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Chinese Physics Letters

Super-Sensitive and Visibility-Enhanced Imaging with NOON States for Birefringent and Isotropic Samples

Shuang‐Yin Huang, Han-Bin 寒冰 Xi 席, Jing Gao, Jing Wang, Wen-Zheng Zhu, Hao Li, Chao Chen, Zhi‐Cheng Ren, Xi‐Lin Wang, Hui‐Tian Wang

Published Sep 29, 2025• 2 citations
Publisher

Abstract

Abstract As an emerging microscopic detection tool, quantum microscopes based on the principle of quantum precision measurement have attracted widespread attention in recent years. Compared with the imaging of classical light, quantum-enhanced imaging can achieve ultra-high resolution, ultra-sensitive detection, and anti-interference imaging. Here, we introduce a quantum-enhanced scanning microscope under illumination of an entangled NOON state in polarization. For the phase imager with NOON states, we propose a simple four-basis projection method to replace the four-step phase-shifting method. We have achieved the phase imaging of micrometer-sized birefringent samples and biological cell specimens, with sensitivity close to the Heisenberg limit. The visibility of transmittance-based imaging shows a great enhancement for NOON states. Besides, we also demonstrate that the scanning imaging with NOON states enables the spatial resolution enhancement of N compared with classical measurement. Our imaging method may provide some reference for the practical application of quantum imaging and is expected to promote the development of microscopic detection.

DOI
10.1088/0256-307x/42/10/100602

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Quantum techniques can be used to enhance the signal-to-noise ratio in optical imaging. Leveraging the latest advances in single-photon avalanche diode array cameras and multiphoton detection techniques, here, we introduce a supersensitive phase imager, which uses space-polarization hyperentanglement to operate over a large field of view without the need of scanning operation. We show quantum-enhanced imaging of birefringent and nonbirefringent phase samples over large areas, with sensitivity improvements over equivalent classical measurements carried out with equal number of photons. The potential applicability is demonstrated by imaging a biomedical protein microarray sample. Our technology is inherently scalable to high-resolution images and represents an essential step toward practical quantum-enhanced imaging.
Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.
Quantum-enhanced metrology techniques offer ultra-precise timekeeping, allowing for breakthroughs in navigation systems, global positioning, medical and Biological imaging. Quantum metrology, a core application of quantum technologies, leverages non-classical states of light (such as entanglement and squeezing) to enhance measurement precision, sensitivity, and resolution beyond the classical limits, particularly the shot-noise limit. Its application to bio imaging and microscopy offers significant advantages for studying delicate biological specimens, which are often susceptible to damage from the intense light typically required by conventional high-resolution methods. The abstract highlights the potential of quantum properties of light to revolutionize bio imaging by providing a non-invasive, highly sensitive, and high-resolution platform for observing biological processes at fundamental scales.
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