We introduce Simulated Bifurcation Quantum Annealing (SBQA), a quantum-inspired optimization algorithm that extends simulated bifurcation by incorporating inter-replica interactions to mimic quantum tunneling. SBQA retains the efficiency and parallelism of simulated bifurcation while improving performance on sparse and rugged energy landscapes. We derive its equations of motion, analyze parameter dependence, and propose a lightweight auto-tuning strategy. A comprehensive benchmarking study on both large-scale problems and smaller instances relevant for current quantum hardware shows that SBQA systematically improves on SBM in the sparse and rugged regimes where SBM is known to struggle, while remaining competitive and versatile across a diverse set of tested problem families. These results position SBQA as a practical quantum-inspired optimization heuristic and a stronger classical baseline for the sparse and rugged regimes studied here.
We introduce Simulated Bifurcation Quantum Annealing (SBQA), a quantum-inspired optimization algorithm that extends simulated bifurcation by incorporating inter-replica interactions to mimic quantum tunneling. SBQA retains the efficiency and parallelism of simulated bifurcation while improving performance on sparse and rugged energy landscapes. We derive its equations of motion, analyze parameter dependence, and propose a lightweight auto-tuning strategy. A comprehensive benchmarking study on both large-scale problems and smaller instances relevant for current quantum hardware shows that SBQA systematically improves on SBM in the sparse and rugged regimes where SBM is known to struggle, while remaining competitive and versatile across a diverse set of tested problem families. These results position SBQA as a practical quantum-inspired optimization heuristic and a stronger classical baseline for the sparse and rugged regimes studied here.
In a recent Letter [H. Munoz-Bauza and D. Lidar, Phys. Rev. Lett. 134, 160601 (2025)], quantum annealing was reported to exhibit a scaling advantage in approximately solving quadratic unconstrained binary optimization (QUBO) problems. Here, we revisit these findings by employing the simulated bifurcation machine (SBM), a nonlinear dynamical system that exploits chaotic behavior rather than thermal fluctuations. Our approach originates from quantum dynamics and shares key operational features with quantum annealing: (i) nearly parallel evolution and (ii) a well-defined relation between the energy gap, run-time, and solution quality. We obtain comparable or superior scaling, closing the reported quantum-classical gap. We further show that the small instances studied previously are insufficient to infer asymptotic behavior. Extending the analysis to larger problems reveals robust classical performance, indicating that current quantum annealers are unlikely to exhibit a clear scaling advantage over SBM-like solvers on quantum-annealing-correction-type QUBO problems under the run-time accounting studied here. Finally, we identify sparse problem classes where future quantum devices could achieve a genuine scaling advantage, once hardware overheads are mitigated.
Simulated Bifurcation (SB) algorithms, inspired by quantum annealing, can efficiently solve large-scale combinatorial optimization problems on classical hardware, often outperforming traditional approaches such as simulated annealing. However, their tendency to be trapped in local optima limits global solution quality. In this work, we introduce Tabu-Enhanced Simulated Bifurcation (TESB), an improved SB variant that incorporates a Tabu Search-inspired mechanism. By leveraging a dynamic penalty guided by early search history, TESB can naturally avoid revisiting suboptimal regions. On Max-Cut benchmarks, TESB achieves up to a three-order-of-magnitude reduction in Time-to-Solution compared to standard SB. When applied to particle track reconstruction in high-energy physics, TESB identifies lower-energy configurations on problems exceeding 100,000 spin variables, demonstrating enhanced scalability and performance across a wide range of combinatorial tasks. Combinatorial optimization is a challenging yet crucial class of problems, and Simulated Bifurcation (SB) is a promising approximate solver developed in recent years. The authors enhance SB with ideas from Tabu Search to improve its performance, demonstrating clear gains on Max-Cut and particle track reconstruction problems.
Abstract Two classes of quantum-annealing-inspired-algorithms (QAIA), namely different variants of simulated coherent Ising machine and simulated bifurcation, have been proposed for efficiently solving combinatorial optimization problems recently. In order to certify the superiority of these algorithms, standardized comparisons among them and against other physics-based algorithms are necessary. In this work, for Max-Cut problems up to 20,000 nodes, we benchmark QAIA against quantum annealing and other physics-based algorithms. We found that ballistic simulated bifurcation excelled for chimera and small-scale graphs, achieving nearly a 50-fold reduction in time-to-solution compared to quantum annealing. For large-scale graphs, discrete simulated bifurcation achieves the lowest time-to-target and outperforms D-Wave Advantage system when tasked with finding the maximum cut value in pegasus graphs. Our results suggest that QAIA represents a promising means for solving combinatorial optimization problems in practice, and can act as a natural baseline for competing quantum algorithms.
This study explores quantum-inspired optimization algorithms (QIOAs) as practical tools for solving constrained combinatorial problems on classical machines. We analyze tasks that can be formulated in Ising or QUBO forms and benchmark three representative approaches: Simulated Bifurcation (SB), Quantum-Inspired Particle Swarm Optimization (QPSO), and a tensor-network (TN) method. A unified evaluation protocol is introduced that captures solution quality, feasibility, runtime, energy consumption, parameter sensitivity, and scalability. To ensure reliable performance, we develop automated penalty-adjustment and schedule-calibration strategies. Experimental results across diverse benchmarks show that SB and TN together yield the best trade-offs between accuracy and runtime: SB is efficient on dense instances with moderate penalties and low energy use, while TN is advantageous for sparse or modular networks, especially on GPUs. QPSO is competitive in smoother landscapes but more sensitive to hyperparameters. By linking performance to structural properties such as spectral gaps and constraint activity, we provide guidance for selecting suitable algorithms. Overall, QIOAs emerge as effective intermediaries between existing classical heuristics and emerging quantum devices, supported by a reproducible, energy-aware evaluation framework.
Quantum annealing is a computational paradigm in which optimisation problems are mapped onto the energy landscape of an interacting quantum system and explored through its dynamical evolution. By continuously transforming a simple initial Hamiltonian into one whose ground state encodes the solution, the system traverses a complex landscape via a combination of quantum fluctuations, tunnelling processes, and dissipative dynamics. Unlike gate-based quantum computing, quantum annealing is a specialised and near-term approach aimed primarily at discrete optimisation and sampling tasks. While it is not expected to provide polynomial-time solutions to NP-hard problems in the worst case, it offers a physically motivated heuristic for navigating rugged energy landscapes that arise across science and engineering. Modern quantum annealers realise programmable spin systems with thousands of qubits, placing them among the largest controllable quantum devices currently available. As a result, their significance extends beyond optimisation: they also function as experimental platforms for studying non-equilibrium many-body quantum dynamics in regimes that are difficult to access using classical simulation. In this review we present an accessible introduction to the principles of quantum annealing, describe the main hardware platforms and algorithmic techniques, and analyse how tunnelling, spectral gaps, and open-system effects shape computational performance. We survey applications ranging from optimisation and machine learning to quantum simulation and many-body physics, and discuss the central challenges in benchmarking, scaling, and control. These perspectives position quantum annealing as a distinctive framework at the interface of optimisation, stochastic sampling, and programmable quantum dynamics, with a role that is complementary to both classical algorithms and gate-based quantum computing.
Molecular docking (MD) is a crucial task in drug design, which predicts the position, orientation, and conformation of the ligand when it is bound to a target protein. It can be interpreted as a combinatorial optimization problem, where quantum annealing (QA) has shown a promising advantage for solving combinatorial optimization. In this work, we propose a novel quantum molecular docking (QMD) approach based on a QA-inspired algorithm. We construct two binary encoding methods to efficiently discretize the degrees of freedom with an exponentially reduced number of bits and propose a smoothing filter to rescale the rugged objective function. We propose a new quantum-inspired algorithm, hopscotch simulated bifurcation (hSB), showing great advantages in optimizing over extremely rugged energy landscapes. This hSB can be applied to any formulation of an objective function under binary variables. An adaptive local continuous search is also introduced for further optimization of the discretized solution from hSB. Concerning the stability of docking, we propose a perturbation detection method to help rank the candidate poses. We demonstrate our approach on a typical data set. QMD has shown advantages over the search-based Autodock Vina and the deep-learning DIFFDOCK in both redocking and self-docking scenarios. These results indicate that quantum-inspired algorithms can be applied to solve practical problems in drug discovery even before quantum hardware become mature.