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arXiv:2606.29421

First-in-human quantum entanglement imaging

Pawel Moskal, Deepak Kumar, Sushil Sharma, Ermias Y. Beyene, Neha Chug, Catalina Curceanu, Eryk Czerwiński, Atharva Dalvi, Manish Das, Alicja Hubalewska-Dydejczyk, Sharareh Jalali, Krzysztof Kacprzak, Tevfik Kaplanoglu, Łukasz Kapłon, Kamila Kasperska, Aleksander Khreptak, Grzegorz Korcyl, Tomasz Kozik, Sumit Kumar Kundu, Anoop Kunimmal Venadan, Bartosz Leszczyński, Edward Lisowski, Filip Lisowski, Justyna Mędrala-Sowa, Simbarashe Moyo, Wiktor Mryka, Szymon Niedźwiecki, Marta Opalińska, Anand Pandey, Piyush Pandey, Alessio Porcelli, Bartłomiej Rachwał, Magdalena Skurzok, Anna Sowa-Staszczak, Tomasz Szumlak, Satyam Tiwari, Pooja Tanty, Keyvan Tayefi Ardebili, Kavya Valsan Eliyan, Ewa Ł. Stepień

physics.med-phquant-phSubmitted Jun 28, 2026• Announced Jun 30, 2026• 0 citations
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Abstract

Annihilation photons are quantum-entangled in polarization, a phenomenon that has not been exploited in medical diagnostics so far. We present the first in vivo imaging of the degree of quantum entanglement of photons originating from positron-electron annihilation within a human subject. This study utilized the Jagiellonian Positron Emission Tomography (J-PET) scanner, constructed from plastic scintillators. In plastics, annihilation photons interact primarily via the Compton effect, which provides simultaneous information regarding the photon interaction position and time, as well as the photon polarization plane. The patient was injected with a DOTA-TATE radiopharmaceutical labeled with the $^{68}$Ga radionuclide. Using the J-PET scanner, we determined the image of the radiopharmaceutical uptake and, simultaneously, the image of the degree of quantum entanglement. The latter was determined from the relative angle between the polarization planes of the annihilation photons. The values of the degree of quantum entanglement extracted for the liver and the spleen are smaller than those predicted for maximally entangled two-photon states, yet larger than expected for separable photons. This demonstration opens new perspectives for the application of quantum entanglement in clinical diagnostics.

Comments
27 pages, 4 figures. Corresponding author: P. Moskal (p.moskal@uj.edu.pl)

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Annihilation photons are quantum-entangled in polarization, a phenomenon that has not been exploited in medical diagnostics so far. We present the first in vivo imaging of the degree of quantum entanglement of photons originating from positron-electron annihilation within a human subject. This study utilized the Jagiellonian Positron Emission Tomography (J-PET) scanner, constructed from plastic scintillators. In plastics, annihilation photons interact primarily via the Compton effect, which provides simultaneous information regarding the photon interaction position and time, as well as the photon polarization plane. The patient was injected with a DOTA-TATE radiopharmaceutical labeled with the 68^{68}68Ga radionuclide. Using the J-PET scanner, we determined the image of the radiopharmaceutical uptake and, simultaneously, the image of the degree of quantum entanglement. The latter was determined from the relative angle between the polarization planes of the annihilation photons. The values of the degree of quantum entanglement extracted for the liver and the spleen are smaller than those predicted for maximally entangled two-photon states, yet larger than expected for separable photons. This demonstration opens new perspectives for the application of quantum entanglement in clinical diagnostics.
In state-of-the-art Positron Emission Tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via the Compton effect, providing information about both photon polarization and propagation direction. Using this plastic-based PET, we determined the distribution of the relative angle between polarization planes of photons from positron-electron annihilation in a porous polymer. The amplitude of the observed distribution is smaller than predicted for maximally quantum-entangled two-photon states but larger than expected for separable photons. This result can be well explained by assuming that photons from pick-off annihilation are not entangled, while photons from direct and para-positronium annihilations are maximally entangled. Our result indicates that the degree of entanglement depends on the annihilation mechanism in matter, opening new avenues for exploring polarization correlations in PET as a diagnostic indicator.
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In state-of-the-art positron emission tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via the Compton effect, providing information about both photon polarization and propagation direction. Using this plastic-based PET, we determined the distribution of the relative angle between polarization planes of photons from positron-electron annihilation in a porous polymer. The amplitude of the observed distribution is smaller than predicted for maximally quantum entangled two-photon states but larger than expected for separable photons. This result can be well explained by assuming that photons from pick-off annihilation are not entangled, while photons from direct and parapositronium annihilations are maximally entangled. Our result indicates that the degree of entanglement depends on the annihilation mechanism in matter, opening avenues for exploring polarization correlations in PET as a diagnostic indicator.
Quantum entanglement is one of the fundamental correlations between particles that has not yet been confirmed with high-energy photons. Quantum electrodynamics (QED) predicts that annihilation photons produced by the decay of the singlet state of positronium (Ps) atoms are entangled in their polarization. Since these photons have an energy of 511 keV, there is no polarizer to measure the polarization of these photons. However, the direction of the scattering photons when interacting with an electron via the Compton process depends strongly on the polarization of the photon. Therefore, Compton scattering can be used as a polarization analyser. The polarization direction of the photon can be defined as the cross product of the momentum vector of the incident and scattered photon. By measuring the polarization of annihilation photons originating from Ps decays, their polarization correlation can be determined. Measuring this correlation will for the first time, will answer the open question of studying quantum entanglement in high-energy photons. Moreover, it also have potential applications in PET imaging, where the quality of image reconstruction directly depends on the selection of pure annihilation photons, which can be separated based on the strength of the polarization correlation. In this paper, we report on the method for determining the polarization correlation of annihilation photons using the J-PET detector.
Positron Emission Tomography (PET) is a widely-used imaging modality for medical research and clinical diagnosis. Imaging of the radiotracer is obtained from the detected hit positions of the two positron annihilation photons in a detector array. The image is degraded by backgrounds from random coincidences and in-patient scatter events which require correction. In addition to the geometric information, the two annihilation photons are predicted to be produced in a quantum-entangled state, resulting in enhanced correlations between their subsequent interaction processes. To explore this, the predicted entanglement in linear polarisation for the two photons was incorporated into a simulation and tested by comparison with experimental data from a cadmium zinc telluride (CZT) PET demonstrator apparatus. Adapted apparati also enabled correlation measurements where one of the photons had undergone a prior scatter process. We show that the entangled simulation describes the measured correlations and, through simulation of a larger preclinical PET scanner, illustrate a simple method to quantify and remove the unwanted backgrounds in PET using the quantum entanglement information alone.
Abstract Quantum electrodynamics (QED) predicts that photons from positronium decay are maximally entangled. However, experimental verification of this entanglement in high-energy photons has remained elusive due to competing decay processes and interactions with the surrounding medium. The J-PET detector is a multi-modules detector based on plastic scintillators that has the potential to measure such correlation in the whole phase space. Photons interact with plastic mainly via Compton scattering, which makes J-PET particularly suitable for this type of study. Moreover, by incorporating the positron lifetime as an additional parameter, to differentiate between various decay processes and examine how the polarization correlation changes as a function of lifetime. Such studies provide new insights into quantum entanglement at high energy regimes and hold potential to enhance positron emission tomography (PET) imaging techniques. Recent results demonstrate the J-PET detector’s capability to measure the polarization correlation of photons emitted from positron annihilation in a porous medium. In this paper, we present a review of past research in this field, highlighting the need for further investigation of polarization correlation of annihilation photons.