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ACS Photonics

Resolution in Two-Photon Imaging: A Local Manifestation of Entanglement

Thomas Gregory, Ermes Toninelli, Paul‐Antoine Moreau, Simon Peter Mekhail, Osian Wolley, K. Roberts, Jakub Bělín, Stephen Mark Barnett, Miles J. Padgett

Published Sep 27, 2025• 3 citations
Publisher

Abstract

High Resolution Image Download MS PowerPoint Slide The resolution of a classical imaging system is limited by diffraction. This limit can be overcome, for example, by implementing various forms of localization microscopy in which the center of a fluorescence distribution is estimated to an accuracy scaling with the square root of the number of detected photons, N . In quantum imaging the object can be illuminated using correlated photon-pairs, leading early work to suggest that a 2 improvement could be obtained as a result of averaging the position of N = 2 events. However, similar to quantum lithography, which relies upon quantum illumination using entangled photon-pairs and two-photon absorption, the minimum resolvable feature size is reduced by a factor of 2, not just 2 . Quantum imaging schemes can also lead to a factor of 2 improvement. By using a similar source of correlated photon-pairs to illuminate an object, a single-photon sensitive camera to detect the photon-pairs, and an image processing algorithm to record and sum the bisector positions of the transmitted photon-pairs, we realize a similar factor of ×2 improvement in image resolution, surpassing that of most earlier quantum imaging work.

DOI
10.1021/acsphotonics.5c01310

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High Resolution Image Download MS PowerPoint Slide The resolution of a classical imaging system is limited by diffraction. This limit can be overcome, for example, by implementing various forms of localization microscopy in which the center of a fluorescence distribution is estimated to an accuracy scaling with the square root of the number of detected photons, N . In quantum imaging the object can be illuminated using correlated photon-pairs, leading early work to suggest that a 2 improvement could be obtained as a result of averaging the position of N = 2 events. However, similar to quantum lithography, which relies upon quantum illumination using entangled photon-pairs and two-photon absorption, the minimum resolvable feature size is reduced by a factor of 2, not just 2 . Quantum imaging schemes can also lead to a factor of 2 improvement. By using a similar source of correlated photon-pairs to illuminate an object, a single-photon sensitive camera to detect the photon-pairs, and an image processing algorithm to record and sum the bisector positions of the transmitted photon-pairs, we realize a similar factor of ×2 improvement in image resolution, surpassing that of most earlier quantum imaging work.
We use entangled photons as the light source in a normal microscope. Using this quantum illumination improves both the resolution and noise rejection in the image. The resolution of any classical imaging system is limited by the diffraction created by the finite size of the imaging lens. By using a light source that emits pairs of entangled photons and carefully controlling a camera that is capable of detecting single photons it is possible to observe these photons arriving two-by-two. Applying camera analysis software to log only these two-by-two events one can form an image from the mid-point (bisector) of each of these pair events. The image formed from the sum of all these bisectors has an improved resolution that surpasses the classical limit. Another advantage of using a quantum illumination is that it allows the two-by-two events from entangled photon pairs to be distinguished from background (classical) light and sensor noise. When processed in this way the resulting image is free of camera noise and any background light may be eliminated. The use of a quantum illumination protocol such as that used here results in the elimination of background light and therefore allows the development of the optical equivalent of quantum radar – a quantum enhanced LIDAR scheme. Using quantum illumination, combined with commercially available cameras that are sensitive to single photons creates a new approach to super-resolution and low noise microscopy. Imaging through noise with quantum illumination, T Gregory, P-A Moreau, E Toninelli, and M J Padgett, Science Advances 6, eaay2652 (2020) Resolution-enhanced quantum imaging by centroid estimation of biphotons, E Toninelli, P-A Moreau, T Gregory, A Mihalyi, M Edgar, N Radwell, and M J Padgett, Optica 6, 347-353 (2019)
The spatial resolution of an optical system is limited by diffraction. Various schemes have been proposed to achieve resolution enhancement by employing either a scanning source/detector configuration or a two-photon response of the object. Here, we experimentally demonstrate a full-field resolution-enhancing scheme, based on the centroid estimation of spatially quantum-correlated biphotons. Our standard-quantum-limited scheme is able to image a general non-fluorescing object, using low-energy and low-intensity infrared illumination (i.e., with <0.001 photon per pixel per frame at 710 nm), achieving 41% of the theoretically available resolution enhancement. Images of real-world objects are shown for visual comparison, in which the classically bound resolution is surpassed using our technically straightforward quantum-imaging scheme.
Quantum imaging exploits the spatial correlations between photons to image object features with a higher resolution than a corresponding classical light source could achieve. Using a quantum correlated NNN-photon state, the method of optical centroid measurement (OCM) was shown to exhibit a resolution enhancement by improving the classical Rayleigh limit by a factor of 1/N1/N1/N. In this work, the theory of OCM is formulated within the framework of an imaging formalism and is implemented in an exemplary experiment by means of a conventional entangled photon pair source. The expected resolution enhancement of a factor of two is demonstrated. The here presented experiment allows for single-shot operation without scanning or iteration to reproduce the object in the image plane. Thereby, photon detection is performed with a newly developed integrated time-resolving detector array. Multi-photon interference effects responsible for the observed resolution enhancement are discussed and possible alternative implementation possibilities for higher photon number are proposed.
Quantum imaging exploits the spatial correlations between photons to image object features with a higher resolution than a corresponding classical light source could achieve. Using a quantum correlated N-photon state, the method of optical centroid measurement (OCM) was shown to exhibit a resolution enhancement by improving the classical Rayleigh limit by a factor of 1/N. In this work, the theory of OCM is formulated within the framework of an imaging formalism and is implemented in an exemplary experiment by means of a conventional entangled photon pair source. The expected resolution enhancement of a factor of two is demonstrated. The here presented experiment allows for single-shot operation without scanning or iteration to reproduce the object in the image plane. Thereby, photon detection is performed with a newly developed integrated time-resolving detector array. Multi-photon interference effects responsible for the observed resolution enhancement are discussed and possible alternative implementation possibilities for higher photon number are proposed.
Spatial resolution defines the fundamental limit of how precisely optical imaging systems can distinguish details within an object. Recent advances in quantum imaging have surpassed classical resolution limits by exploiting entanglement. However, experimental demonstrations of quantum enhancement above two times using entangled biphotons have thus far been limited to nonimaging experiments that use replication of the object or nonlinearity-both are impractical and inefficient. Here, without resorting to either, we enhance the classical resolution using entangled photon pairs by either two- or fourfold in two system configurations. While the signal photons traverse the object-containing arm only once, the idler photons traverse the symmetric object-free arm either once or thrice. These experiments demonstrate a scalable route toward quantum-correlated super-resolution imaging, motivate theoretical exploration of the underlying mechanisms, and open opportunities for high-precision, low-illumination microscopy.
Quantum imaging emerged quite recently as a breakthrough technology of overcoming the diffraction limit in microscopy and enhancement of optical resolution without the necessity to use hard radiation or perform scanning in the near field [1] , [2] . Both, the quantum imaging itself and the more “classical” techniques inspired by it (for example, super-resolution optical fluctuations imaging – SOFI [3] ), rely on detection and analysis of photon (intensity) correlations. Typically, it is believed that the more correlated illuminating light is used and the higher order of the correlations is measured, the larger super-resolution can be achieved. That conclusion is based on efficient narrowing of the point-spread function, which, however, does not necessarily imply better resolution as the ability to reconstruct smaller features of the investigated object successfully.