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Micro and Nano Engineering

Scalability analysis for transmon-based quantum computers

Shi‐Li Zhang

Published Oct 15, 2025• 2 citations
Publisher

Abstract

Quantum computing has been envisioned to offer unprecedented advantages over conventional supercomputers in certain computational applications such as drug discovery and materials design. Despite of the tremendous developments in recent years, concerns about building a practical quantum computer persist. This Letter examines, from engineering viewpoint, the grand challenges to building such a machine based on the leading technology platform “transmon”. The examination leads to proposal of technological solutions to break the scalability barriers that originate from the physics behind the transmon design, thereby to enable giga-scale integration necessary for the promised applications.

DOI
10.1016/j.mne.2025.100327

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Quantum computing has been envisioned to offer unprecedented advantages over conventional supercomputers in certain computational applications such as drug discovery and materials design. Despite of the tremendous developments in recent years, concerns about building a practical quantum computer persist. This Letter examines, from engineering viewpoint, the grand challenges to building such a machine based on the leading technology platform “transmon”. The examination leads to proposal of technological solutions to break the scalability barriers that originate from the physics behind the transmon design, thereby to enable giga-scale integration necessary for the promised applications.
In the span of four decades, quantum computation has evolved from an intellectual curiosity to a potentially realizable technology. Today, small-scale demonstrations have become possible for quantum algorithmic primitives on hundreds of physical qubits. Nevertheless, there are significant outstanding challenges in quantum hardware, fabrication, software architecture, and algorithms on the path towards a full-stack scalable quantum computing technology. Here, we provide a comprehensive review of these scaling challenges. We show how to facilitate scaling by adopting existing semiconductor technology to build much higher-quality qubits, employing systems engineering approaches, and performing distributed heterogeneous quantum-classical computing. We provide a detailed resource and sensitivity analysis for quantum applications on surface-code error-corrected quantum computers given current, target, and desired hardware specifications based on superconducting qubits, accounting for a realistic distribution of errors. We provide comprehensive resource estimates for several utility-scale applications including quantum chemistry calculations, catalyst design, NMR spectroscopy, and Fermi-Hubbard simulation. We show that orders of magnitude enhancement in performance could be obtained by a combination of hardware improvements and tight quantum-HPC integration. Furthermore, we introduce high-performance architectures for quantum-probabilistic computing with custom-designed accelerators to tackle today's industry-scale classical optimization, machine learning, and quantum simulation tasks in a cost-effective manner.
Quantum computing stands at the frontier of computational revolution, promising to transform our ability to solve problems that remain intractable for today's most powerful classical computers. This article explores the fundamental principles of quantum computing, where quantum mechanical phenomena such as superposition and entanglement enable unprecedented parallel processing capabilities. We examine why quantum computers have become a focal point of global research and development, with potential applications ranging from drug discovery and climate modeling to breaking current encryption standards and optimizing complex logistics. The text delves into the various approaches being pursued in quantum computer development, including superconducting circuits, trapped ions, and topological qubits, while addressing the significant challenges of maintaining quantum coherence and minimizing errors. By examining both the theoretical framework and practical implementation efforts, this article provides a comprehensive overview of quantum computing's current state, its transformative potential, and the roadmap toward achieving quantum supremacy.
Quantum computing has surfaced as a revolutionary idea with the potential to transform industries ranging from cryptography to drug discovery. However, alongside its promise, quantum computing faces formidable challenges, particularly in the realm of hardware development and scalability. One of the central challenges lies in the creation and scaling of dependable hardware infrastructure. At present, quantum computers can only manipulate a limited number of qubits for brief periods before succumbing to noise-induced disruptions. This constraint severely curtails their ability to execute complex computations and address real-world problems with efficiency. Furthermore, the relentless march towards miniaturization presents a significant hurdle. As transistors shrink in size, quantum effects increasingly interfere with their behavior, posing a barrier to further hardware miniaturization and scalability. Moreover, the quest to increase qubit counts stands as a pivotal milestone in advancing quantum computing capabilities. However, achieving higher qubit counts is fraught with challenges. These include the maintenance of qubit coherence and stability, the mitigation of unwanted inter-qubit interactions, and overcoming logistical hurdles in fabrication and control systems. Each of these challenges presents a significant roadblock on the path to realizing the full potential of quantum computing. Despite these formidable obstacles, researchers and scientists are actively engaged in the pursuit of solutions. Through innovative approaches and rigorous experimentation, they are striving to overcome the barriers impeding hardware development and scalability. By addressing these challenges, quantum computing stands poised to unlock unprecedented computational power and drive breakthroughs in fields ranging from optimization and machine learning to materials science and beyond. Thus, while the road ahead may be fraught with challenges, the transformative potential of quantum computing compels us to persevere in our quest to harness the power of the quantum realm.
This article provides a comprehensive technical examination of quantum computing systems based on qubit technology, exploring their revolutionary potential to transform computational capabilities beyond classical limitations. Beginning with an analysis of the fundamental quantum mechanical principles—superposition, entanglement, and quantum interference—the article elucidates how these phenomena enable exponential computational advantages for specific problem domains. Various physical implementations of qubits are evaluated, including superconducting circuits, trapped ions, photonic systems, and theoretical topological approaches, with each platform presenting unique advantages and engineering challenges. It extends to practical applications across cryptography, optimization, and artificial intelligence, where quantum computing promises transformative capabilities. However, significant obstacles remain, including decoherence, high error rates, scalability limitations, and the ongoing development of practical quantum algorithms. Despite these challenges, the quantum computing landscape is evolving toward a hybrid paradigm where quantum and classical resources work in concert, with specialized quantum processors likely to deliver commercial value in specific domains before universal quantum computers become a reality.
Quantum-centric supercomputing has the potential to revolutionize various fields by offering unprecedented computational power to tackle the world's most pressing problems. This research survey aims to provide a comprehensive understanding of the fundamentals of quantum computing, the current state of quantum-centric supercomputers, and their potential applications in solving global challenges. We explore the basic concepts underlying quantum computing, including qubits, superposition, entanglement, and quantum algorithms. Furthermore, we examine the existing and proposed architectures of quantum-centric supercomputers, as well as recent technological advancements and breakthroughs. The paper also discusses the application of these advanced computational systems in areas such as climate modeling, drug discovery, cryptography, and artificial intelligence. Finally, we address the future directions and opportunities for quantum-centric supercomputing, including technological advances, research collaborations, and policy and ethical considerations. Our findings underscore the transformative potential of quantum-centric supercomputing and the need for continued research and development to fully harness its capabilities for addressing the world's most critical problems.
Quantum computing isn't merely another step forward in technology; it represents a leap into an entirely new paradigm for understanding information. By harnessing the strange but powerful principles of quantum mechanics, quantum computers use qubits that can exist in multiple states at once, connect instantly through entanglement, and solve certain problems far faster than any classical machine. This paper explores the fundamentals of quantum computing, from its theoretical roots to the breakthroughs and setbacks shaping its present. We examine the engineering and scientific challenges - from fragile qubits to daunting scalability issues - and the immense promise they hold for fields like cryptography, artificial intelligence, drug discovery, and materials science. Finally, we consider the future impact of this technology, both its opportunities and its risks, and how it may redefine industries, research methods, and even our approach to solving humanity's hardest problems. The purpose of this paper is to examine the fundamental principles, developmental trajectory, current challenges, and prospective impacts of quantum computing across scientific, industrial, and societal domains. Given its potential to reshape computational capabilities and address complex global challenges, this study holds significance for researchers, policymakers, and industry leaders seeking to understand and navigate the transition toward quantum technologies.