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arXiv:2606.28252

Parameter-Efficient Continuous-Variable Photonic Quantum Neural Networks for Edge Quantum AI: Demonstration in Oral Cancer Detection

Akshay Bhagwan Sonawane, Sophie Choe, Lakshman Tamil

quant-phcs.LGSubmitted Jun 26, 2026• Announced Jun 29, 2026• 0 citations
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Abstract

Early detection of oral cancer markedly improves clinical outcomes, yet specialized diagnostic tools remain scarce in low-resource settings. Smartphone-based screening is a scalable alternative but needs lightweight models that run within edge-hardware constraints. Hybrid classical-quantum architectures are emerging candidates for parameter-efficient learning, yet most rely on qubit hardware that needs cryogenic operation, unsuitable for edge deployment. Continuous-variable (CV) photonic quantum computing, which operates at room temperature, offers a complementary route. We investigate a hybrid classical-CV quantum classifier for oral cancer detection from smartphone images. The pipeline combines a MobileNetV1 feature extractor, principal component analysis to 16 dimensions, and a parameterized CV-QNN of displacement, interferometric, and Kerr gates on a photonic backend. We propose a simplified $Φ\circ D \circ U_1$ CV-QNN architecture that cuts trainable parameters 40-45% relative to the standard CV-QNN layer of Killoran et al. (2019a), and identify dimensionality-reduction and encoding-restriction strategies that mitigate barren plateaus, raising loss-gradient variance by roughly 58 orders of magnitude. Whether the simplified layer beats the full layer is width-dependent: the full layer holds a small but significant edge at two qumodes, whereas the simplified layer is significantly better at four qumodes using 44% fewer parameters. The strongest model, a four-qumode simplified CV-QNN with only 18 parameters, attains the highest validation AUC of all models, exceeds a 55-parameter classical baseline using 67% fewer parameters, and reaches 100% calibrated test accuracy across all seeds. These results support CV photonic quantum machine learning for parameter-efficient, room-temperature medical image classification and motivate progress toward edge quantum AI.

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Audio classification is a key application in deep learning, and quantum machine learning (QML) provides new possibilities by capturing complex patterns in signals through parameterized quantum circuits. However, existing qubit-based models struggle to efficiently represent continuous-valued data common in audio processing, limiting their scalability and expressivity. Continuous Variable Quantum Computing (CVQC) offers a natural framework for processing real-valued data such as mel-spectrograms, addressing the limitations of qubit-based systems while introducing nonlinearity through non-gaussian gates to ensure universality. In CVQC, each qumode represents an infinite-dimensional Hilbert space, enabling compact yet expressive information representation. This work introduces a two-qumode Hybrid Continuous Variable Quantum Neural Network (HCVQNN) for audio classification that integrates classical neural layers with a CV quantum circuit for advanced feature extraction and encoding. Experiments conducted using PennyLane demonstrate that HCVQNN achieves comparable audio classification accuracy while requiring fewer resources compared to classical deep networks and qubit-based quantum models.
Early diagnosis of breast cancer is crucial to combat its severity. Yet, it’s a challenging endeavor to tackle via traditional diagnosis methods. Several machine learning architectures have already been proposed to assist medical experts in diagnosis. However, architectural complexity hinders the goal of developing a cost-effective diagnosis model. Recently, quantum computing has become popular in machine learning due to its potential computational benefits. Although quantum computing has yet to show any significant improvement in machine learning due to its limited resources and complexity, it may reduce the computational complexity of machine learning in the future. Therefore, we proposed a novel hybrid classical-quantum machine learning model for breast cancer prediction. We collected the BreastMNIST dataset of 780 benign and malignant full-image mammogram samples. Our task is to create an efficient breast cancer-classifying hybrid machine learning model. The proposed method employs a modified ResNet50 as a feature extractor and a Quantum Neural Network to train on that feature and generate desired predictions. A Convolutional layer is applied as a dimension-reduction technique for features generated through ResNet50. Our architecture proved superior to other state-of-the-art hybrid methods, achieving an accuracy of 69% against 67%. An in-depth comparative analysis has been performed that shows the novelty of our research. This study paves the path for hybrid classical-quantum machine learning research in medical image classification.
Purpose This study investigates the integration of quantum-enhanced machine learning (QML) into medical image analysis, focusing on classification and feature extraction tasks. It aims to evaluate whether hybrid quantum-classical models can overcome the limitations of traditional machine learning in handling high-dimensional, clinically relevant imaging data. Design/methodology/approach Hybrid architectures combining classical preprocessing with quantum components, specifically variational quantum circuits (VQCs) and quantum kernel methods, were developed and implemented in simulated quantum environments using Qiskit and PennyLane on Google Colab. Publicly available datasets (ChestX-ray14, Brain Tumor MRI and CT Hemorrhage) were preprocessed and encoded into quantum states. Model performance was evaluated against classical baselines (MLP and CNN) using accuracy, precision, recall, F1-score, convergence speed and trainable parameters. Findings Quantum-enhanced models achieved competitive or superior performance compared to classical models with significantly fewer trainable parameters and faster convergence. The Quantum Kernel SVM demonstrated the highest precision (89.1%) and F1-score (88.5%) using only 8 parameters, while VQC models converged up to 2× faster than classical baselines. These results highlight the potential of QML to improve efficiency, robustness and scalability in diagnostic imaging workflows, particularly in resource-constrained or data-limited settings. Research limitations/implications The study relies on simulated quantum environments, which do not capture hardware noise or qubit limitations. Future work will extend to real quantum devices, multimodal data integration and interpretability strategies. Practical implications Quantum kernel methods and lightweight VQC architectures enable faster, resource-efficient diagnostic modeling, making them suitable for clinical environments with limited computational capacity or time-sensitive decision-making needs. Social implications Improving the efficiency and accessibility of medical image analysis has the potential to support faster diagnosis and enhance healthcare delivery, particularly in underserved or resource-limited regions. Originality/value This study provides a practical evaluation of hybrid quantum-classical models applied to multiple real medical imaging datasets in a reproducible simulated environment. It offers an early-stage framework demonstrating how QML techniques can be integrated into existing machine learning pipelines for medical image analysis.
Abstract Neuro-imaging data is necessary for timely and correct diagnosis of the disease Alzheimer’s (AD). Early clinical intervention is challenging due to the high-dimensional nature of the images, making it computationally difficult to work on representations, sparse annotated datasets and inter-subject variance. Deep convolutional VGG, ResNet, DenseNet, MobileNet and other neural networks (CNNs) have shown good performance. Diagnostic performance, but they are based on a high number of parameters and require highly trained personnel. Data can often times restrict resilience to data-skimy clinical settings. To address these challenges, the current paper presents a hybrid Quantum Machine Learning (QML) architecture for Alzheimer’s disease Detection and classification based on a combination of classical CNN-based feature extraction and Variational quantum classifier. In the suggested method, diseased, relevant, and compact features are extracted using pre-trained CNN backbones. Data from structural MRI scans is later translated into quantum states and computed. With parameterised variational quantum circuits optimised with a hybrid quantum-classical learning loop. The proposed method has been experimentally evaluated on benchmark datasets of MRI scans of Alzheimer’s patients. The hybrid CNNQML model has a mean classification accuracy of about 93% which is similar to deep CNN models, including ResNet and DenseNet (94%), and much more. Beating lightweight models like MobileNet and shallow CNNs by six percentage points. It is worth noting that the hybrid QML model performs better in conditions with limited training data. Performance degradation is observed in accuracy and AUC for all CNN variants, with up to 5% lower performance to deep CNNs. Cross-validation, confidence interval, paired significance test, and statistical validation. Effect size analysis proves the fact that the hybrid model produces statistically significant performance, as well as cases of clinically meaningful improvements over lightweight CNN baselines. Similar to the state-of-the-art deep networks with significantly reduced trainable parameters in the classification stage. These findings show that hybrid QML is a data-efficient and powerful substitute in the diagnosis of Alzheimer’s. On the whole, this is a work that sets a practical way to integrate quantum machine learning into clinical neuro-imaging pipelines and hybrid settings. QML has supplementary deep-learning enhancement to classics in next-generation Alzheimer’s Decision-support systems.
In this paper, classical and continuous variable (CV) quantum neural network hybrid multiclassifiers are presented using the MNIST dataset. The combination of cutoff dimension and probability measurement method in the CV model allows a quantum circuit to produce output vectors of size equal to n raised to the power of n where n represents cutoff dimension and m, the number of qumodes. They are then translated as one-hot encoded labels, padded with an appropriate number of zeros. The total of eight different classifiers are built using 2,3,...,8 qumodes, based on the binary classifier architecture proposed in Continuous variable quantum neural networks. The displacement gate and the Kerr gate in the CV model allow for the bias addition and nonlinear activation components of classical neural networks to quantum. The classifiers are composed of a classical feedforward neural network, a quantum data encoding circuit, and a CV quantum neural network circuit. On a truncated MNIST dataset of 600 samples, a 4 qumode hybrid classifier achieves 100% training accuracy.
Around the half of the population in the world are affected by oral diseases, making it one of the most common health conditions. Quantum implementation in medical domain has revealed its potential and versatile applicability especially in medical imaging. This paper explores oral disease identification using hybrid quantum-classical neural networks (HQCNN) and quantum convolution neural networks (QCNN). Our work investigates the possibilities of quantum machine learning in processing complicated dental image data and the contributions it can make in oral healthcare. We implemented a hybrid and a pure QNN leveraging Qiskit framework and a whole dataset of annotated oral disease dataset. Our 8 qubit structured QCNN model and 2 qubit architecture of HQCNN model extract the image features by encoding the features into quantum circuits enabling more expressive demonstration employing fewer parameters. The final result showcases that QCNN and HQCNN perform better than CNNs in disease classification and promise better accuracy, generalization and computational efficiency. This experiment highlights a pioneering step in applying quantum inspired models for oral diagnostics, identifying promising avenues for improving oral healthcare worldwide.