Abstract We extend quantum Stein’s lemma in asymmetric quantum hypothesis testing to composite null and alternative hypotheses. As our main result, we show that the asymptotic error exponent for testing convex combinations of quantum states
ρ⊗n ρ ⊗ n against convex combinations of quantum states
σ⊗n σ ⊗ n can be written as a regularized quantum relative entropy formula. We prove that in general such a regularization is needed but also discuss various settings where our formula as well as extensions thereof become single-letter. This includes an operational interpretation of the relative entropy of coherence in terms of hypothesis testing. For our proof, we start from the composite Stein’s lemma for classical probability distributions and lift the result to the non-commutative setting by using elementary properties of quantum entropy. Finally, our findings also imply an improved recoverability lower bound on the conditional quantum mutual information in terms of the regularized quantum relative entropy—featuring an explicit and universal recovery map.