We report a low-noise compensated tuned amplifier (cTAMP) architecture optimized for large-area photodiodes in stimulated Raman scattering (SRS) detection. By integrating a tunable RLC feedback network with a matching compensation inductor, the design simultaneously achieves resonance enhancement and amplifier stability despite the high junction capacitance of a 10 × 10 mm 2 photodiode. As a proof of concept, a detector configured for 20 MHz center frequency and 1 MHz bandwidth exhibits an output-referred noise floor of 31 nV / Hz , enabling shot-noise-limited linear operation from 0.1 mW up to 36 mW optical power under ∼50 μs time constant in the near-IR region. This wide dynamic range and low noise performance allow faithful characterization of high-power squeezed states that saturate conventional detectors, as verified in photon-number squeezing experiments. In addition, the detector facilitates biocompatible ultrafast SRS microscopy with milliwatt-level excitation, supporting hyperspectral live cell imaging without compromising sensitivity. These results establish the cTAMP-based detector as a versatile platform for high-sensitivity quantum optics and biomedical imaging, with potential for extension to other modulation-based optical measurements.
We report a low-noise compensated tuned amplifier (cTAMP) architecture optimized for large-area photodiodes in stimulated Raman scattering (SRS) detection. By integrating a tunable RLC feedback network with a matching compensation inductor, the design simultaneously achieves resonance enhancement and amplifier stability despite the high junction capacitance of a 10 × 10 mm 2 photodiode. As a proof of concept, a detector configured for 20 MHz center frequency and 1 MHz bandwidth exhibits an output-referred noise floor of 31 nV / Hz , enabling shot-noise-limited linear operation from 0.1 mW up to 36 mW optical power under ∼50 μs time constant in the near-IR region. This wide dynamic range and low noise performance allow faithful characterization of high-power squeezed states that saturate conventional detectors, as verified in photon-number squeezing experiments. In addition, the detector facilitates biocompatible ultrafast SRS microscopy with milliwatt-level excitation, supporting hyperspectral live cell imaging without compromising sensitivity. These results establish the cTAMP-based detector as a versatile platform for high-sensitivity quantum optics and biomedical imaging, with potential for extension to other modulation-based optical measurements.
Stimulated Raman scattering (SRS) microscopy is a powerful technique that allows for the visualization of molecular vibrational images for label-free imaging, metabolic imaging, and supermultiplex imaging. However, its sensitivity is mainly limited by the shot noise of laser pulses, and long acquisition times are sometimes required to detect weak SRS signals hidden by the shot noise. To overcome this limitation, quantum-enhanced (QE-) SRS microscopy has been demonstrated, while the low optical power of squeezed pulses limits the sensitivity. In this work, we present QE-SRS microscopy using quantum-enhanced balanced detection (QE-BD) scheme, where the sensitivity of balanced detection SRS microscope is enhanced by injecting squeezed vacuum, allowing for QE-SRS imaging with high power SRS pump pulses (typically several tens of milliwatt), while balanced detection causes 3 dB drawback in the signal-to-noise ratio. We experimentally demonstrate QE-SRS imaging with 2.6 dB noise reduction compared with shot-noise-limited balanced detection SRS. We also demonstrate hyperspectral QE-SRS imaging by fast wavelength tuning of Stokes pulses. These results show the potential feasibility of high-power QE-SRS whose sensitivity is beyond that of classical shot-noise-limited SRS microscopes.
Quantum-enhanced stimulated Raman scattering (QESRS) microscopy is expected to realize molecular vibrational imaging with sub-shot-noise sensitivity, so that weak signals buried in the laser shot noise can be uncovered. Nevertheless, the sensitivity of previous QESRS did not exceed that of state-of-the-art stimulated Raman scattering (SOA-SRS) microscopes mainly because of the low optical power (3 mW) of amplitude squeezed light [Nature594, 201 (2021)10.1038/s41586-021-03528-w]. Here, we present QESRS based on quantum-enhanced balanced detection (QE-BD). This method allows us to operate QESRS in a high-power regime (>30 mW) that is comparable to SOA-SRS microscopes, at the expense of 3 dB sensitivity drawback due to balanced detection. We demonstrate QESRS imaging with 2.89 dB noise reduction compared with classical balanced detection scheme. The present demonstration confirms that QESRS with QE-BD can work in the high-power regime, and paves the way for breaking the sensitivity of SOA-SRS microscopes.
The rapid development of coherent short-wavelength light sources in the extreme ultraviolet (EUV) and soft X-ray (SXR) regimes has created a growing need for advanced optoelectronic detection capabilities, particularly for quantum-noise-limited measurements, microelectronics and semiconductor metrology, and emerging quantum information applications. However, extending balanced photodetection to these wavelength regimes is severely hindered by a fundamental bandwidth-noise trade-off imposed by the exceptionally large junction capacitance of EUV-SXR silicon photodiodes. Here, we report a novel wideband photoreceiver architecture that overcomes this bottleneck via a bootstrapped transimpedance amplifier design. By leveraging a low-noise junction field-effect transistor interface, we effectively isolate the photodiode capacitance and suppress the apparent input capacitance seen by the core amplifier. Combined with active compensation of parasitic feedback reactance, this architecture mitigates the conventional trade-off between detector active area and signal bandwidth. Experimentally, we achieved a system-level input-referred noise floor of 13 fA/Hz, closely approaching theoretical thermal limits. Furthermore, we achieved a six-fold extension in signal-to-noise limited bandwidth and, through the implementation of a novel grounded field plate, demonstrated a common-mode rejection ratio (CMRR) exceeding 30 dB up to 100 kHz. This highly scalable, silicon-based architecture effectively bridges the short-wavelength detection gap, establishing a robust experimental platform for next-generation quantum-noise-limited and quantum-enhanced X-ray measurement, as well as ultra-sensitive inspection and metrology applications in high-numerical-aperture EUV lithography.
Stimulated Raman scattering (SRS) microscopy has emerged as a powerful technique for probing the spatiotemporal dynamics of molecular bonds with exceptional sensitivity, resolution, and speed. However, classically, its performance remains fundamentally constrained by optical shot noise, which imposes a strict limit on detection sensitivity and speed. Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents this barrier by harnessing amplitude-squeezed light. Specifically, we generate a Stokes beam with 5.2dB of amplitude squeezing using traveling-wave optical parametric amplification in second-order nonlinear waveguides, and combine it with a tunable coherent pump to access vibrational modes spanning from 1000 to 3100cm−1. Applied to quantum imaging of metabolites in biological tissue (pork muscle), our quantum-enhanced Raman microscope achieves an average noise suppression of 3.6dB and a 51% enhancement in signal-to-noise ratio (SNR) -- to the best of our knowledge, the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples.
Squeezed light has been applied in stimulated Raman scattering (SRS) spectroscopy [1] and microscopy [2] to break the shot-noise-limited sensitivity. The sub-shot-noise sensitivity achieved in quantum-enhanced SRS (QE-SRS) systems is advantageous for uncovering weak signals and achieving faster imaging speed, which attract the attention of biomedical scientists. To break the sensitivity of state-of-the-art SRS microscopes, the applied squeezed light power in QE-SRS systems should be high enough (>10mW). Recently, high-power picosecond-pulsed QE-SRS spectroscopy [3] based on balanced detection scheme [4] was reported, and a sensitivity that is comparable to state-of-the-art SRS microscopes was firstly demonstrated in QE-SRS microscopy based on the same scheme [5]. An important issue of QE-SRS based on balanced detection is the 3-dB additional noise, so >3-dB squeezing level is required to demonstrate an absolute sensitivity improvement compared with state-of-the-art SRS microscopes in single-photodiode detection scheme. However, it's hard to generate highly squeezed pulsed light because of the difficulty in temporal and spatial mode matching between squeezed vacuum (SQV) and local oscillator (LO). Here, we introduce QE-SRS in dual-polarization scheme, which can be implemented in high-power regime but is free from the 3-dB signal-to-noise ratio drawback.
Quantum-enhanced stimulated Raman scattering (QE-SRS) becomes a powerful method for high-sensitivity molecular vibrational spectroscopy and imaging by breaking the shot-noise-limited sensitivity of classical SRS. However, it’s still challenging to achieve quantum-enhancement with typical pulse power (<10-mW) for SRS. Although amplitude-squeezing technique was utilized in the previous QE-SRS, it limits the available optical power by its deamplification or optical loss at asymmetric beamsplitter. To circumvent this problem, we propose and demonstrate SRS spectroscopy with quantum-enhanced balanced detection (QE-BD) scheme, where squeezed vacuum (SQV) is combined with a strong local oscillator (LO) to enhance the sensitivity of SRS. We generated SQV at the central wavelength of 844-nm, using a periodically-poled stoichiometric LiTaO3 waveguide. Picosecond LO light is modulated by a spatial light modulator to achieve spatial matching with SQV , and resultant high squeezing level. At each photodiode, LO has ~10-mW optical power, and –3.1-dB squeezing level was observed. To obtain the QE-SRS spectrum of dimethyl sulfoxide-d6 (d-DMSO), we scanned the wavelength of Stokes laser by a high-speed spectral scanner composed of a grating and galvanometric scanner . The QE-SRS spectrum in the wavenumber range of 1950-2300-cm-1 was acquired with 2.1-dB signal-to-noise ratio (SNR) improvement compared with classical shot-noise-limited SRS under balanced-detection. The proposed QE-BD SRS paves the way for QE-SRS with high-power pulses, and shows a potential to exceed the SNR of state-of-the-art classical SRS system without quantum enhancement