Noisy intermediate-scale quantum (NISQ) computers are coming online. The lack of error-correction in these devices prevents them from realizing the full potential of fault-tolerant quantum computation, a technology that is known to have significant practical applications, but which is years, if not decades, away. A major open question is whether NISQ devices will have practical applications. In this thesis, we explore and implement proposals for using NISQ devices to achieve practical applications. In particular, we develop and execute variational quantum algorithms for solving problems in combinatorial optimization and quantum chemistry. We also execute a prototype of a protocol for generating certified random numbers. We perform our experiments on a superconducting qubit processor developed at Google. While we do not perform any quantum computations that are beyond the capabilities of classical computers, we address many implementation challenges that must be overcome to succeed in such an endeavor, including optimization, efficient compilation, and error mitigation. In addressing these challenges, we push the limits of what can currently be done with NISQ technology, going beyond previous quantum computing demonstrations in terms of the scale of our experiments and the types of problems we tackle. While our experiments demonstrate progress in the utilization of quantum computers, the limits that we reached underscore the fundamental challenges in scaling up towards the classically intractable regime. Nevertheless, our results are a promising indication that NISQ devices may indeed deliver practical applications.
Noisy intermediate-scale quantum (NISQ) computers are coming online. The lack of error-correction in these devices prevents them from realizing the full potential of fault-tolerant quantum computation, a technology that is known to have significant practical applications, but which is years, if not decades, away. A major open question is whether NISQ devices will have practical applications. In this thesis, we explore and implement proposals for using NISQ devices to achieve practical applications. In particular, we develop and execute variational quantum algorithms for solving problems in combinatorial optimization and quantum chemistry. We also execute a prototype of a protocol for generating certified random numbers. We perform our experiments on a superconducting qubit processor developed at Google. While we do not perform any quantum computations that are beyond the capabilities of classical computers, we address many implementation challenges that must be overcome to succeed in such an endeavor, including optimization, efficient compilation, and error mitigation. In addressing these challenges, we push the limits of what can currently be done with NISQ technology, going beyond previous quantum computing demonstrations in terms of the scale of our experiments and the types of problems we tackle. While our experiments demonstrate progress in the utilization of quantum computers, the limits that we reached underscore the fundamental challenges in scaling up towards the classically intractable regime. Nevertheless, our results are a promising indication that NISQ devices may indeed deliver practical applications.
Quantum computing has transitioned from a theoretical curiosity to an emerging technological paradigm with demonstrable computational advantages in specific problem domains. This paper presents a comprehensive review of current advances in quantum computing hardware, software, and near-term applications within the Noisy Intermediate-Scale Quantum (NISQ) era. We examine the architectural evolution of leading quantum platforms, including superconducting, trapped-ion, and photonic systems, analyzing their qubit counts, gate fidelities, and coherence times. The paper evaluates key quantum algorithms Shor's factoring algorithm [1], Grover's search algorithm [2], the Variational Quantum Eigensolver (VQE) [3], and the Quantum Approximate Optimization Algorithm (QAOA) [4] in the context of their practical applicability to real-world problems. We further discuss the milestone of quantum computational advantage demonstrated by Google's Sycamore processor [5] and IBM's ambitious hardware roadmap toward fault-tolerant quantum computing [6]. Our analysis reveals that while universal fault-tolerant quantum computing remains a long-term objective, NISQ-era devices are already yielding valuable results in quantum chemistry simulation, combinatorial optimization, and quantum machine learning. We conclude by identifying the critical challenges—error correction, scalability, and algorithm design that must be addressed to realize the full potential of quantum computing.
A universal fault-tolerant quantum computer that can solve efficiently problems such as integer factorization and unstructured database search requires millions of qubits with low error rates and long coherence times. While the experimental advancement towards realizing such devices will potentially take decades of research, noisy intermediate-scale quantum (NISQ) computers already exist. These computers are composed of hundreds of noisy qubits, i.e. qubits that are not error-corrected, and therefore perform imperfect operations in a limited coherence time. In the search for quantum advantage with these devices, algorithms have been proposed for applications in various disciplines spanning physics, machine learning, quantum chemistry and combinatorial optimization. The goal of such algorithms is to leverage the limited available resources to perform classically challenging tasks. In this review, we provide a thorough summary of NISQ computational paradigms and algorithms. We discuss the key structure of these algorithms, their limitations, and advantages. We additionally provide a comprehensive overview of various benchmarking and software tools useful for programming and testing NISQ devices.
Quantum computing has emerged as a transformative paradigm capable of addressing computational challenges beyond the reach of classical systems.In the current era of Noisy Intermediate-Scale Quantum (NISQ) devices, practical quantum hardware is characterized by limited qubit counts, short coherence times, gate errors, and the absence of full error correction.Despite these constraints, significant progress has been made in developing quantum machine learning (QML) techniques tailored to operate on near-term quantum processors.This paper presents a comprehensive review of Quantum Machine Learning in the context of NISQ computing.We first outline the fundamental principles of quantum computing, including qubits, superposition, entanglement, and quantum parallelism, followed by a detailed discussion of the NISQ computing model and its hardware limitations.The review then examines hybrid quantum-classical learning frameworks, variational quantum algorithms, quantum data encoding strategies, and noise mitigation techniques that enable practical implementation on existing platforms.Emerging applications across healthcare, finance, cybersecurity, climate modeling, and materials science are also surveyed to highlight the real-world potential of QML.Furthermore, key challenges such as scalability, trainability issues, and algorithmic robustness are analyzed, along with current research efforts aimed at overcoming these barriers.The paper concludes by identifying promising future directions for advancing QML toward quantum advantage.This review aims to provide researchers and practitioners with a structured understanding of the capabilities, limitations, and opportunities of quantum machine learning in the NISQ era .
<!--HTML-->A universal fault-tolerant quantum computer that can solve efficiently problems such as integer factorization and unstructured database search requires millions of qubits with low error rates and long coherence times. While the experimental advancement towards realizing such devices will potentially take decades of research, noisy intermediate-scale quantum (NISQ) computers already exist. These computers are composed of hundreds of noisy qubits, i.e. qubits that are not error-corrected, and therefore perform imperfect operations in a limited coherence time. In the search for quantum advantage with these devices, algorithms have been proposed for applications in various disciplines spanning physics, machine learning, quantum chemistry and combinatorial optimization. The goal of such algorithms is to leverage the limited available resources to perform classically challenging tasks. In this talk, I provide an overview of NISQ algorithms, their limitations and potential advantages.
The recent pace of experimental progress in quantum technologies suggests we may soon reach a time when quantum devices can be applied to solve problems of practical interest. Despite this, we are still far from being able to abstract away the effects of noise on quantum computation. The reliable execution of computations on current devices remains a significant challenge. This holds true both for computation with noisy physical qubits and for computation using the limited forms of error correction available on early fault-tolerant quantum devices. In this thesis, I propose methods for improving the reliability of quantum devices, as the field transitions from the regime of noisy intermediate-scale quantum (NISQ) devices to that of early fault-tolerance. These span the topics of quantum error mitigation, quantum error correction and quantum certification. In the first instance, I propose methods for improving the performance of quantum devices affected by limited amounts of noise. Specifically, I present a method for mitigating the effects of time-dependent noise. This adapts a computational certification protocol called accreditation into a method for postselecting on weaker time-dependent noise behaviours. The method is analytically shown to lead to a provable reduction in errors for the case of depolarising noise, and demonstrated in experiments on superconducting hardware. I also present a method for mitigating the effects of photon loss in photonic quantum devices. Through a combination of analytical and numerical analysis, it is shown that there are wide regimes of photon loss for which this method outperforms postselection, the standard method of handling loss in photonic devices. Additionally, evidence is provided that the method enhances the performance of a quantum machine learning model known as a Quantum Circuit Born Machine in the presence of photon loss. Next, I introduce a framework for certifying the correctness of computations run on encoded logical qubits. This is sensitive to considerably more general forms of noise than is usually considered in quantum error correction. It can be applied to efficiently certify the correctness of quantum computations for large system sizes, beyond the capabilities of methods relying on classical simulation. In numerical experiments, the framework was applied to certify the accuracy of instantaneous quantum polynomial (IQP) circuit sampling and Trotterised Hamiltonian simulation. It can be used to efficiently assess whether quantum error mitigation may be usefully applied to a computation, to upper-bound the infidelity of the encoded logical state, and to extend the method of entropy density benchmarking to logical computation. The methods presented in this thesis contribute to the wider effort of building towards reliable quantum computation: both in the sense of reducing the effects of noise on computational output, and in the sense of certifying the correctness of computation beyond the capabilities of classical simulators. Only with reliable quantum computation can the full potential of this technology be realised.
In 2017, John Preskill defined Noisy Intermediate Scale Quantum (NISQ) computers as an intermediate step on the road to large scale error corrected fault-tolerant quantum computers (FTQC). The NISQ regime corresponds to noisy qubit quantum computers with the potential to solve actual problems of some commercial value faster than conventional supercomputers, or consuming less energy. Over five years on, it is a good time to review the situation. While rapid progress is being made with quantum hardware and algorithms, and many recent experimental demonstrations, no one has yet successfully implemented a use case matching the original definition of the NISQ regime. This paper investigates the space, fidelity and time resources of various NISQ algorithms and highlights several contradictions between NISQ requirements and actual as well as future quantum hardware capabilities. It then covers various techniques which could help like qubit fidelities improvements, various breeds of quantum error mitigation methods, analog/digital hybridization, using specific qubit types like multimode photons as well as quantum annealers and analog quantum computers (aka quantum simulators or programmable Hamiltonian simulators) which seem closer to delivering useful applications although they have their own mid to longer-term scalability challenges. Given all the constraints of these various solutions, it seems possible to expect some practical use cases for NISQ systems, but with a very narrow window before various scaling issues show up. Turning to the future, a scenario can be envisioned where NISQ will not necessarily be an intermediate step on the road to FTQC. Instead, the two may develop along different paths, due to their different requirements. This leaves open a key question on the trade-offs that may be necessary to make between qubit scale and qubit fidelities in future quantum computers designs.