The rapid expansion of clinical data in modern healthcare requires analytical systems capable of uncovering intricate patterns and supporting accurate diagnostic decisions. Quantum machine learning (QML) offers significant potential for modeling higher-order feature interactions and accelerating computation beyond classical approaches. This paper introduces an improved hybrid architecture that fuses an inception-based attentional VGG (IAV) network with a quantum variational classifier (QVC) constructed using parameterized quantum circuits (PQCs). The framework begins with min-max normalization to stabilize heterogeneous clinical attributes and enhance training convergence. Deep discriminative features are then extracted through the IAV model, followed by quantum-driven classification using variational layers optimized by classical routines. The MIMIC-III clinical dataset is employed to validate the proposed system on large-scale healthcare records. Performance is measured using accuracy, precision, recall, and F1-score. The enhanced hybrid model achieves 97.28% accuracy, 97.16% precision, 96.65% recall, and a 97.38% F1-score, surpassing established methods including support vector machine (SVM) (89.23%), quantum support vector machine (QSVM) (90.13%), and QVKSVM (97.34%). The findings confirm that integrating deep learning with quantum variational optimization strengthens scalability, reduces computational overhead, and establishes a powerful foundation for next-generation healthcare analytics.
The rapid expansion of clinical data in modern healthcare requires analytical systems capable of uncovering intricate patterns and supporting accurate diagnostic decisions. Quantum machine learning (QML) offers significant potential for modeling higher-order feature interactions and accelerating computation beyond classical approaches. This paper introduces an improved hybrid architecture that fuses an inception-based attentional VGG (IAV) network with a quantum variational classifier (QVC) constructed using parameterized quantum circuits (PQCs). The framework begins with min-max normalization to stabilize heterogeneous clinical attributes and enhance training convergence. Deep discriminative features are then extracted through the IAV model, followed by quantum-driven classification using variational layers optimized by classical routines. The MIMIC-III clinical dataset is employed to validate the proposed system on large-scale healthcare records. Performance is measured using accuracy, precision, recall, and F1-score. The enhanced hybrid model achieves 97.28% accuracy, 97.16% precision, 96.65% recall, and a 97.38% F1-score, surpassing established methods including support vector machine (SVM) (89.23%), quantum support vector machine (QSVM) (90.13%), and QVKSVM (97.34%). The findings confirm that integrating deep learning with quantum variational optimization strengthens scalability, reduces computational overhead, and establishes a powerful foundation for next-generation healthcare analytics.
Diagnosing multimodal medical conditions necessitates seamlessly integrating the insights of both medical images and physiological signals, aiming to boost disease detection accuracy and efficiency in clinical decision making. However, existing deep learning models struggle to exploit sophisticated cross-modal relations and higher-order feature interactions efficiently and computationally. To overcome such shortcomings, we propose a Quantum-Deep Hybrid Architecture to jointly learn the healthcare signal and image features by incorporating Variational Quantum Circuits (VQCs) into a combined architecture based on Convolutional Neural Networks (CNNs) and 1D-CNNs. In our approach, medical image data and physiological signal data pass through distinct CNN and 1D-CNN branches to extract spatial and temporal features, respectively. These encoded, lower-dimensional feature vectors are encoded into quantum states via angle encoding and learn quantum-enhanced features via a Variational Quantum Circuit. The derived quantum and classical features are fused via fully connected layers and a softmax activation function for classification. Moreover, we exploit the Bayesian optimization to select the optimum hyper-parameters and integrate both privacy-preserving feature encoding and secure data processing into the framework. Empirical evaluation results reveal that the developed model achieves overall classification accuracy, precision, recall, F1-score of 94.8%, 95.1%, 94.3%, 94.7%, respectively, with an average AUC of 0.968, surpassing the contemporary CNN and multimodal deep learning baselines. Our proposed hybrid model also shows competitive performance under varying levels of noise and demonstrates excellent stability. The results also suggest the developed framework offers an efficient, robust and scalable approach to next-generation multimodal healthcare analytics and intelligent clinical decision-making systems.
The healthcare systems produce a tremendous volume of medical data which may be in the form of patient records, laboratory test results and diagnostic reports. It is quite necessary to analyze such data accurately and efficiently in order to detect diseases early and plan appropriate treatment . Conventional machine learning methods have a tendency to struggling with large-dimensional and complicated medical data. To address these shortcomings, this project suggests a hybrid Quantum Machine Learning (QML) scheme of analyzing medical data and diagnosing a disease. The suggested system combines the classical data preprocessing with the quantum-enhanced data learning algorithms including Variational Quantum Circuits (VQC) and Quantum Support Vector Machines (QSVM). Medical data is first processed by cleaning, normalizing and encoding to quantum states. Complex patterns and correlations that traditional algorithms can hardly be able to learn are then learned with the quantum model. The measures used to judge the performance are accuracy, precision, recall and F1-score. The results of the experimental process show that the model based on QML yields better diagnostic accuracy than the conventional machine learning. This is where there is great potential in real time medical decision support systems, with the future prediction of disease and the personalized solution of care. The suggested framework indicates the potential and benefits of switching to quantum computing methods in healthcare analytics.
Abstract Neuro-imaging data is necessary for timely and correct diagnosis of the disease Alzheimer’s (AD). Early clinical intervention is challenging due to the high-dimensional nature of the images, making it computationally difficult to work on representations, sparse annotated datasets and inter-subject variance. Deep convolutional VGG, ResNet, DenseNet, MobileNet and other neural networks (CNNs) have shown good performance. Diagnostic performance, but they are based on a high number of parameters and require highly trained personnel. Data can often times restrict resilience to data-skimy clinical settings. To address these challenges, the current paper presents a hybrid Quantum Machine Learning (QML) architecture for Alzheimer’s disease Detection and classification based on a combination of classical CNN-based feature extraction and Variational quantum classifier. In the suggested method, diseased, relevant, and compact features are extracted using pre-trained CNN backbones. Data from structural MRI scans is later translated into quantum states and computed. With parameterised variational quantum circuits optimised with a hybrid quantum-classical learning loop. The proposed method has been experimentally evaluated on benchmark datasets of MRI scans of Alzheimer’s patients. The hybrid CNNQML model has a mean classification accuracy of about 93% which is similar to deep CNN models, including ResNet and DenseNet (94%), and much more. Beating lightweight models like MobileNet and shallow CNNs by six percentage points. It is worth noting that the hybrid QML model performs better in conditions with limited training data. Performance degradation is observed in accuracy and AUC for all CNN variants, with up to 5% lower performance to deep CNNs. Cross-validation, confidence interval, paired significance test, and statistical validation. Effect size analysis proves the fact that the hybrid model produces statistically significant performance, as well as cases of clinically meaningful improvements over lightweight CNN baselines. Similar to the state-of-the-art deep networks with significantly reduced trainable parameters in the classification stage. These findings show that hybrid QML is a data-efficient and powerful substitute in the diagnosis of Alzheimer’s. On the whole, this is a work that sets a practical way to integrate quantum machine learning into clinical neuro-imaging pipelines and hybrid settings. QML has supplementary deep-learning enhancement to classics in next-generation Alzheimer’s Decision-support systems.
This research presents a novel quantum-hybrid machine learning framework for heart disease classification that integrates Quantum Neural Networks with variational circuits and Quantum Support Vector Machines featuring custom quantum kernels alongside classical ensemble methods. The methodology employs advanced feature engineering, multi-strategy missing value imputation, and combined feature selection techniques on an enhanced dataset of 2,000 cardiovascular cases with 17 engineered features. The quantum components utilize 8-10 qubits across 5-6 variational layers with quantum interference effects for enhanced pattern recognition capabilities. Through weighted soft voting ensemble strategy and dynamic threshold optimization, the quantum-hybrid system achieved exceptional performance metrics including 96.2% accuracy, 95.8% F1-score, 94.7% precision, and 96.9% recall, significantly exceeding the 95% accuracy target. The quantum models demonstrated measurable advantages over classical approaches, with the Quantum Neural Network reaching 92.4% accuracy and Quantum SVM achieving 90.8% accuracy independently. The hybrid ensemble showed 4.3 percentage points improvement over the best individual classical model and 2.7 percentage points over standalone quantum implementations. This quantum-hybrid approach establishes superior diagnostic capabilities for cardiovascular disease prediction, particularly in minimizing false negatives critical for patient safety, positioning quantum-enhanced machine learning as a viable solution for next-generation medical diagnostic systems with clinically relevant accuracy improvements for healthcare applications.
Purpose This study investigates the integration of quantum-enhanced machine learning (QML) into medical image analysis, focusing on classification and feature extraction tasks. It aims to evaluate whether hybrid quantum-classical models can overcome the limitations of traditional machine learning in handling high-dimensional, clinically relevant imaging data. Design/methodology/approach Hybrid architectures combining classical preprocessing with quantum components, specifically variational quantum circuits (VQCs) and quantum kernel methods, were developed and implemented in simulated quantum environments using Qiskit and PennyLane on Google Colab. Publicly available datasets (ChestX-ray14, Brain Tumor MRI and CT Hemorrhage) were preprocessed and encoded into quantum states. Model performance was evaluated against classical baselines (MLP and CNN) using accuracy, precision, recall, F1-score, convergence speed and trainable parameters. Findings Quantum-enhanced models achieved competitive or superior performance compared to classical models with significantly fewer trainable parameters and faster convergence. The Quantum Kernel SVM demonstrated the highest precision (89.1%) and F1-score (88.5%) using only 8 parameters, while VQC models converged up to 2× faster than classical baselines. These results highlight the potential of QML to improve efficiency, robustness and scalability in diagnostic imaging workflows, particularly in resource-constrained or data-limited settings. Research limitations/implications The study relies on simulated quantum environments, which do not capture hardware noise or qubit limitations. Future work will extend to real quantum devices, multimodal data integration and interpretability strategies. Practical implications Quantum kernel methods and lightweight VQC architectures enable faster, resource-efficient diagnostic modeling, making them suitable for clinical environments with limited computational capacity or time-sensitive decision-making needs. Social implications Improving the efficiency and accessibility of medical image analysis has the potential to support faster diagnosis and enhance healthcare delivery, particularly in underserved or resource-limited regions. Originality/value This study provides a practical evaluation of hybrid quantum-classical models applied to multiple real medical imaging datasets in a reproducible simulated environment. It offers an early-stage framework demonstrating how QML techniques can be integrated into existing machine learning pipelines for medical image analysis.
Early diagnosis of chronic diseases is paramount to improving patient survival rates, optimizing treatment trajectories, and mitigating escalating healthcare expenditures. While the recent explosion of heterogeneous healthcare data presents robust opportunities for predictive modeling, it simultaneously introduces severe computational bottlenecks regarding data dimensionality and non-linear complexity. This paper proposes a novel, high-performance hybrid prediction framework that seamlessly fuses classical machine learning topologies with Variational Quantum Circuits (VQCs) within a Quantum Machine Learning (QML) paradigm. The proposed architecture targets the multi-classification and risk profiling of five high-prevalence chronic conditions: diabetes, cardiovascular disease, breast cancer, chronic liver disease, and chronic kidney disease This project introduces “Quantum Health,” a Quantum Machine Learning (QML)-based multi disease prediction system that integrates classical and quantum computing to enhance diagnostic performance. It employs five quantum-enhanced models: Quantum Random Forest for breast cancer, Quantum Neural Network for diabetes, Quantum k-Nearest Neighbors (QkNN) for heart disease, Quantum AdaBoost for liver disease, and Quantum Naive Bayes for kidney disease. The models are evaluated using both classical methods and PennyLane simulations, enabling direct comparison of performance. The system is deployed as a Flask-based web application featuring a user-friendly dashboard, disease-specific prediction modules, prediction history with CSV export, and an analytics dashboard comparing classical and quantum accuracies. Each module provides predictions, confidence scores, and feature importance insights. Unlike monolithic classical models, our approach incorporates a parameterized quantum layer that maps low-dimensional classical medical vectors into high-dimensional Hilbert spaces, capturing intricate, non-linear correlations that evade classical kernels. Experimental evaluations executed on simulated quantum backends demonstrate that the proposed Quantum Hybrid Model drastically outperforms conventional baselines, achieving an overall classification accuracy of 96.8% and an Area Under the Curve (AUC) of 98.4%. The findings establish that integrating quantum circuit state vectors with ensemble classical architectures provides a scalable, computationally efficient, and highly generalizable paradigm for next-generation clinical decision support systems.