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International Conference on Innovative Trends in Information Technology (ICITIIT)

Comparative Analysis of Quantum and Multi-Model Deep Learning Approaches for Skin Lesion Classification

Sireesha Moturi, Chinnapareddy Anjali Reddy, Dogiparthi Dhanusha, Shaik Chikli Asifa, Chandra Mouli Kathi, Sasidhar Bola

Published Mar 27, 2026• 0 citations
Publisher

Abstract

In medical image analysis, skin lesion classification is a crucial problem since early detection can greatly lower health risks. The possibility of using quantum machine learning to replace traditional deep learning models has been studied recently.This study is positioned as a comparative benchmarking analysis to empirically evaluate the practical performance of quantum-based learning models against established deep learning architectures under identical experimental conditions.In this work, a renowned research technique was used to first create a Quantum Neural Network (QNN) and a Quantum Support Vector Classifier (QSVC). Many conventional deep learning models were then employed for comparison because of simulator limitations and poor performance. To provide a fair experimental setting, EFAM-Net, MobileNetV3, ResNet18, and EfficientNet-B0 were trained and assessed using the same dataset. Classical deep learning models performed better than quantum-based models, which had a modest classification accuracy of 62-65 %. ResNet18 and EFAM-Net had validation accuracy of 83.62 % and 79.89 %, respectively, while EfficientNet-B0 had the greatest validation accuracy of 90.21 %, closely followed by MobileNetV3 with 90.15 %. These findings suggest that conventional deep learning models are now more appropriate for real-world medical image categorisation since they provide more accuracy and training stability than quantum-based methods.

DOI
10.1109/icitiit68860.2026.11499483

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Breast cancer is a major health concern, and early detection can make a great difference in treatment and survival rates for breast cancer patients. Machine learning methods have noticeably improved prediction accuracy on high-dimensional medical datasets and have become widely used tools in medical diagnostics. The transition to a quantum computational framework has opened new directions in machine learning research. By using qubits instead of classical bits, quantum models may provide new ways to represent and process complex medical data. In medical diagnostics, this has led to a growing interest in whether quantum approaches can improve classification performance more effectively than classical methods. The purpose of this paper is to compare classical and quantum machine learning models on the task of breast cancer classification and to determine whether quantum models can achieve higher accuracy and faster prediction on a selected dataset. Alongside the main simulator-based experiment, a smaller experiment was performed on a real IBM quantum computer to demonstrate the practical execution of the same task under current hardware constraints. In the practical part of the study, the Wisconsin Diagnostic Breast Cancer (WDBC) dataset was used. This dataset consists of 569 samples with 30 numerical features extracted from digitized fine needle aspirate images and provides a reliable basis for evaluating model performance. A comparative analysis was conducted between classical and quantum machine learning models, including a support vector machine (SVM), an artificial neural network (ANN), a quantum support vector machine (QSVM), and a hybrid quantum-classical neural network (QNN). In the simulator-based experiment, both SVM and ANN achieved an accuracy of 0.956 with an F1-score of 0.965 on the test set, while QSVM reached an accuracy of 0.807 with an F1-score of 0.866 and the Hybrid QNN achieved 0.623 accuracy with an F1-score of 0.677. These quantum and hybrid models also required substantially longer training times than the classical baselines. A small hardware experiment on an IBM quantum device further illustrates both the practical feasibility and the current limitations of executing this classification task on noisy intermediate-scale quantum hardware.