Parkinson's disease (PD) is a progressive neuro-degenerative condition with an urgent need for timely and pinpoint diagnosis for adequate treatment. Despite potential for prediction with traditional machine learning techniques, PD data remains difficult to solve for traditional machine learning techniques due to the high computational complexity and the nature of data. We introduce in this work a Hybrid Quantum-Classical AI Framework that combines advantages of QC and provide benefits in predictive accuracy as well as computational efficiency for real time Parkinson's disease detection. We use classical deep learning models in conjunction with Variational Quantum Circuits (VQC) to perform efficient feature extraction and classification of biomedical signals: speech and its recordings, gait analysis, and EEG data. We evaluate the performance of our proposed framework against deep learning models that are standard and based on the accuracy, precision, recall and processing time. Our experimental results suggest that our hybrid quantum classical model outperforms classical methods for both accuracy and efficiency, demonstrating the potential of quantum machine learning (QML) in healthcare. This work gives a taste of the quantum revolution realized in medical diagnostics and paves the way for what could in the future be quantum enhanced disease prediction.
Parkinson's disease (PD) is a progressive neuro-degenerative condition with an urgent need for timely and pinpoint diagnosis for adequate treatment. Despite potential for prediction with traditional machine learning techniques, PD data remains difficult to solve for traditional machine learning techniques due to the high computational complexity and the nature of data. We introduce in this work a Hybrid Quantum-Classical AI Framework that combines advantages of QC and provide benefits in predictive accuracy as well as computational efficiency for real time Parkinson's disease detection. We use classical deep learning models in conjunction with Variational Quantum Circuits (VQC) to perform efficient feature extraction and classification of biomedical signals: speech and its recordings, gait analysis, and EEG data. We evaluate the performance of our proposed framework against deep learning models that are standard and based on the accuracy, precision, recall and processing time. Our experimental results suggest that our hybrid quantum classical model outperforms classical methods for both accuracy and efficiency, demonstrating the potential of quantum machine learning (QML) in healthcare. This work gives a taste of the quantum revolution realized in medical diagnostics and paves the way for what could in the future be quantum enhanced disease prediction.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting millions worldwide, where early and accurate diagnosis plays a critical role in improving patient outcomes. While classical machine learning methods have shown strong performance in PD classification using clinical and acoustic data, they remain limited in capturing complex nonlinear feature interactions in high-dimensional spaces. This study explores the application of quantum machine learning (QML) techniques for PD prediction, focusing on Variational Quantum Classifiers (VQC) and Quantum Support Vector Machines (QSVM), and compares their performance with strong classical baselines including Logistic Regression, SVM, Random Forest, Grid Search–optimized models, and XGBoost. Experiments were conducted using stratified train–test splits and validated through cross-validation and statistical testing. Results show that classical models achieve competitive performance, with XGBoost reaching 91.9% accuracy. However, quantum models demonstrate slightly improved performance, with the VQC using EfficientSU2 achieving the highest accuracy of 93.1%, followed by the Real Amplitudes VQC (92.6%) and QSVM (92.2%). These improvements are consistent across evaluation metrics including F1-score and recall. Statistical analysis using 10-fold cross-validation indicates that the VQC (EfficientSU2) shows a significant improvement over classical baselines ( p = 0.031), while other quantum models do not achieve statistical significance over XGBoost ( p > 0.05). McNemar’s test on the independent test set confirms no significant difference in final prediction distributions between quantum and classical models. Overall, the findings suggest that quantum machine learning models are competitive with state-of-the-art classical approaches, offering marginal but consistent performance gains. This study highlights the potential of quantum-enhanced learning frameworks for biomedical classification tasks, while also emphasizing that their advantages remain incremental rather than definitive under current simulation-based implementations.
The healthcare systems produce a tremendous volume of medical data which may be in the form of patient records, laboratory test results and diagnostic reports. It is quite necessary to analyze such data accurately and efficiently in order to detect diseases early and plan appropriate treatment . Conventional machine learning methods have a tendency to struggling with large-dimensional and complicated medical data. To address these shortcomings, this project suggests a hybrid Quantum Machine Learning (QML) scheme of analyzing medical data and diagnosing a disease. The suggested system combines the classical data preprocessing with the quantum-enhanced data learning algorithms including Variational Quantum Circuits (VQC) and Quantum Support Vector Machines (QSVM). Medical data is first processed by cleaning, normalizing and encoding to quantum states. Complex patterns and correlations that traditional algorithms can hardly be able to learn are then learned with the quantum model. The measures used to judge the performance are accuracy, precision, recall and F1-score. The results of the experimental process show that the model based on QML yields better diagnostic accuracy than the conventional machine learning. This is where there is great potential in real time medical decision support systems, with the future prediction of disease and the personalized solution of care. The suggested framework indicates the potential and benefits of switching to quantum computing methods in healthcare analytics.
Abstract Parkinson’s disease (PD) involves a slowly advancing neurological condition that profoundly impairs motor as well as cognitive abilities, making prompt and precise diagnosis essential for successful treatment. Diagnosing PD using MRI images is difficult because of subtle changes within the brain and imbalanced datasets. While existing methods such as traditional Machine Learning (ML) and Deep Learning (DL) have made progress, they often struggle to capture important features and effectively handle limited data . To resolve these concerns, this work suggests a combined approach starting with generating additional MRI images using a Deep Convolutional Generative Adversarial Network (DCGAN) to balance the dataset. The feature extraction from these images is performed using the InceptionV3 model. These features are then enhanced by a Pyramid Attention Network (PAN), which helps to concentrate on the data’s most pertinent sections. Finally, the enhanced features are classified using a Variational Quantum Classifier (VQC) with amplitude encoding, which leverages quantum-inspired ML techniques to improve classification performance. This pipeline achieved an overall accuracy of 82.04%, outperforming earlier models. The results demonstrate the feasibility of integrating quantum-inspired models within a hybrid framework for PD classification from MRI scans.
A novel technique in early Parkinson's disease diagnosis with the use of a quantum long short-term memory model is described in this paper. Quantum computing, therefore, coupled with deep learning, seeks to improve the accuracy as well as efficiency of classifying traditional LSTM models, which even becomes more critical in cases of neurodegenerative diseases like Parkinson's disease, where diagnostics at an early stage would be helpful. The model was tested heavily on public datasets and compared with traditional deep learning models, which were significantly outperformed by this model with its superior accuracy and precision and recall rates. Furthermore, the computation time hugely became lower and thus possibly may revolutionize diagnostic procedures. These innovations will eventually establish quantum machine learning in medicine at a more accurate and faster diagnosis pace. Future development will focus on expanding the quantum LSTM so it can be more generally applicable to various situations for other medical conditions. Researchers believe that the configuration of the quantum layers should be modified, and this model will be extended to other deep learning models to have a more comprehensive and versatile tool in diagnosis for Parkinson's disease and perhaps other medical uses. The ultimate vision in the long term would be to use quantum-based models, not only for early detection but also improvement in prediction and personalization of treatment to revolutionize health care and thereby improve patient outcomes with neurodegenerative diseases.
Parkinson's disease is a progressive neurological disorder.Speech, gait, and handwriting often change before a specialist can confirm the diagnosis.Clinics still depend heavily on observation, which takes time and can vary between doctors.Recent papers combine machine learning with quantum and hybrid quantum-classical models to improve screening from multimodal data.This review covers eight studies (2023-2026) that use Quantum LSTM, variational quantum circuits, quantum neural networks, quantum-inspired SVM, and metaheuristic feature selection for PD detection.We note which biomarkers each work uses, the accuracy or AUC reported, and repeated limits: simulation-only runs, public datasets, and weak clinical follow-up.A shared pipeline is summarised.Quantum AI may help earlier detection, but surveyed systems are not yet ready for routine hospital use without hardware noise tests and longer patient studies.
Abstract Neuro-imaging data is necessary for timely and correct diagnosis of the disease Alzheimer’s (AD). Early clinical intervention is challenging due to the high-dimensional nature of the images, making it computationally difficult to work on representations, sparse annotated datasets and inter-subject variance. Deep convolutional VGG, ResNet, DenseNet, MobileNet and other neural networks (CNNs) have shown good performance. Diagnostic performance, but they are based on a high number of parameters and require highly trained personnel. Data can often times restrict resilience to data-skimy clinical settings. To address these challenges, the current paper presents a hybrid Quantum Machine Learning (QML) architecture for Alzheimer’s disease Detection and classification based on a combination of classical CNN-based feature extraction and Variational quantum classifier. In the suggested method, diseased, relevant, and compact features are extracted using pre-trained CNN backbones. Data from structural MRI scans is later translated into quantum states and computed. With parameterised variational quantum circuits optimised with a hybrid quantum-classical learning loop. The proposed method has been experimentally evaluated on benchmark datasets of MRI scans of Alzheimer’s patients. The hybrid CNNQML model has a mean classification accuracy of about 93% which is similar to deep CNN models, including ResNet and DenseNet (94%), and much more. Beating lightweight models like MobileNet and shallow CNNs by six percentage points. It is worth noting that the hybrid QML model performs better in conditions with limited training data. Performance degradation is observed in accuracy and AUC for all CNN variants, with up to 5% lower performance to deep CNNs. Cross-validation, confidence interval, paired significance test, and statistical validation. Effect size analysis proves the fact that the hybrid model produces statistically significant performance, as well as cases of clinically meaningful improvements over lightweight CNN baselines. Similar to the state-of-the-art deep networks with significantly reduced trainable parameters in the classification stage. These findings show that hybrid QML is a data-efficient and powerful substitute in the diagnosis of Alzheimer’s. On the whole, this is a work that sets a practical way to integrate quantum machine learning into clinical neuro-imaging pipelines and hybrid settings. QML has supplementary deep-learning enhancement to classics in next-generation Alzheimer’s Decision-support systems.