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International Conference on Data Intelligence and Cognitive Informatics (ICDICI)

Quantum Machine Learning for Invasive Ductal Carcinoma Classification using Quantum Kernels

K. Dhanalakshmi, G. Nagarajan

Published Nov 18, 2024• 4 citations
Publisher

Abstract

This research study reviews the quantum kernel techniques and discusses about the application of a quantum machine learning model for the classification of breast cancer using Qiskit Machine learning version 0.4.0. This study applies ZZ-Feature Map to transform classical computer data into quantum states through the use of entanglement and superposition qualities characteristic of quantum mechanics. Then, a Quantum Kernel was created using the feature map and quantum instance (simulator) to compute similarity in data points in the space of a quantum state. It utilized this kernel to train QSVC - a quantum analogue of classical Support Vector Machine (SVM) with breast cancer data. With just two pivoting features for categorization, the resource limits obtained 70% overall accuracy. Preliminary Findings Using quantum kernel techniques improves the classification jobs via quantum computation.

DOI
10.1109/icdici62993.2024.10810956

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Quantum computing promises to revolutionize fields reliant on complex data processing, such as medical diagnostics. This paper presents an extended comparative analysis of classical and quantum machine learning (QML) techniques for breast cancer detection, using the Wisconsin Diagnostic Breast Cancer (WDBC) dataset. Classical kernel-based Support Vector Machines (SVMs) and Quantum Support Vector Classification (QSVC) using IBM's Qiskit platform are employed. Beyond accuracy comparisons, this study provides insights into the technical challenges of quantum feature encoding, computational overheads, and hardware limitations. Results suggest that while classical models currently dominate, QML represents a credible future pathway for handling large-scale, complex medical datasets.
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Quantum computing is a promising new approach to tackle the complex real-world computational problems by harnessing the power of quantum mechanics principles. The inherent parallelism and exponential computational power of quantum systems hold the potential to outpace classical counterparts in solving complex optimization problems, which are pervasive in machine learning. Quantum Support Vector Machine (QSVM) is a quantum machine learning algorithm inspired by classical Support Vector Machine (SVM) that exploits quantum parallelism to efficiently classify data points in high-dimensional feature spaces. We provide a comprehensive overview of the underlying principles of QSVM, elucidating how different quantum feature maps and quantum kernels enable the manipulation of quantum states to perform classification tasks. Through a comparative analysis, we reveal the quantum advantage achieved by these algorithms in terms of speedup and solution quality. As a case study, we explored the potential of quantum paradigms in the context of a real-world problem: classifying pancreatic cancer biomarker data. The Support Vector Classifier (SVC) algorithm was employed for the classical approach while the QSVM algorithm was executed on a quantum simulator provided by the Qiskit quantum computing framework. The classical approach as well as the quantum-based techniques reported similar accuracy. This uniformity suggests that these methods effectively captured similar underlying patterns in the dataset. Remarkably, quantum implementations exhibited substantially reduced execution times demonstrating the potential of quantum approaches in enhancing classification efficiency. This affirms the growing significance of quantum computing as a transformative tool for augmenting machine learning paradigms and also underscores the potency of quantum execution for computational acceleration.
Abstract Support vector machine(SVM) is one of the most popular machine learning(ML) methods which are widely used as the methodology of choice in Breast Cancer detection because of its unique advantages in critical features detection from complex breast cancer datasets. Quantum support vector machine(QSVM) uses the power of quantum mechanics to improve the performance of classical support vector machine(SVM) algorithms with theoretical acceleration advantage. However, it still suffers from the wide error problem and hardware limits in Noisy Intermediate-Scale Quantum computing(NISQ). Consequently, we propose a quantum kernel estimation method with measurement error mitigation and test it using the Wisconsin Breast Cancer database first on the IBM quantum processors. The experimental results show that we can achieve remarkable performance improvement in accuracy for solving such binary classification problems compared to state-of-the-art models, which shows the great potential for the design and implementation of machine learning algorithms with quantum advantages in the future.
The application of machine learning has shown significant progress in various fields, including clinical data classification. This study presents a comparative analysis between the classical Support Vector Machine (SVM) and Quantum Support Vector Machine (QSVM) for breast cancer classification using the Wisconsin Diagnostic Breast Cancer (WDBC) dataset. Principal Component Analysis (PCA) was applied as dimension reduction strategy across three configurations (PCA = 2, PCA = 4, and PCA = 6) to evaluate the sensitivity of both models to the feature space dimension. Preprocessing included log1p transformation on 22 skewed features, Manual SMOTE balancing, and MinMaxScaler normalization. SVM was optimized via GridSearchCV (80 parameter combinations, cv = 5), while QSVM employed a ZZFeatureMap quantum kernel (reps = 2, entanglement = full) on qasm_simulator. Experimental results demonstrate that SVM achieved superior accuracy across all configurations, with peak performance at PCA = 6 (Accuracy= 98.83%, AUC = 0.9985, Specificity = 1.0000, Sensitivity = 0.9688, Precision = 1.0000, NPV = 0.9817, and F1-score for malignant = 0.98). QSVM achieved its highest accuracy at PCA = 4 (92.98%), AUC = 0.9622, Sensitivity = 0.9219, Precision = 0.8939, NPV = 0.9524, and F1-score for malignant = 0.91. Across the three PCA configurations, QSVM exhibited a non-monotonic relationship between PCA dimensions and quantum kernel performance . These findings provide a quantitative benchmark for comparing quantum and classical machine learning in breast cancer diagnosis.
Current research paper presents a comparative analysis of classical and quantum machine learning algorithms for breast cancer diagnosis. The study focuses on two classical machine learning algorithms, XGBoost and SVM, along with two quantum models, Variational Quantum Classifier (VQC) and Quantum Support Vector Classifier (QSVC). The performance of the models is evaluated based on F1 score and recall. Results indicated that classic SVM and QSVC showed competitive results considering the other two algorithms regarding F1 score. This work contributes to the growing research on the application of classical and quantum ML algorithms in breast cancer classification.