This research introduces a quantum machine learning (QML) approach for predicting heart disease (HD). The method combines preprocessing of data with quantum feature map (QFM) and quantum classification techniques. In the method, clinical data of HD are preprocessed, and then features are optimized using principal component analysis (PCA). After that, the resulting features are encoded into quantum states with five different QFM methods, namely angle encoding (AE), amplitude encoding (AmE), basis encoding (BE), Pauli encoding (PE), and ZZ feature map (ZZFM). Finally, four quantum classifiers, such as quantum support vector machine (QSVM), quantum k-nearest neighbor (QKNN), quantum random forest (QRF), and variational quantum circuit (VQC), are evaluated to predict the HD from the encoded states. Experimental results show that QSVM with AE achieved the best performance, with an overall accuracy of 90.26%, specificity of 83.42%, sensitivity of 92.16%, precision of 88.89%, F1-score of 89.68%, and kappa value of 0.7608. These results are superior to those from classical state-of-the-art methods. This research finding suggests QML methods can capture complex nonlinear relationships in clinical data effectively and thus improve diagnostic reliability.
This research introduces a quantum machine learning (QML) approach for predicting heart disease (HD). The method combines preprocessing of data with quantum feature map (QFM) and quantum classification techniques. In the method, clinical data of HD are preprocessed, and then features are optimized using principal component analysis (PCA). After that, the resulting features are encoded into quantum states with five different QFM methods, namely angle encoding (AE), amplitude encoding (AmE), basis encoding (BE), Pauli encoding (PE), and ZZ feature map (ZZFM). Finally, four quantum classifiers, such as quantum support vector machine (QSVM), quantum k-nearest neighbor (QKNN), quantum random forest (QRF), and variational quantum circuit (VQC), are evaluated to predict the HD from the encoded states. Experimental results show that QSVM with AE achieved the best performance, with an overall accuracy of 90.26%, specificity of 83.42%, sensitivity of 92.16%, precision of 88.89%, F1-score of 89.68%, and kappa value of 0.7608. These results are superior to those from classical state-of-the-art methods. This research finding suggests QML methods can capture complex nonlinear relationships in clinical data effectively and thus improve diagnostic reliability.
Heart disease continues to be among the top causes of death globally, and thus precise and timely detection mechanisms are necessary for successful clinical intervention. This chapter introduces a sophisticated predictive model integrating quantum-enhanced feature extraction with classical and quantum machine learning (QML) models to enhance prediction accuracy and reliability of heart disease. Quantum models like quantum random forest (QRF), quantum k-nearest neighbor (QKNN), and quantum gradient boosting classifier (QGBC) are used in conjunction with traditional models like XGBoost and SVM to investigate hybrid computational synergies. The method utilizes quantum feature mapping and entanglement-based encoding to identify intricate nonlinear patterns present in cardiovascular data. A thorough performance comparison based on the UCI Heart Disease dataset shows that quantum-augmented models exhibit better predictive accuracy, precision, and F1-scores than conventional models. The findings support the potential of quantum computing to speed up healthcare analytics and make more accurate disease diagnosis possible. This work discusses the pioneering merger of quantum computing and machine learning as a revolutionary strategy for data-driven intelligent medical decision support systems.
Heart disease is one of the major global causes of death, requiring early and precise detection for efficient treatment.With advancements in quantum computing, Variational Quantum Circuits (VQCs) have gained recognition as a valuable technique for improving learning models in medical diagnosis.This study further explores the application of VQC-based models for heart disease prediction, leveraging quantum computing to enhance classification accuracy.A hybrid quantum-classical model has been developed, which combines classical preprocessing for feature extraction from patient datasets with a VQC-based classifier for medical predictions.The quantum circuit using variational parameters is optimized to reduce the loss function and facilitate effective learning from complex medical data.This proposed approach is tested on benchmark heart disease datasets and evaluated against classical Machine Learning (ML) models, including Support Vector Machines (SVMs), Random Forests, and Neural Networks.The experimental results show that VQC-based models achieve high accuracy and outperform classical models, notably on high-dimensional, non-linearly separable data.The quantum advantage of VQCs lies in their ability to encode and process data in a huge Hilbert space.However, challenges such as noise in near-term quantum devices and scalability issues remain key.This research underscores the efficacy of VQCbased quantum machine learning in medical diagnosis, paving the way for future studies on quantum-enhanced healthcare solutions.Further advancements in quantum hardware and hybrid learning techniques could allow quantum-assisted heart disease prediction to become an effective clinical tool.
Abstract Accurate early identification and treatment of cardiovascular diseases can prevent heart failure problems and reduce mortality rates. This study aims to use quantum learning to predict heart problems to increase the accuracy of traditional prediction and classification methods. Machine learning (ML) and deep learning (DL) techniques need quantum learning to quickly and accurately analyze massive volumes of complex data. With quantum computing, the suggested DL and ML algorithms can change their predictions on the basis of changes in the dataset. This approach could help with the early and accurate detection of chronic diseases. The Cleveland heart disease dataset is undergoing preliminary processing to validate missing values to increase the precision rate and prevent incorrect forecasts. This study examined the feasibility of employing and deploying a quantum ML (QML) framework via cloud computing to categorize cardiac conditions. The research was divided into four sections. First, the principal component analysis was used to preprocess the Cleveland dataset, recursive feature elimination was used to select features, and min–max normalization was used to give the dataset a high-dimensional value. Second, we compared traditional classifiers, such as support vector machine (SVM) and artificial neural network, with the quantum approach to verify the quantum approach’s efficiency. Third, we examined two unique QML classification methods: quantum neural networks (QNNs) and quantum SVM (QSVM). Fourth, bagging-QSVM was developed and deployed as an ensemble learning model. Experimental results using the QNN show an accuracy of 77%, a precision of 76%, a recall of 73%, and an F 1 score of 75%. With an accuracy of 85%, a precision of 79%, a recall of 90%, and an F 1-score of 84%, the QSVM method demonstrated a much better performance than the QNN. Particularly, the Bagging_QSVM model exhibited an outstanding performance, with a flawless score of 100% across all critical performance measures. The study shows that the bagging method for ensemble learning is a solid way of increasing the accuracy of quantum method predictions.
Heart disease remains a leading cause of mortality globally, driving interest in advanced computational methods forearly prediction. This study presents a comparative analysis of classical machine learning techniques versus a QuantumSupport Vector Machine (QSVM) for predicting heart disease using a specialized dataset featuring standard clinicalmetrics alongside a unique 'QuantumPatternFeature. 'We implemented and evaluated six classical algorithms (LogisticRegression, K-Nearest Neighbors, Decision Tree, Random Forest, Naive Bayes, Gradient Boosting), employingRandomizedSearchCV for hyperparameter optimization. For the quantum approach, a QSVC utilizing Qiskit'sZZFeatureMap (reps=2) and FidelityQuantumKernel was trained and tested using a classical simulator. A classicalSupport Vector Classifier (SVC) with an RBF kernel served as an additional baseline. Performance was assessed on a20% hold-out test set using accuracy, precision, recall, F1-score, and confusion matrices. Results indicate that tunedclassical models, particularly Logistic Regression and Gradient Boosting, achieved the highest accuracy (93.0%),significantly outperforming the simulated QSVC (79.0%). The classical SVC baseline also surpassed the QSVM with89.0% accuracy. Furthermore, the QSVM exhibited substantially higher computational times for both training andprediction on the simulator compared to all classical methods. The findings suggest that for this dataset size and thespecific simulated QSVM configuration, classical machine learning approaches offer superior performance andefficiency, and the 'QuantumPatternFeature' did not confer a discernible advantage within this quantum implementationframework.
Abstract Heart disease remains to be a primary cause of death globally, requiring precise and timely predictive methodologies. Traditional machine learning methods that depend exclusively on classical clinical variables frequently have restricted predictive accuracy and do not adequately use the intricate nonlinear interactions present in patient data. This work examines the effectiveness of hybrid quantum-classical models for predicting heart disease by combining classical clinical data with quantum-derived representations via Variational Quantum Classifier (VQC), Estimator, and Sampler models. Twelve hybrid configurations, integrating three quantum feature maps (Z, ZZ, Pauli) with four ansatz architectures (RealAmplitudes, TwoLocal, EfficientSU2, PauliTwoDesign), were assessed inside the PennyLane and Qiskit frameworks. The results indicate that the VQC model in PennyLane reached optimal performance with Z–TwoLocal and ZZ–PauliTwoDesign configurations, achieving accuracy and F1-scores of up to 0.95. The Estimator model consistently produced reliable predictions, with Pauli–EfficientSU2 and Z–TwoLocal attaining accuracies of up to 0.91 and F1-scores of 0.92 across several frameworks. The Sampler model demonstrated 1reasonable performance, with the Pauli–EfficientSU2 configuration achieving an accuracy of 0.65 and an F1-score of 0.73, underscoring the supplementary role of stochastic quantum sampling. The analysis of feature significance indicated that the quantum-derived feature provided the most robust predictive signal, exceeding classical variables like Age, Blood Pressure, and Cholesterol. These findings demonstrate that meticulous alignment of feature maps and ansatz circuits is essential for optimizing model expressivity, convergence, and predictive effectiveness. In summary, hybrid quantum-classical models, especially the Estimator and VQC architectures, significantly improve heart disease prediction, providing a feasible method for precision clinical decision support and potential incorporation into privacy-preserving, multi-institutional healthcare systems.
Heart disease remains one of the most critical global health concerns, creating a strong need for intelligent and accurate prediction systems. Even while conventional machine learning (ML) has shown promise, handling large and complex medical datasets often reduces the efficiency of traditional machine learning systems. Using a cloud-supported quantum framework, we present a hybrid diagnostic framework that compares three quantum architectures—QSVM, VQC, and QCNN—with five classical algorithms: Random Forest, SVM, KNN, Logistic Regression, and Gradient Boosting. The framework includes a cloud-managed preprocessing stage that uses PCA to map high-impact features, like blood pressure and cholesterol, onto an optimized qubit space in order to overcome the resource limitations of existing NISQ devices. To test the models, the Heart-Disease data set was applied, where classical algorithms demonstrated exceptional performance ranging between 70% to 75%. Specifically, because of the high precision of 0.81, VQC proved to possess remarkable performance on optimized data sets.