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International Conference on Artificial Intelligence and Signal Processing (AISP)

A Deep Learning Driven Quantum Hybrid Approach for Early Breast Cancer Detection

Pallakonda Siri, G. Anitha, Maddukuri Reshma Naga Venkata Durga

Published Nov 22, 2025• 1 citation
Publisher

Abstract

Breast cancer is also the most diagnosed cancer in women worldwide, and over 2.3 million new cases are annually reported. Early detection is crucial for successful treatment and better survival. In this work, we present a new hybrid model which employs CNN with QML to achieve better classification in breast US images. To address this issue, we work with the publicly available BUSI Dataset from Kaggle that consists of 780 grayscale ultrasound images of benign, malignant, and normal categories, and existing which is widely used by the community and contains normal, benign and malignant samples, and develop a hybrid model based on a classical CNN feature extractor followed by a four-qubit Parametrized Quantum Circuit (PQC), with PennyLane and IBM Q, for prediction and classification of classes after visual and statistical exploratory analysis that evidences an important class imbalance in the data and non-linear feature separability, for which the hybrid architecture performs statistically significantly better. The model achieves accuracy of 95.4%, which is superior to that of the classical CNN baselines. This study demonstrates the potential of QML in medical imaging and early cancer detection

DOI
10.1109/aisp68263.2025.11396250

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Breast cancer is also the most diagnosed cancer in women worldwide, and over 2.3 million new cases are annually reported. Early detection is crucial for successful treatment and better survival. In this work, we present a new hybrid model which employs CNN with QML to achieve better classification in breast US images. To address this issue, we work with the publicly available BUSI Dataset from Kaggle that consists of 780 grayscale ultrasound images of benign, malignant, and normal categories, and existing which is widely used by the community and contains normal, benign and malignant samples, and develop a hybrid model based on a classical CNN feature extractor followed by a four-qubit Parametrized Quantum Circuit (PQC), with PennyLane and IBM Q, for prediction and classification of classes after visual and statistical exploratory analysis that evidences an important class imbalance in the data and non-linear feature separability, for which the hybrid architecture performs statistically significantly better. The model achieves accuracy of 95.4%, which is superior to that of the classical CNN baselines. This study demonstrates the potential of QML in medical imaging and early cancer detection
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Abstract The breast cancer is widely prevalent, with millions of new cases and deaths reported annually. Globally, one in every 70 women is affected with breast cancer. It is apparent from the statistics that the number of breast cancer subjects are exponentially rising day by day. Early detection of the disease plays a crucial role to decrease the mortality rate and increase the survival chance. Quantum machine learning is an upcoming field in the era of big data, which helps to process the complex data more efficiently. This study aims to explore the QML models to accurately predict the breast cancer subjects and diagnose the disease in the early stage. Additionally, QML-based models aid in the classification of breast cancer as either benign or malignant. This study presents the comparative analysis of three QML models, namely QRF, QkNN and QSVM, for breast cancer classification using the Breast Cancer Wisconsin dataset. Each model is evaluated based on key performance metrics and the models achieved the accuracy of 97%, 94% and 90%, respectively. Hence, the results showed that the QRF outperformed QSVM and QkNN in classification accuracy, demonstrating superior ability to distinguish between malignant and benign tumors. This study highlights the potential of QML in medical diagnostics while emphasizing the need for further research in hybrid quantum-classical approaches, improved feature mapping techniques, and optimized quantum circuits.
Breast cancer is one among the most common diseases that are encountered in the world and one of the principal causes of death among women, early detection being crucial to enhance survival rates but mammograms are an important tool that can save lives by finding breast cancer at its earliest stages but the manual evaluation is dependent on a radiologist's clear interpretation and analysis of which sometimes erroneously or misses the key findings. This research work deals with breast cancer detection from mammogram images and hence provides a solution for the issues identified by training Quantum Convolutional Neural Network (Quantum CNN). Quantum CNNs is recently being integrated with classical deep learning models in the form of Quantum CNN where quantum mechanical properties are used to support feature extraction and data handling. This research work trains the Quantum CNN using publicly available datasets, including the CBIS-DDSM Breast Cancer Image Dataset and the Breast Histopathology Images dataset. Key methods used include data preprocessing techniques such as Region of Interest (ROI) extraction, morphological operations, and quantum-enhanced convolutional layers for image classification. The proposed model demonstrates improved accuracy and computational efficiency over classical CNNs, making it a promising tool for more accurate and faster breast cancer detection.
This paper explores the potential of quantum ma-chine learning for breast cancer detection. We designed a binary classification approach using the BreastMNIST dataset and segmented mass regions derived from the BCDR dataset. A quanvolutional layer is employed as a quantum feature extractor, interfaced with elements of classical neural networks, to enhance the detection of malignant and benign patterns in breast tissue. The hybrid quanvolutional neural network aims to mitigate challenges associated with traditional machine learning models, such as feature sparsity and data imbalance. This architecture employs a simple yet efficient design that integrates the strengths of both quantum computing and classical methods, reducing computational complexity while maintaining performance. Re-sults demonstrate the potential of quanvolutions in diagnostic accuracy, offering a promising framework for integrating quan-tum computing in medical imaging. This approach provides an optimized solution that balances quantum processing with classical systems for more effective and scalable applications.