In this paper, we investigate how quantum computers can be effectively utilized as physical computational units, specifically within the limitations of Noisy Intermediate-Scale Quantum (NISQ) devices. A central question we address is: How can we effectively emulate macroscopic quantum dynamics within the constraints of NISQ devices to fully realize the computational advantages of quantum computing? To tackle this, we explore the design of a macroscopic physical model, using a particle beam model as a case study. By employing a data-centric approach to energy encoding, we aim to optimize quantum states and extract the Hamiltonian, facilitating the accurate simulation of complex physical systems. Our work demonstrates the potential of NISQ devices in advancing macroscopic physical simulations, despite their inherent noise and limited qubit numbers, offering a promising path toward achieving Quantum advantage.
In this paper, we investigate how quantum computers can be effectively utilized as physical computational units, specifically within the limitations of Noisy Intermediate-Scale Quantum (NISQ) devices. A central question we address is: How can we effectively emulate macroscopic quantum dynamics within the constraints of NISQ devices to fully realize the computational advantages of quantum computing? To tackle this, we explore the design of a macroscopic physical model, using a particle beam model as a case study. By employing a data-centric approach to energy encoding, we aim to optimize quantum states and extract the Hamiltonian, facilitating the accurate simulation of complex physical systems. Our work demonstrates the potential of NISQ devices in advancing macroscopic physical simulations, despite their inherent noise and limited qubit numbers, offering a promising path toward achieving Quantum advantage.
Quantum computing has emerged as a transformative paradigm capable of addressing computational challenges beyond the reach of classical systems.In the current era of Noisy Intermediate-Scale Quantum (NISQ) devices, practical quantum hardware is characterized by limited qubit counts, short coherence times, gate errors, and the absence of full error correction.Despite these constraints, significant progress has been made in developing quantum machine learning (QML) techniques tailored to operate on near-term quantum processors.This paper presents a comprehensive review of Quantum Machine Learning in the context of NISQ computing.We first outline the fundamental principles of quantum computing, including qubits, superposition, entanglement, and quantum parallelism, followed by a detailed discussion of the NISQ computing model and its hardware limitations.The review then examines hybrid quantum-classical learning frameworks, variational quantum algorithms, quantum data encoding strategies, and noise mitigation techniques that enable practical implementation on existing platforms.Emerging applications across healthcare, finance, cybersecurity, climate modeling, and materials science are also surveyed to highlight the real-world potential of QML.Furthermore, key challenges such as scalability, trainability issues, and algorithmic robustness are analyzed, along with current research efforts aimed at overcoming these barriers.The paper concludes by identifying promising future directions for advancing QML toward quantum advantage.This review aims to provide researchers and practitioners with a structured understanding of the capabilities, limitations, and opportunities of quantum machine learning in the NISQ era .
The current stage of quantum computing development is defined by Noisy Intermediate-Scale Quantum (NISQ) devices, which operate with a moderate number of qubits that are inherently susceptible to noise and decoherence. Despite the absence of full error correction, NISQ systems have demonstrated the ability to perform computational tasks that challenge classical simulation under certain conditions. This paper explores the concept of quantum advantage in the NISQ era by analysing prominent algorithmic approaches, benchmarking methodologies, and the practical constraints imposed by contemporary hardware. Hybrid quantum–classical algorithms, sampling-based experiments, and performance metrics are examined to assess the extent to which near-term quantum devices can outperform classical systems. The study finds that while progress toward quantum advantage is evident, significant technical and algorithmic limitations prevent its widespread realization. The paper concludes by identifying key research directions required to bridge the gap between experimental demonstrations and practical quantum computing applications.
Abstract Quantum simulation represents the most promising quantum application to demonstrate quantum advantage on near-term noisy intermediate-scale quantum (NISQ) computers, yet available quantum simulation algorithms are prone to errors and thus difficult to realize with limited circuit depth on nowadays quantum devices. Herein, we propose a novel scheme to utilize intrinsic gate errors of NISQ devices to enable controllable simulation of open quantum system dynamics without ancillary qubits or explicit bath engineering, thus turning unwanted quantum noises into useful quantum resources. Specifically, we simulate the energy transfer process in a photosynthetic dimer system on IBM-Q cloud. By employing tailored decoherence-inducing gates, we show that quantum dissipative dynamics can be simulated efficiently across coherent-to-incoherent regimes with results comparable to those of the numerically exact classical method. Moreover, we demonstrate a calibration routine that enables consistent and predictive simulations of open-quantum system dynamics in the intermediate coupling regime. This work provides a new direction for quantum advantage in the NISQ era.
<!--HTML-->A universal fault-tolerant quantum computer that can solve efficiently problems such as integer factorization and unstructured database search requires millions of qubits with low error rates and long coherence times. While the experimental advancement towards realizing such devices will potentially take decades of research, noisy intermediate-scale quantum (NISQ) computers already exist. These computers are composed of hundreds of noisy qubits, i.e. qubits that are not error-corrected, and therefore perform imperfect operations in a limited coherence time. In the search for quantum advantage with these devices, algorithms have been proposed for applications in various disciplines spanning physics, machine learning, quantum chemistry and combinatorial optimization. The goal of such algorithms is to leverage the limited available resources to perform classically challenging tasks. In this talk, I provide an overview of NISQ algorithms, their limitations and potential advantages.
Quantum computing is emerging as a transformative approach in bioinformatics and quantum chemistry, addressing fundamental computational limitations of classical methods in molecular science. Many biological and chemical systems are inherently governed by quantum mechanics, making accurate simulation with classical algorithms computationally expensive or infeasible. This review examines how quantum computing, particularly in the Noisy Intermediate-Scale Quantum (NISQ) era, is advancing molecular modeling, reaction dynamics, and bioinformatics applications. Key quantum algorithms, including the Variational Quantum Eigensolver (VQE) and Quantum Phase Estimation (QPE), demonstrate increasing capability in approximating molecular energies and simulating quantum systems. In parallel, applications in bioinformatics—such as protein folding, genomic search, and combinatorial optimization—highlight the potential of quantum computing to address complex biological problems. Quantum machine learning further extends these capabilities by integrating quantum algorithms with data-driven modeling. However, current progress is constrained by NISQ-era limitations, including noise, limited qubit counts, and scalability challenges. These constraints highlight the need for hybrid quantum–classical approaches and improved error mitigation strategies. Overall, quantum computing represents a complementary computational paradigm that can enhance classical methods in bioinformatics and chemistry. Continued advances in quantum algorithms, hardware, and hybrid modeling frameworks are expected to expand its role in molecular science and computational biology.
A universal fault-tolerant quantum computer that can solve efficiently problems such as integer factorization and unstructured database search requires millions of qubits with low error rates and long coherence times. While the experimental advancement towards realizing such devices will potentially take decades of research, noisy intermediate-scale quantum (NISQ) computers already exist. These computers are composed of hundreds of noisy qubits, i.e. qubits that are not error-corrected, and therefore perform imperfect operations in a limited coherence time. In the search for quantum advantage with these devices, algorithms have been proposed for applications in various disciplines spanning physics, machine learning, quantum chemistry and combinatorial optimization. The goal of such algorithms is to leverage the limited available resources to perform classically challenging tasks. In this review, we provide a thorough summary of NISQ computational paradigms and algorithms. We discuss the key structure of these algorithms, their limitations, and advantages. We additionally provide a comprehensive overview of various benchmarking and software tools useful for programming and testing NISQ devices.