Quantum Artificial Intelligence (QAI) has emerged at the nexus of quantum computing and AI, promising to redefine computational frontiers. This survey critically synthesizes the state-of-the- art through 2024, elucidating the profound bidirectional synergy between these fields. We analyze how classical machine learning is accelerating quantum hardware control, circuit optimization, and error correction. Conversely, we assess the potential quantum advantage of algorithms, including variational and kernel-based methods, across domains such as drug discovery, financial modeling, and cybersecurity. Our analysis reveals a critical trade-of between the utility of near-term Noisy Intermediate-Scale Quantum (NISQ) devices and the long-term promise of fault-tolerant architectures. We identify fundamental obstacles to QAI’s advancement, including hardware decoherence, algorithmic barren plateaus, and data-encoding bottlenecks. While QAI’s potential is transformative, achieving practical quantum advantage requires a concerted effort to overcome these core challenges at the hardware-software interface. This work provides a roadmap for navigating the current landscape and prioritizing future research in this rapidly evolving discipline. • We introduce a bi-directional Quantum-AI framework, AI-for-QC and QC-for-AI, and provide a practical roadmap for integrating both paradigms across the full stack. • We quantify AI-enabled gains: calibration time drops from 8 hours to 2 hours, circuit depth falls by up to 42%, and ML decoders cut logical error rates by about half. • We synthesize comparative guidance on VQAs, quantum kernels, and hybrid/quantum Transformers, clarifying trainability limits and criteria for credible quantum advantage. • We deliver a clinically grounded playbook for radiology, covering small-data use cases, plug-in hybrid modules, OOD validation, fairness assessments, and TRIPOD/CONSORT-AI reporting.
Quantum Artificial Intelligence (QAI) has emerged at the nexus of quantum computing and AI, promising to redefine computational frontiers. This survey critically synthesizes the state-of-the- art through 2024, elucidating the profound bidirectional synergy between these fields. We analyze how classical machine learning is accelerating quantum hardware control, circuit optimization, and error correction. Conversely, we assess the potential quantum advantage of algorithms, including variational and kernel-based methods, across domains such as drug discovery, financial modeling, and cybersecurity. Our analysis reveals a critical trade-of between the utility of near-term Noisy Intermediate-Scale Quantum (NISQ) devices and the long-term promise of fault-tolerant architectures. We identify fundamental obstacles to QAI’s advancement, including hardware decoherence, algorithmic barren plateaus, and data-encoding bottlenecks. While QAI’s potential is transformative, achieving practical quantum advantage requires a concerted effort to overcome these core challenges at the hardware-software interface. This work provides a roadmap for navigating the current landscape and prioritizing future research in this rapidly evolving discipline. • We introduce a bi-directional Quantum-AI framework, AI-for-QC and QC-for-AI, and provide a practical roadmap for integrating both paradigms across the full stack. • We quantify AI-enabled gains: calibration time drops from 8 hours to 2 hours, circuit depth falls by up to 42%, and ML decoders cut logical error rates by about half. • We synthesize comparative guidance on VQAs, quantum kernels, and hybrid/quantum Transformers, clarifying trainability limits and criteria for credible quantum advantage. • We deliver a clinically grounded playbook for radiology, covering small-data use cases, plug-in hybrid modules, OOD validation, fairness assessments, and TRIPOD/CONSORT-AI reporting.
The synergistic integration of quantum computational paradigms with artificial intelligence frameworks represents one of the most transformative technological frontiers of this decade. This comprehensive review provides a detailed technical examination of quantum artificial intelligence (QAI) from foundational principles to contemporary implementations. We systematically analyze the architectural frameworks of quantum machine learning systems, including quantum neural networks, variational quantum algorithms, and quantum-enhanced optimization methods. The paper presents a critical assessment of implementation challenges within the Noisy Intermediate-Scale Quantum (NISQ) computing paradigm, addressing decoherence effects, error mitigation methodologies, and the barren plateaus phenomenon. Through rigorous analysis of current literature and experimental implementations, we evaluate promising application domains including quantum chemistry, financial modeling, and materials science. The review concludes with a strategic roadmap for achieving practical quantum advantage in artificial intelligence applications, highlighting emerging research directions and hardware development trajectories.
Artificial Intelligence (AI) continues to drive innovation across industries, but faces mounting challenges in computational scalability, optimization, and interpretability as models grow increasingly complex. Quantum Artificial Intelligence (QAI) offers a promising path forward by leveraging quantum phenomena such as superposition and entanglement to augment learning processes beyond classical limits. This review synthesizes the recent progress in QAI, emphasizing a comparative perspective framed through its advantages and limitations. It examines how hybrid quantum-classical architectures and variational models seek to address constraints in the Noisy Intermediate-Scale Quantum (NISQ) era, and how applications in healthcare, finance, and cybersecurity illustrate both the potential and the barriers of the field. While several studies have broadly mapped the growth of QAI in algorithms and applications, this paper adopts a different perspective: emphasizing comparative analysis through advantages and limitations. The focus is on where QAI offers unique opportunities, where it encounters obstacles distinct from classical AI and quantum computing, and what research directions may transform these challenges into breakthroughs. By situating QAI within this comparative framework, the paper provides a realistic yet forward-looking assessment of its trajectory as a paradigm poised to reshape computational intelligence.
Objective: To synthesize the state of the art on how quantum computing (QC) and artificial intelligence (AI) intersect, including algorithmic foundations, software/hardware stacks, empirical evidence of advantage, applications, and open challenges. Methods: We executed a structured search (2019 – 20th August 2025) across major journals (Nature portfolio, APS/PR, Elsevier), arXiv, and official framework documentation (Qiskit, Cirq/TFQ, PennyLane; AWS Braket; NVIDIA CUDA-Q). We included peer‑reviewed studies, comprehensive surveys, and official docs; we excluded opinion pieces and non-reproducible claims. Results: The field converges on hybrid quantum‑classical workflows with two dominant AI families: (i) quantum kernel methods and (ii) variational circuits/QNNs. Trainability remains a core challenge (barren plateaus and noise), with mitigation strategies advancing (local costs, layerwise training, engineered dissipation, learned decoders). Frameworks and cloud orchestrators now support end‑to‑end hybrid training. Empirical “utility” demonstrations in physics‑inspired tasks exist, while domain‑level advantage in mainstream ML is unproven and data‑dependent. Conclusions: QC‑AI integration is maturing into reproducible hybrid stacks. Near‑term value lies in quantum kernels with tailored feature maps, physics‑regularized QNNs, simulator‑accelerated pipelines, and AI‑for‑QC (calibration/decoding). Broad ML advantage awaits lower‑noise hardware and quantum‑friendly data embeddings.
The integration of quantum computing and artificial intelligence (AI) constitutes a bidirectional synergy that is reshaping both disciplines. This review investigates the reciprocal relationship in which AI addresses foundational challenges in quantum computing, while quantum computing offers the potential to advance machine learning beyond classical constraints. Recent advancements exemplify this interaction: Google DeepMind’s AlphaQubit neural network decoder has achieved state-of-the-art quantum error correction, improving performance by 6% over tensor networks and 30% over correlated matching methods. Additionally, quantum neural networks have demonstrated exponential improvements in sample complexity for specific learning tasks. This review systematically examines the current landscape of quantum-AI integration across three primary dimensions. First, it addresses AI-enhanced quantum systems, such as transformer-based error correction, reinforcement learning for circuit optimization, and AI-driven hardware calibration. Second, it explores quantum-accelerated machine learning algorithms, including variational quantum neural networks, quantum generative adversarial networks, and quantum reinforcement learning. Third, it evaluates industry deployments in sectors such as life sciences, financial services, climate modeling, and pharmaceutical development. Notable examples include IonQ’s quantum chemistry simulations, which achieved 40% efficiency improvements in carbon capture material design; St. Jude’s identification of KRAS protein inhibitors using quantum machine learning with experimental validation; and JP Morgan Chase’s implementation of quantum portfolio optimization. The analysis indicates that the field has advanced from preliminary demonstrations to production-grade applications, especially in drug discovery and molecular simulation, where quantum computing offers measurable benefits. Nevertheless, several challenges remain, including barren plateaus in variational algorithms, scalability constraints in current noisy intermediate-scale quantum (NISQ) devices, requirements for real-time decoding speed, and the necessity for fault-tolerant quantum computing (FTQC) systems. IBM’s 2029 roadmap, which targets 200 logical qubits capable of executing 100 million gates, together with progress in high-rate quantum low-density parity-check codes, outlines a trajectory toward practical fault tolerance. This review makes two principal research contributions: Comprehensive Evaluation Framework for Quantum Advantage Assessment: We establish the first systematic, integrated methodology for determining quantum computing feasibility that combines problem characterization, resource estimation, quantum advantage assessment, and quantum algorithm paradigm selection. This framework consolidates criteria scattered across academic literature and industry practice into a unified decision-making tool applicable across chemistry, optimization, machine learning, and simulation domains. The framework addresses a critical industry need: enabling non-expert practitioners (chemists, financial analysts, materials scientists) to objectively assess quantum computing suitability without requiring deep quantum expertise. Novel Quantum Resource Optimization Algorithms: We present three concrete algorithmic contributions advancing quantum-AI integration: • Data Encoding Efficiency Algorithm that automatically selects optimal qubit encoding strategies (amplitude vs. angle encoding) minimizing total quantum resource consumption • Error Budget Optimization Algorithm that iteratively determines optimal quantum error correction code distance balancing logical error rate targets against physical qubit overhead • Real-time Hardware Specification Aggregation from multiple quantum cloud platforms (IBM Quantum, Amazon Braket, Google, IonQ) enabling dynamic feasibility assessment as hardware capabilities evolve Combined, these contributions establish quantum computing advantage assessment as a rigorous, data-driven discipline rather than ad-hoc expert judgment. The framework enables strategic quantum computing investment decisions, accelerates problem identification for early quantum utility, and provides a reference methodology for standardizing quantum advantage evaluation across academia and industry. This review synthesizes insights from recent academic literature, industry implementations, and expert perspectives to deliver a comprehensive assessment of quantum-AI synergies grounded in this evaluation framework. The mathematical foundations, ranging from quantum Fourier transforms to Gaussian processes, are examined. Best practices for researchers and practitioners are also outlined. The findings suggest that, although universal quantum advantage has not yet been realized, domain-specific quantum-AI applications in chemistry, optimization, and sensing are achieving practical utility in 2024-2025. This development marks a significant transition from theoretical potential to commercial realization, informed by rigorous evaluation methodologies.
Quantum computing and artificial intelligence (AI) are two rapidly evolving technologies poised to redefine the future of computation and decision-making.The two fields unite under the name Quantum Artificial Intelligence (QAI) or Quantum Intelligence, which enables a transformative approach to problem-solving through the fusion of AI mental functions with quantum computing capabilities.This paper provides a comprehensive review of the current landscape, highlighting the opportunities and challenges in integrating quantum computing with AI systems.The research investigates current developments in quantum machine learning, quantum neural networks, and hybrid quantum-classical systems, which show promise for achieving rapid performance improvements and enhanced scalability and data processing capabilities.At the same time, it identifies critical barriers, including hardware limitations, algorithmic complexity, data encoding issues, and the lack of standardization in frameworks.The review further explores future directions, including the role of explainable AI, error correction, and interdisciplinary research in achieving practical quantum-AI synergy.By analyzing both the technological potential and the practical constraints, this paper aims to outline a roadmap for advancing quantum intelligence as a transformative force in next-generation computational paradigms.
The field of Quantum Artificial Intelligence (Quantum AI) has emerged as a promising interdisciplinary research area where the computational power of quantum computing is merged with the learning and decision-making power of AI. The application of quantum principles such as superposition, entanglement and quantum interference to machine learning algorithms has created new possibilities for solving problems that may be difficult to solve by classical machines. In the last few years, advances in Noisy Intermediate-Scale Quantum (NISQ) devices have helped to speed advances in Quantum Machine Learning (QML) algorithms, Quantum Neural Networks (QNNs), Quantum Support Vector Machines (QSVMs), Quantum Convolutional Neural Networks (QCNNs) and hybrid learning algorithms. This review provides a comprehensive overview of the research in the field of Quantum AI from 2020 to 2026, covering the key concepts, novel architectures, algorithmic advancements, and practical applications. A critical assessment of the application of Quantum AI in fields such as healthcare, finance, cybersecurity, scientific computing and optimization problems is provided, and the benefits of quantum-enhanced learning models are discussed. In addition, common difficulties such as quantum hardware limitations, sensitivity to noise, encoding of data, scalability constraints and a lack of speed in training variational quantum circuits are discussed. The review also covers new avenues of research, including trustworthy quantum machine learning, explainable Quantum AI, quantum federated learning, and fault-tolerant quantum computing. The results suggest while practical large-scale deployment is currently limited by existing hardware capabilities, hybrid quantum-classical systems have great potential to rapidly move intelligent data processing and develop next-generation AI systems.