training set scales only \emph{logarithmically} with the total number of neighbor circuits, enabling NIL to be applied to problems involving large-scale quantum circuits. Our work establishes a theoretically grounded and practically efficient framework for QEM, paving a viable path toward achieving quantum advantage on noisy hardware.