Standard Zero-Noise Extrapolation (ZNE) in Variational Quantum Eigensolvers (VQE) assumes a single global noise scaling parameter, failing to capture heterogeneous and non-linear noise propagation across layered quantum circuits. We simulate VQE parameter optimisation at a challenging L=6 hardware-efficient depth, extracting the exact expectation values at each iteration. When the optimal parameters theta_star are found, they are fixed, and the multi-parameter noise surface is mapped. We propose a multi-parameter noise framework, modeling expectation values as a function of layer-wise noise scaling factors E(lambda_1, lambda_2, ..., lambda_L). Using structured unitary folding U_l = U_l (U_l^dagger U_l)^((lambda_l - 1) / 2), we independently scale the noise contribution of each ansatz layer and empirically map the resulting multi-dimensional noise surface. We analyze the separability of inter-layer noise interactions, identify layers with disproportionate error contributions via the gradient dE/dlambda_l, and compare scalar ZNE with multivariate polynomial regression and Gaussian Process (GP) extrapolation across H_2, LiH, and BeH_2 under depolarizing, amplitude damping, and coherent over-rotation noise. Our results demonstrate that noise is non-uniform and partially coupled across layers, and that layer-resolved ZNE with higher-order extrapolation can improve accuracy and variance under realistic NISQ noise models. These findings provide geometric insight into noise propagation in variational circuits and motivate targeted, layer-specific error mitigation strategies.
Standard Zero-Noise Extrapolation (ZNE) in Variational Quantum Eigensolvers (VQE) assumes a single global noise scaling parameter, failing to capture heterogeneous and non-linear noise propagation across layered quantum circuits. We simulate VQE parameter optimisation at a challenging L=6 hardware-efficient depth, extracting the exact expectation values at each iteration. When the optimal parameters theta_star are found, they are fixed, and the multi-parameter noise surface is mapped. We propose a multi-parameter noise framework, modeling expectation values as a function of layer-wise noise scaling factors E(lambda_1, lambda_2, ..., lambda_L). Using structured unitary folding U_l = U_l (U_l^dagger U_l)^((lambda_l - 1) / 2), we independently scale the noise contribution of each ansatz layer and empirically map the resulting multi-dimensional noise surface. We analyze the separability of inter-layer noise interactions, identify layers with disproportionate error contributions via the gradient dE/dlambda_l, and compare scalar ZNE with multivariate polynomial regression and Gaussian Process (GP) extrapolation across H_2, LiH, and BeH_2 under depolarizing, amplitude damping, and coherent over-rotation noise. Our results demonstrate that noise is non-uniform and partially coupled across layers, and that layer-resolved ZNE with higher-order extrapolation can improve accuracy and variance under realistic NISQ noise models. These findings provide geometric insight into noise propagation in variational circuits and motivate targeted, layer-specific error mitigation strategies.
Variational quantum circuits (VQCs) are central to near-term quantum computing, yet their practical deployment is severely hindered by noise. While existing error mitigation methods, such as zero-noise extrapolation (ZNE), typically assume static noise, real noisy intermediate-scale quantum (NISQ) systems exhibit dynamic, time-varying noise that remains largely unaddressed. To overcome this critical gap, our work introduces a novel adaptive noise mitigation framework for VQCs that integrates ZNE with contextual multi-armed bandits (CMAB), enabling dynamic, context-aware selection of circuit-folding levels based on ansatz parameters (e.g., depth, parameter count) and the evolving noise environment. Unlike fixed-fold or heuristic ZNE, our approach uses online adaptation to improve the accuracy of ZNE and reduce redundant quantum circuit executions. Our extensive simulations and experiments on real quantum hardware reveal the following important properties: (i) deeper VQCs accumulate noise, degrading accuracy and increasing the number of quantum circuit executions; (ii) ZNE restores estimator fidelity when the folding level is chosen appropriately; and (iii) CMAB-guided folding cuts quantum circuit execution round trips by up to 40\%, bytes exchanged by up to 35\%, and end-to-end cost by up to 30\% under a 10~Mbps budget, with up to 6.9\% higher estimator fidelity (CIFAR-10, depth 3, noise band η=0.05), versus fixed-fold and grid-search ZNE. These results demonstrate substantial performance gains over existing noise mitigation methods, underscoring the effectiveness of our design in supporting robust noise mitigation for VQCs. The source code is also publicly released to support reproducibility.
Near term quantum processors operate in a noise dominated regime, motivating error mitigation techniques that recover accurate expectation values without full fault tolerance. Zero Noise Extrapolation (ZNE) is a widely used but biased error mitigation method that lacks rigorous error bounds. Its effective application requires nontrivial technical choices, most notably the selection of noise scaling factors and extrapolation models, making ZNE sensitive to user expertise and often necessitating costly trial and error procedures. Here, we introduce Folding Free Zero Noise Extrapolation (FF-ZNE), a method that removes the need for noise factor selection by achieving effective noise amplification without circuit folding. FF-ZNE exploits isomorphic hardware layouts with distinct native noise profiles, such that executing a fixed circuit across these layouts induces controllable variations in the effective noise strength. Under a depolarizing noise model, we analytically show that the resulting extrapolation admits a fixed linear form, eliminating extrapolator choice and enabling a seamless, user independent mitigation procedure. We further propose two algorithms that identify sets of isomorphic hardware layouts on which a given circuit yields sufficiently distinct expectation values to enable reliable zero noise extrapolation. Experiments on a 133 qubit IBM Quantum device demonstrate that FF-ZNE yields mitigated expectation values with average deviations of ~6% and 4.5% for up to 50 qubit EfficientSU2 (sparse) and Hamiltonian simulation (dense) circuits, respectively. The method is thus scalable and applicable to a broad range of circuits. By eliminating noise factor and extrapolator selection, FF-ZNE transforms zero noise extrapolation from a technique requiring expert tuning into a practical, scalable, and broadly accessible error mitigation method for current quantum hardware.
Increasing the utility of currently available Noisy Intermediate-Scale Quantum (NISQ) devices requires developing efficient methods to mitigate hardware errors. In this work we propose a novel Cyclic Layout Permutations-based Zero-Noise Extrapolation (CLP-ZNE) protocol for such a task. The method leverages the inherent non-uniformity of gate errors in NISQ hardware to extrapolate the expectation value, averaged over cyclic circuit layout permutations, to the level of zero noise. In contrast to the previous layout permutation based approaches, for an n-qubit circuit CLP-ZNE requires execution of only O(n) and at most O(n2) different circuit layouts for circuits of one-dimensional and arbitrary connectivity, respectively. When benchmarked against noise channels modeling the IBM Torino quantum computer, the method reduces a typical error in expectation values of n=12 qubit circuits by an order of magnitude, outperforming standard unitary folding ZNE. By demonstrating the ability to mitigate noise of real hardware specifications, including both depolarizing and T1/T2 relaxation processes, these results give evidence for the applicability of CLP-ZNE to present-day NISQ processors.
Variational quantum circuits (VQCs) solving partial differential equations (PDEs) on near-term quantum hardware face a critical challenge: hardware noise degrades solution fidelity and disrupts convergence. We present a systematic study of three noise channels; depolarizing, amplitude damping, and bit-flip on VQCs constrained by PDE residual loss functions for the heat equation, Burgers' equation, and the Saint-Venant shallow water equations. We benchmark three error mitigation strategies: zero-noise extrapolation (ZNE) via Richardson polynomial fitting, probabilistic error cancellation (PEC), and measurement error mitigation through inverse confusion matrices. Our numerical experiments on 6-qubit, 4-layer circuits demonstrate that ZNE reduces absolute error by 82-96% at low noise (p = 0.001), with effectiveness degrading gracefully at higher noise strengths. We prove analytically and confirm numerically that physics-constrained circuits exhibit inherent noise resilience: at p = 0.01, constrained circuits maintain 25-47% higher fidelity than unconstrained counterparts, with the advantage scaling with PDE complexity. PEC provides near-exact correction at low gate counts but incurs exponential sampling overhead, rendering it impractical beyond ~60 gates at p >= 0.02. Error budget decomposition reveals that systematic errors dominate at all noise levels (43-58%), while the PDE residual component grows from ~10% to ~31% as noise increases, indicating that physics constraints absorb noise through structured gradient information. These results establish practical guidelines for deploying variational PDE solvers on NISQ hardware.
In the emergent realm of quantum computing, the Variational Quantum Eigensolver (VQE) stands out as a promising algorithm for solving complex quantum problems, especially in the noisy intermediate-scale quantum (NISQ) era. However, the ubiquitous presence of noise in quantum devices often limits the accuracy and reliability of VQE outcomes. This research introduces a novel approach to ameliorate this challenge by utilizing neural networks for zero noise extrapolation (ZNE) in VQE computations. By employing the Qiskit framework, we crafted parameterized quantum circuits using the RY-RZ ansatz and examined their behavior under varying levels of depolarizing noise. Our investigations spanned from determining the expectation values of a Hamiltonian, defined as a tensor product of Z operators, under different noise intensities to extracting the ground state energy. To bridge the observed outcomes under noise with the ideal noise-free scenario, we trained a Feed Forward Neural Network on the error probabilities and their associated expectation values. Remarkably, our model proficiently predicted the VQE outcome under hypothetical noise-free conditions. By juxtaposing the simulation results with real quantum device executions, we unveiled the discrepancies induced by noise and showcased the efficacy of our neural network-based ZNE technique in rectifying them. This integrative approach not only paves the way for enhanced accuracy in VQE computations on NISQ devices but also underlines the immense potential of hybrid quantum-classical paradigms in circumventing the challenges posed by quantum noise. Through this research, we envision a future where quantum algorithms can be reliably executed on noisy devices, bringing us one step closer to realizing the full potential of quantum computing.
Variational Quantum Eigensolvers (VQE) promise molecular ground-state energies on today's noisy intermediate-scale quantum (NISQ) processors, but device noise biases the estimated energy severely — under a device-calibrated noise model, the hydrogen molecule's energy error grows from 0.000 mHa (noiseless) to 303.6 mHa (noisy), roughly 190× the "chemical accuracy" threshold of 1.6 mHa that computational chemistry requires. Error-mitigation techniques repair such biases in software, but published results usually report each technique in isolation, making it impossible to know which mitigation to buy with a fixed shot budget. This work answers that question with a controlled comparison. Under identical circuits, noise profiles and shot budgets, I measure the bias and variance of four estimator stacks — raw sampling, twirled-readout extinction (TREX-style calibrated readout inversion), zero-noise extrapolation (ZNE), and ZNE+TREX — across independent random seeds. Three findings emerge. (1) ZNE is a bias–variance tradeoff, not a free lunch: a 7-point Richardson extrapolant reduces the deterministic bias 3200-fold (303.6 → 0.094 mHa) but amplifies statistical noise by a measured factor of up to 25× per run, while TREX removes readout bias with no variance penalty. (2) ZNE has a finite operating window in circuit depth: error recovery falls 99.97% → 99.1% → 95.5% as CX count grows 56 → 112 → 168, and is exhausted entirely for a 1616-CX lithium-hydride circuit at near-term error rates. (3) A noise-bias-tailored repetition code corrects the dominant error axis with logical error rates matching theory (3p², 10p³, 35p⁴ for distances 3, 5, 7) at strictly linear gate overhead (gates = 6d − 6). The results reframe mitigation selection as budget allocation on an empirically measured bias–variance frontier and provide open-source tooling to reproduce every number.