This thesis aims to legitimize the inclusion of action at a distance in scientific theories. I approach this task from two angles. In the first part, I show that action at a distance is a genuine metaphysical possibility. To do so, I examine how theorists in the history of science have justified their assumption of locality (and find these justifications inadequate), reconcile action at a distance with scientific explanation and show that it is not a threat to causation. In the second part, I consider an actual instance of action at a distance in nature: quantum nonlocality. Since action at a distance cannot be excluded through reason alone, if experience indicates action at a distance one may call it as such. I argue that action at a distance is the most viable theory by which to interpret quantum nonlocality.