Quantum in Biology, Quantum for Biology, and Biology for Quantum: Mapping the Evidence and the Road Ahead
Lea Gassab, Betony Adams, Yashine H. Goolam Hossen, Onur Pusuluk, Iannis K. Kominis, Özgür E. Müstecaplıoğlu, Francesco Petruccione, Travis J. A. Craddock
quant-phSubmitted Apr 30, 2026• Announced May 4, 2026• 0 citations
Quantum science and biology now intersect in three complementary directions: quantum in biology, quantum for biology, and biology for quantum. This review provides a structured narrative evidence map of that interface rather than an exhaustive catalogue or formal systematic review. For each topic, we ask what the mechanistic or technological claim is, which quantum resource is invoked, what the strongest experiments and models establish, which classical alternatives or engineering confounds remain competitive, and what decisive tests or benchmarks would most strongly change confidence. The most mature quantum-in-biology cases remain mechanistically constrained tunneling in some enzymatic hydrogen-transfer reactions and radical-pair spin chemistry as a viable framework for magnetoreception, whereas several higher-visibility topics remain suggestive but unresolved under physiological conditions. In quantum for biology, the central issue is whether quantum-enabled tools improve biological inference relative to strong classical baselines under realistic calibration, dose, throughput, and uncertainty constraints. In biology for quantum, the strongest claims arise when biomolecular structure or self-assembly measurably improves fabrication, integration, or robustness in quantum devices. Summary tables in the Appendix provide a compact cross-map view of the current evidence, major confounds, and the experiments or benchmarks most likely to discriminate between competing explanations.
Quantum science and biology now intersect in three complementary directions: quantum in biology, quantum for biology, and biology for quantum. This review provides a structured narrative evidence map of that interface rather than an exhaustive catalogue or formal systematic review. For each topic, we ask what the mechanistic or technological claim is, which quantum resource is invoked, what the strongest experiments and models establish, which classical alternatives or engineering confounds remain competitive, and what decisive tests or benchmarks would most strongly change confidence. The most mature quantum-in-biology cases remain mechanistically constrained tunneling in some enzymatic hydrogen-transfer reactions and radical-pair spin chemistry as a viable framework for magnetoreception, whereas several higher-visibility topics remain suggestive but unresolved under physiological conditions. In quantum for biology, the central issue is whether quantum-enabled tools improve biological inference relative to strong classical baselines under realistic calibration, dose, throughput, and uncertainty constraints. In biology for quantum, the strongest claims arise when biomolecular structure or self-assembly measurably improves fabrication, integration, or robustness in quantum devices. Summary tables in the Appendix provide a compact cross-map view of the current evidence, major confounds, and the experiments or benchmarks most likely to discriminate between competing explanations.
A study published on arXiv provides a structured narrative evidence map of the three complementary directions where quantum science and biology intersect: 'quantum in biology', 'quantum for biology', and 'biology for quantum'. It highlights hydrogen tunneling in enzymes and the radical-pair mechanism for magnetoreception as representative cases of quantum in biology. For quantum for biology, it analyzes how quantum sensing and imaging tools can improve biological inference. It also illuminates biology for quantum, which utilizes biomolecular self-assembly to enhance the performance of quantum devices, and presents a comprehensive benchmark to compare the current evidence and alternatives in each area. [Quantum Biology Society] As we enter the 21st century, the convergence of quantum physics and the life sciences is moving beyond mere curiosity to establish itself as a substantial scientific paradigm. A recent paper published on the preprint repository arXiv, titled "Quantum in Biology, Quantum for Biology, and Biology for Quantum: Mapping the Evidence and the Road Ahead," clearly defines the three core areas where these two disciplines intersect. It provides a first-of-its-kind structured narrative evidence map that compiles the technological claims and experimental evidence of each field. A multinational collaborative research team led by Professor Travis J. A. Craddock of the University of Waterloo in Canada and Professor Francesco Petruccione of Stellenbosch University in South Africa published this extensive review. ■ Quantum in Nature and Quantum Tools Illuminating Biology The first pillar presented in this paper, 'Quantum in biology', deals with instances where quantum mechanics directly intervenes in the natural biological phenomena of living organisms. The most scientifically mature evidence highlighted includes the quantum tunneling of hydrogen in enzyme catalysis and the radical-pair spin chemistry mechanism that enables magnetoreception in birds. The second pillar, 'Quantum for biology', explores the application of cutting-edge quantum tools to the life sciences. The core question analyzed in this area is whether quantum technologies—such as quantum computing, quantum sensing, and quantum imaging—can provide significantly more precise biological inference and resolution beyond existing classical baselines, even under realistic biological constraints. ■ Living Organisms as the Foundation for Quantum Technology The final third pillar, 'Biology for quantum', is an innovative approach that utilizes biological systems in reverse to develop quantum technologies. The paper evaluates that the strongest claims in this field arise when the sophisticated structure or self-assembly capabilities unique to biomolecules are used to measurably improve the fabrication, integration, and robustness of artificial quantum devices. This monumental review paper holds great significance as it presents a macroscopic roadmap for the emerging interdisciplinary field of quantum biology. It establishes a powerful benchmark that allows for the at-a-glance comparison and verification of the current evidence levels and competitive alternative models in each specific subfield. #QuantumBiology #QuantumScience #LifeScience #InterdisciplinaryConvergence #EvidenceMap #QuantumSensing #QuantumLifeScience #QuantumTools #FutureScience #KoreanSocietyOfQuantumBiology https://arxiv.org/abs/2605.00205
Abstract The lines separating Biology and Physics have started to blur in recent decades, leading to the emergence of the interdisciplinary field known as quantum Biology. This field looks into the possibility that basic quantum mechanical phenomena such as coherence, entanglement, tunneling, and superposition play crucial roles in biological processes that are beyond the scope of classical Physics. Biology has traditionally worked within the parameters of classical mechanics, presuming that delicate quantum effects cannot endure in the warm, humid, and cacophonous environments of living systems. But new findings in fields like photosynthesis, olfaction, avian magnetoreception, and enzyme catalysis indicate otherwise, suggesting that living things intentionally and possibly advantageously use quantum principles. From the earliest speculative theories to the most recent experimental confirmations, this book chapter methodically examines the evolution of quantum Biology. We investigate how the exceptionally high energy transfer efficiency in photosynthetic complexes particularly in the light-harvesting proteins of green sulfur bacteria and plants is supported by quantum coherence. The remarkable speed of proton transfers and enzymatic reactions during DNA replication is also investigated in relation to quantum tunneling. The chapter explores magnetoreception in migratory birds and suggests models in which sensitivity to Earth's geomagnetic field is made possible by radical pair mechanisms influenced by quantum entanglement. We also discuss the intriguing but controversial idea that quantum vibrations improve the human olfactory system's capacity for discrimination. In addition to examining particular occurrences, this research challenges more general theoretical models that seek to balance quantum mechanics with the decoherence commonly observed in biological settings. Recent developments in quantum information theory, biomimetic quantum technologies, and ultrafast spectroscopy are highlighted as essential instruments advancing empirical research. We also critically evaluate the field's methodological difficulties, the skepticism of overly optimistic interpretations, and the significant philosophical ramifications of acknowledging life as a quantum phenomenon. In conclusion, quantum Biology suggests that quantum effects are not uncommon aberrations but rather are an essential part of life, offering not only a fresh perspective for reinterpreting well-known biological processes but also the potential for a fundamental paradigm shift. Quantum biology has the potential to completely transform biotechnology, medicine, and our comprehension of consciousness and the origin of life as experimental methods advance. This chapter highlights the significance of interdisciplinary cooperation in order to completely comprehend the latest discoveries and possible future paths of quantum Biology, highlighting its revolutionary influence on our comprehension of life at the most basic levels. Key words: Quantum Biology, tunneling, avian magnetoreception, enzyme catalysis
Abstract Quantum biology has emerged as a frontier discipline, revealing that phenomena such as coherence, entanglement, and tunneling are not merely theoretical curiosities but functional components of living systems. This volume, Quantum Biology under ICQER, presents a unified framework for understanding these phenomena through the lens of the ICQER (Informational Constraints, Quantum Events, and Emergent Realities) paradigm. We propose that biological systems are fundamentally networks of informational constraints that channel, filter, and stabilize quantum events, enabling their propagation from molecular scales to emergent organismal behaviors. The work systematically examines how these constraint networks govern key biological processes, including photosynthetic energy transfer, enzymatic catalysis, magnetoreception, and neural cognition. Furthermore, we explore the evolutionary implications of quantum-informed constraints, demonstrating that natural selection acts not only on classical phenotypes but on the very architectures that harness quantum effects. By integrating molecular quantum dynamics with complex systems theory, this volume establishes ICQER as a predictive and unifying model for quantum biology. It redefines life as a quantum-constrained informational system and provides a roadmap for future research, with far-reaching implications for synthetic biology, bio-inspired technologies, and the fundamental understanding of life's informational architecture.
BACKGROUND: Key biological processes underlying health and disease-including electron transfer, redox regulation, and radical-mediated signaling-are fundamentally governed by quantum-mechanical principles. These processes are central to mitochondrial function, metabolism, and cellular signaling, yet their biomedical implications have remained difficult to address using classical computational approaches. RATIONALE: Recent advances in quantum computing, quantum sensing, and quantum machine learning enable direct simulation and measurement of quantum phenomena in biologically relevant systems. Hybrid quantum-classical algorithms, such as the Variational Quantum Eigensolver and Quantum Phase Estimation, now provide first-principles access to redox potentials, electronic couplings, and spin-dependent reactions that are directly linked to disease mechanisms. These developments establish the foundation for quantum biomedicine as a translational framework bridging molecular physics and clinical medicine. CONTENT: This review synthesizes current progress in the application of quantum technologies to biomedicine, emphasizing translational relevance. We discuss quantum-informed modeling of cancer metabolism and redox rewiring, protein misfolding in neurodegenerative diseases, immune and inflammatory signaling, infectious disease mechanisms, and drug discovery. We further propose a Quantum-Experimental-Clinical (QEC) pipeline that integrates quantum simulations with experimental validation and multi-omics clinical data, enabling mechanistic interpretation of disease phenotypes and identification of redox- and spin-sensitive therapeutic targets. CONCLUSION: Quantum biomedicine introduces a new mechanistic layer that links electronic-scale processes to clinical phenotypes. While current implementations are constrained by NISQ-era hardware, rapid advances in quantum algorithms and sensing technologies position quantum approaches as emerging tools in precision and translational medicine. Strategic integration of quantum methods with experimental and clinical workflows may accelerate biomarker discovery and therapeutic development. KEY POINTS: Quantum biomedicine redefines life as a dynamic equilibrium sustained by quantum coherence, tunnelling and redox resonance. Hybrid quantum-classical algorithms, such as VQE and QPE, enable first-principles modelling of redox and spin-dependent reactions with near-experimental accuracy. NISQ-era hardware supports proof-of-concept simulations of electron tunnelling and radical-pair dynamics, bridging computation with measurable biophysics. Integration of quantum simulations with spectroscopy and cryo-EM establishes a quantum-experimental-clinical (QEC) pipeline linking theory, experiment and medicine. Ethical, educational and governance frameworks are essential for equitable, transparent and sustainable implementation of quantum health technologies.
In the emerging field of quantum biology, we begin to see how biological systems exploit quantum mechanics as their efficiency and certain phenomena such as photosynthesis and enzymatic reactions cannot be explained only by classical physics. This paper will shortly review the foundations and axioms of quantum mechanics including wave particle duality, Heisenburg's uncertainty principle and the probabilistic interpretation of a wave function before exploring the first primary topic-quantum tunneling in enzymes. The paper will then provide deeper insights into quantum effects in photosynthesis including coherence, entanglement and the photoelectric effect. Additionally, quantum biology will have profound implications on the future of quantum technology. Leveraging the information scientists have gained about the quantum mechanical functions of biological systems, this paper will delve into the applications of this know-how in quantum technology.
Abstract Quantum technologies leverage the laws of quantum physics to achieve performance advantages in applications ranging from computing to communications and sensing. They have been proposed to have a range of applications in biological science. This includes better microscopes and biosensors, improved simulations of molecular processes, and new capabilities to control the behavior of biomolecules and chemical reactions. Quantum effects are also predicted, with much debate, to have functional benefits in biology, for instance, allowing more efficient energy transport and improving the rate of enzyme catalysis. Conversely, the robustness of biological systems to disorder from their environment has led to proposals to use them as components within quantum technologies, for instance as light sources for quantum communication systems. Together, this breadth of prospective applications at the interface of quantum and biological science suggests that quantum physics will play an important role in stimulating future biotechnological advances. This review aims to provide an overview of this emerging field of quantum biotechnology, introducing current capabilities, future prospects, and potential areas of impact. The review is written to be accessible to the non‐expert and focuses on the four key areas of quantum‐enabled sensing, quantum‐enabled imaging, quantum biomolecular control, and quantum effects in biology.