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Advanced Quantum Technologies

Nonlinear Interferometry: A New Approach for Imaging and Sensing

Jorge Fuenzalida, Enno Giese, Markus Gräfe

Published May 22, 2024• 18 citations
Publisher

Abstract

Abstract Nonlinear interferometers are a ubiquitous tool in quantum photonics. As such, they allow spooky‐like imaging with undetected light. On the one side their working principle is based on the principle of induced coherence, which is deeply rooted in the heart of quantum mechanics. On the other side, they bear the strong potential to serve as new tool for biomedical imaging. In this review, an extensive overview about nonlinear interferometers and their working principle is given. A particular focus is set on their exploitation for quantum imaging and sensing. In addition, related side topics and further application fields as well as perspectives are provided.

DOI
10.1002/qute.202300353

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Abstract Nonlinear interferometers are a ubiquitous tool in quantum photonics. As such, they allow spooky‐like imaging with undetected light. On the one side their working principle is based on the principle of induced coherence, which is deeply rooted in the heart of quantum mechanics. On the other side, they bear the strong potential to serve as new tool for biomedical imaging. In this review, an extensive overview about nonlinear interferometers and their working principle is given. A particular focus is set on their exploitation for quantum imaging and sensing. In addition, related side topics and further application fields as well as perspectives are provided.
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Quantum imaging is emerging as a transformative approach for biomedical applications, applying nonclassical properties of light, such as entanglement, squeezing, and quantum correlations, to overcome fundamental limits of conventional techniques. These methods promise superior spatial resolution, enhanced signal-to-noise ratios, improved phase sensitivity, and reduced radiation dose, for potentially safer and more precise imaging for delicate biological samples. Here, we present an overview of quantum optical biomedical imaging technologies as well as quantum-inspired imaging methods, including quantum optical coherence tomography, quantum optical microscopy, ghost imaging, multi-parameter quantum imaging, and imaging with quantum-grade cameras. We describe the operating principles, biomedical applications, and unique advantages of each approach, along with the specific challenges for their translation into real-life practice. This review aims to guide future research toward advancing quantum imaging from experimental demonstrations to impactful biomedical tools.
Developing advanced technologies for sensing and imaging biological samples is crucial for medical applications, making quantum-enhanced methods particularly valuable, as they promise significant benefits over classical techniques. An important aspect of biological imaging is the characterization of tissue, which often involves resolving complex structural information such as birefringence and diattenuation. These measures require polarization-sensitive sensing which remains largely unaddressed in quantum-imaging techniques with undetected light. However, the bicolor nature and supreme phase sensitivity of nonlinear interferometers make them particularly advantageous for biological sensing. Hence, we theoretically introduce controllable polarizations of the interrogating light in a quantum-imaging setup and show the potential of nonlinear interferometers to simultaneously sense birefringence and diattenuation with undetected light while discussing both the low- and high-gain regime.
Owing to its capacity for unique (bio)-chemical specificity, microscopy with mid-infrared (IR) illumination holds tremendous promise for a wide range of biomedical and industrial applications. The primary limitation, however, remains detection, with current mid-IR detection technology often marrying inferior technical capabilities with prohibitive costs. Here, we experimentally show how nonlinear interferometry with entangled light can provide a powerful tool for mid-IR microscopy while only requiring near-IR detection with a silicon-based camera. In this proof-of-principle implementation, we demonstrate widefield imaging over a broad wavelength range covering 3.4 to 4.3 μm and demonstrate a spatial resolution of 35 μm for images containing 650 resolved elements. Moreover, we demonstrate that our technique is suitable for acquiring microscopic images of biological tissue samples in the mid-IR. These results form a fresh perspective for potential relevance of quantum imaging techniques in the life sciences.