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arXiv:2607.12182

Roadmap Towards Quantum Entanglement Positron Emission Tomography (QE-PET)

Paweł Moskal, Shiva Abbaszadeh, Harmanjeet Singh Bilkhu, Peter Caradonna, Pragya Das, Praveen Gurunath Bharathi, Ana Marija Kožuljević, Zdenka Kuncic, Deepak Kumar, Mihael Makek, Marek Nowakowski, Siddharth Parashari, Kaustav Prasad, Gregory R. Romanchek, Sushil Sharma, Kenji Shimazoe, Ewa Stępień, Sodai Takyu, Miwako Takahashi, Mizuki Uenomachi, Ritesh Verma, Taiga Yamaya

physics.med-phquant-phSubmitted Jul 13, 2026• Announced Jul 15, 2026• 0 citations
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Abstract

Annihilation photons are quantum entangled in their polarization, a property that is not accessible in state-of-the-art clinical Positron Emission Tomography (PET). This roadmap describes the current status of research in the emerging field of quantum entanglement applications involving these photons for medical diagnosis. It outlines the underlying physics phenomena and the development of detector systems that can serve as a foundation for future Quantum Entanglement PET (QE-PET) scanners. These scanners will be capable of utilizing the entanglement between annihilation photons by measuring their Compton scattering on electrons. This roadmap comprises up-to-date experimental results on the study of quantum entanglement and the decoherence of annihilation photons, alongside the current theoretical understanding of these phenomena. The methods and detector technologies described herein are being developed (i) in order to enhance standard PET imaging by suppressing random coincidences in the reconstruction of annihilation site density distributions, (ii) in order to establish the degree of quantum entanglement as a diagnostic biomarker for tissue pathology and oxygenation, and (iii) in order to elaborate a method for pH imaging. Whether entanglement-based imaging and pH mapping can be successfully translated into clinical practice remains an open question and a subject of exciting ongoing research. This roadmap serves as an invitation to the scientific community to join this burgeoning field.

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The entanglement of photons originating from electron-positron annihilation has not been experimentally proven.owever, the independent experiments performed so far unanimously confirm that the correlation between the linear polarizations of back-to-back photons from electron-positron annihilation is consistent with the assumption that these photons are entangled in the polarization.Yet, unexpectedly, recent experiments differ as regards the correlation of polarization direction of back-to-back photons after the decoherence induced by the scattering of one of these photons on the electron in the scattering material.In one of the experiments, the correlation before and after the decoherence of the photon state is the same, and in the other experiment, the scattering of one photon leads to a significant decrease in this correlation.Here we discuss this puzzle.Decoherent states were ensured provided by forcing one of the annihilation photons to scatter earlier before measuring the polarization correlation based on Compton kinematics.The comparison is made between the experimental setups used for the different measurements, and the results obtained are briefly discussed, highlighting the parameters that are important in performing such measurements.Finally, the main features of the J-PET detector are presented, along with the schemes for performing similar studies, so that the conclusive results can be used as remarks to solve the puzzle in question.Solving the decoherence puzzle will have crucial consequences for basic studies of entanglement, as well as for the proposed application of the photon polarization in positron emission tomography.If the correlation of the polarization of back-to-back photons from the electron-positron annihilation is the same before and after the scattering of these photons, then it will not be useful for the reduction of scatter fraction in positron emission tomography diagnostics.

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Annihilation photons are quantum entangled in their polarization, a property that is not accessible in state-of-the-art clinical Positron Emission Tomography (PET). This roadmap describes the current status of research in the emerging field of quantum entanglement applications involving these photons for medical diagnosis. It outlines the underlying physics phenomena and the development of detector systems that can serve as a foundation for future Quantum Entanglement PET (QE-PET) scanners. These scanners will be capable of utilizing the entanglement between annihilation photons by measuring their Compton scattering on electrons. This roadmap comprises up-to-date experimental results on the study of quantum entanglement and the decoherence of annihilation photons, alongside the current theoretical understanding of these phenomena. The methods and detector technologies described herein are being developed (i) in order to enhance standard PET imaging by suppressing random coincidences in the reconstruction of annihilation site density distributions, (ii) in order to establish the degree of quantum entanglement as a diagnostic biomarker for tissue pathology and oxygenation, and (iii) in order to elaborate a method for pH imaging. Whether entanglement-based imaging and pH mapping can be successfully translated into clinical practice remains an open question and a subject of exciting ongoing research. This roadmap serves as an invitation to the scientific community to join this burgeoning field.
Positron Emission Tomography (PET) is a widely-used imaging modality for medical research and clinical diagnosis. Imaging of the radiotracer is obtained from the detected hit positions of the two positron annihilation photons in a detector array. The image is degraded by backgrounds from random coincidences and in-patient scatter events which require correction. In addition to the geometric information, the two annihilation photons are predicted to be produced in a quantum-entangled state, resulting in enhanced correlations between their subsequent interaction processes. To explore this, the predicted entanglement in linear polarisation for the two photons was incorporated into a simulation and tested by comparison with experimental data from a cadmium zinc telluride (CZT) PET demonstrator apparatus. Adapted apparati also enabled correlation measurements where one of the photons had undergone a prior scatter process. We show that the entangled simulation describes the measured correlations and, through simulation of a larger preclinical PET scanner, illustrate a simple method to quantify and remove the unwanted backgrounds in PET using the quantum entanglement information alone.
Annihilation photons are quantum-entangled in polarization, a phenomenon that has not been exploited in medical diagnostics so far. We present the first in vivo imaging of the degree of quantum entanglement of photons originating from positron-electron annihilation within a human subject. This study utilized the Jagiellonian Positron Emission Tomography (J-PET) scanner, constructed from plastic scintillators. In plastics, annihilation photons interact primarily via the Compton effect, which provides simultaneous information regarding the photon interaction position and time, as well as the photon polarization plane. The patient was injected with a DOTA-TATE radiopharmaceutical labeled with the 68^{68}68Ga radionuclide. Using the J-PET scanner, we determined the image of the radiopharmaceutical uptake and, simultaneously, the image of the degree of quantum entanglement. The latter was determined from the relative angle between the polarization planes of the annihilation photons. The values of the degree of quantum entanglement extracted for the liver and the spleen are smaller than those predicted for maximally entangled two-photon states, yet larger than expected for separable photons. This demonstration opens new perspectives for the application of quantum entanglement in clinical diagnostics.
Exploitation of the implicit quantum entanglement (QE) of the two gamma-photons in PET for improving image quality is a novel new methodology proposed only recently e.g [1]. However progress in this new area had been hindered due to lack of theoretical understanding or experimental constraint on how the initial QE can be dispersed to the envirionment through decoherence. Such processes will have significant role in PET imaging through scatter processes in the patient, bed or the detector crystals. The role of such processes will be significantly enhanced in next-generation fully body PET.Addressing this major gap in our knowledge of QE decoherence is a key aim of the new MeVQE collaboration, an interdisciplinary grouping of nuclear physicists, quantum information theorists and mathematicians based at the University of York. The first theoretical calculation of the decoherence of QE for PET photons will be presented [2]. Predictions from the new theory are challenged with a first detailed experimental determination of the triple Compton scattering of entangled gamma photons [3]. The work provides a paradigm shift in our understanding of QE decoherence for PET photons. In addition a further key measurement for the field will be presented, the first determination of the QE witness in a relistic preclinical scenario viz. 18-F source with gamma produced from annihilation in tissue (mouse heart). The future programme of MeVQE in establishing QEPET will also be outlined.
In state-of-the-art positron emission tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via the Compton effect, providing information about both photon polarization and propagation direction. Using this plastic-based PET, we determined the distribution of the relative angle between polarization planes of photons from positron-electron annihilation in a porous polymer. The amplitude of the observed distribution is smaller than predicted for maximally quantum entangled two-photon states but larger than expected for separable photons. This result can be well explained by assuming that photons from pick-off annihilation are not entangled, while photons from direct and parapositronium annihilations are maximally entangled. Our result indicates that the degree of entanglement depends on the annihilation mechanism in matter, opening avenues for exploring polarization correlations in PET as a diagnostic indicator.
Abstract Quantum electrodynamics (QED) predicts that photons from positronium decay are maximally entangled. However, experimental verification of this entanglement in high-energy photons has remained elusive due to competing decay processes and interactions with the surrounding medium. The J-PET detector is a multi-modules detector based on plastic scintillators that has the potential to measure such correlation in the whole phase space. Photons interact with plastic mainly via Compton scattering, which makes J-PET particularly suitable for this type of study. Moreover, by incorporating the positron lifetime as an additional parameter, to differentiate between various decay processes and examine how the polarization correlation changes as a function of lifetime. Such studies provide new insights into quantum entanglement at high energy regimes and hold potential to enhance positron emission tomography (PET) imaging techniques. Recent results demonstrate the J-PET detector’s capability to measure the polarization correlation of photons emitted from positron annihilation in a porous medium. In this paper, we present a review of past research in this field, highlighting the need for further investigation of polarization correlation of annihilation photons.
The entanglement of photons originating from electron-positron annihilation has not been experimentally proven.owever, the independent experiments performed so far unanimously confirm that the correlation between the linear polarizations of back-to-back photons from electron-positron annihilation is consistent with the assumption that these photons are entangled in the polarization.Yet, unexpectedly, recent experiments differ as regards the correlation of polarization direction of back-to-back photons after the decoherence induced by the scattering of one of these photons on the electron in the scattering material.In one of the experiments, the correlation before and after the decoherence of the photon state is the same, and in the other experiment, the scattering of one photon leads to a significant decrease in this correlation.Here we discuss this puzzle.Decoherent states were ensured provided by forcing one of the annihilation photons to scatter earlier before measuring the polarization correlation based on Compton kinematics.The comparison is made between the experimental setups used for the different measurements, and the results obtained are briefly discussed, highlighting the parameters that are important in performing such measurements.Finally, the main features of the J-PET detector are presented, along with the schemes for performing similar studies, so that the conclusive results can be used as remarks to solve the puzzle in question.Solving the decoherence puzzle will have crucial consequences for basic studies of entanglement, as well as for the proposed application of the photon polarization in positron emission tomography.If the correlation of the polarization of back-to-back photons from the electron-positron annihilation is the same before and after the scattering of these photons, then it will not be useful for the reduction of scatter fraction in positron emission tomography diagnostics.