Qiboml: towards the orchestration of quantum-classical machine learning
Matteo Robbiati, Andrea Papaluca, Andrea Pasquale, Edoardo Pedicillo, Renato M. S. Farias, Alejandro Sopena, Mattia Robbiano, Ghaith Alramahi, Simone Bordoni, Alessandro Candido, Niccolò Laurora, Jogi Suda Neto, Yuanzheng Paul Tan, Michele Grossi, Stefano Carrazza
We present Qiboml, an open-source software library for orchestrating quantum and classical components in hybrid machine learning workflows. Building on Qibo's quantum computing capabilities and integrating with popular machine learning frameworks such as TensorFlow and PyTorch, Qiboml enables the construction of quantum and hybrid models that can run on a broad range of backends: (i) multi-threaded CPUs, GPUs, and multi-GPU systems for simulation with statevector or tensor network methods; (ii) quantum processing units, both on-premise and through cloud providers. In this paper, we showcase its functionalities, including diverse simulation options, noise-aware simulations, and real-time error mitigation and calibration.
We present Qiboml, an open-source software library for orchestrating quantum and classical components in hybrid machine learning workflows. Building on Qibo's quantum computing capabilities and integrating with popular machine learning frameworks such as TensorFlow and PyTorch, Qiboml enables the construction of quantum and hybrid models that can run on a broad range of backends: (i) multi-threaded CPUs, GPUs, and multi-GPU systems for simulation with statevector or tensor network methods; (ii) quantum processing units, both on-premise and through cloud providers. In this paper, we showcase its functionalities, including diverse simulation options, noise-aware simulations, and real-time error mitigation and calibration.
We introduce TensorFlow Quantum (TFQ), an open source library for the rapid prototyping of hybrid quantum-classical models for classical or quantum data. This framework offers high-level abstractions for the design and training of both discriminative and generative quantum models under TensorFlow and supports high-performance quantum circuit simulators. We provide an overview of the software architecture and building blocks through several examples and review the theory of hybrid quantum-classical neural networks. We illustrate TFQ functionalities via several basic applications including supervised learning for quantum classification, quantum control, simulating noisy quantum circuits, and quantum approximate optimization. Moreover, we demonstrate how one can apply TFQ to tackle advanced quantum learning tasks including meta-learning, layerwise learning, Hamiltonian learning, sampling thermal states, variational quantum eigensolvers, classification of quantum phase transitions, generative adversarial networks, and reinforcement learning. We hope this framework provides the necessary tools for the quantum computing and machine learning research communities to explore models of both natural and artificial quantum systems, and ultimately discover new quantum algorithms which could potentially yield a quantum advantage.
Among notable applications, quantum machine learning (QML) is a promising task that combines quantum computing with machine learning, cited for various types of complex computational problems. This chapter briefly summarizes the frameworks, software platforms, and toolchains currently available for implementing, simulating, and executing hybrid quantum–classical learning algorithms. Major frameworks (e.g., Qiskit Machine Learning, PennyLane, TensorFlow Quantum, and the PyTorch-based toolsets) are analyzed in detail based on their architectural design, functionality, and integration capabilities. They have several key features, such as variational quantum circuits, parameterized quantum gates, automatic differentiation capabilities, and easy integration into a classical deep learning ecosystem. The chapter groups together ongoing research in different architectural paradigms, practical usability aspects, and empirical performance tests. Additionally, it explores aspects of scalability, adaptability to hardware, noise resistance, and reproducibility. The results bring to light elements of the design of trade-offs for creating robust and efficient toolchains for QML, a QML best practice, and guidance for future QML design.
Quantum machine learning (QML) has emerged as a promising field, combining the power of quantum computing with classical machine learning techniques to solve complex computational tasks. As the demand for efficient quantum simulations grows, multiple QML frameworks, including PennyLane, Qiskit, and TensorFlow Quantum (TFQ), have been developed to facilitate hybrid quantum-classical computations. This study aims to evaluate and compare the performance of three leading QML frameworks PennyLane, Qiskit, and TensorFlow Quantum in simulating quantum machine learning models, focusing on accuracy, execution time, and noise tolerance. The study examined three leading quantum machine learning (QML) frameworks PennyLane (v0.24), Qiskit (v0.43.2), and TensorFlow Quantum (TFQ, v0.7) each tested on a 64-bit Ubuntu Linux system with an Intel Core i7 processor, 32 GB RAM, and NVIDIA GeForce RTX 3080 GPU. Quantum algorithms like variational quantum circuits (VQCs) and quantum support vector machines (QSVMs) were simulated using these frameworks. Various quantum gates, including Pauli-X, Y, Z, Hadamard, CNOT, and Rotation gates (Rx, Ry, Rz), were used for parameter optimization and quantum superposition. The Iris and MNIST datasets were adapted for quantum encoding using Amplitude and Angle Encoding for binary classification tasks. Simulations were run on classical computers, while select circuits were executed on IBM Quantum’s Falcon r5.11 processor to compare hardware performance. PennyLane achieved the highest accuracy (92%) in quantum simulations, excelling in hybrid quantum-classical model integration. TensorFlow Quantum provided the fastest execution time, especially in classical simulations, making it suitable for rapid prototyping. Qiskit produced deeper quantum circuits but had higher error rates (6%) on real quantum hardware, highlighting noise and decoherence effects. The VQC models optimized by stochastic gradient descent (SGD) showed significant improvements in model performance, and QSVMs effectively classified both linearly separable and non-separable datasets, demonstrating the potential of quantum algorithms over classical approaches. Statistical analysis confirmed the significance of the results (p < 0.05). PennyLane is the most robust framework for hybrid quantum-classical models, while TensorFlow Quantum is suited for rapid prototyping. Qiskit, despite longer execution times, excels in hardware implementation. The choice of framework should align with the specific needs of quantum machine learning tasks.
Hybrid quantum-classical workflows combine quantum processing units (QPUs) with classical hardware to address computational tasks that are challenging or infeasible for conventional systems alone. Coordinating these heterogeneous resources at scale demands robust orchestration, reproducibility, and observability. Even in the presence of fault-tolerant quantum devices, quantum computing will continue to operate within a broader hybrid ecosystem, where classical infrastructure plays a central role in task scheduling, data movement, error mitigation, and large-scale workflow coordination.
In this work, we present a cloud-native framework for managing hybrid quantum-HPC pipelines using Kubernetes, Argo Workflows, and Kueue. Our system unifies CPUs, GPUs, and QPUs under a single orchestration layer, enabling multi-stage workflows with dynamic, resource-aware scheduling. We demonstrate the framework with a proof-of-concept implementation of distributed quantum circuit cutting, showcasing execution across heterogeneous nodes and integration of classical and quantum tasks. This approach highlights the potential for scalable, reproducible, and flexible hybrid quantum-classical computing in cloud-native environments.
Objective: To synthesize the state of the art on how quantum computing (QC) and artificial intelligence (AI) intersect, including algorithmic foundations, software/hardware stacks, empirical evidence of advantage, applications, and open challenges. Methods: We executed a structured search (2019 – 20th August 2025) across major journals (Nature portfolio, APS/PR, Elsevier), arXiv, and official framework documentation (Qiskit, Cirq/TFQ, PennyLane; AWS Braket; NVIDIA CUDA-Q). We included peer‑reviewed studies, comprehensive surveys, and official docs; we excluded opinion pieces and non-reproducible claims. Results: The field converges on hybrid quantum‑classical workflows with two dominant AI families: (i) quantum kernel methods and (ii) variational circuits/QNNs. Trainability remains a core challenge (barren plateaus and noise), with mitigation strategies advancing (local costs, layerwise training, engineered dissipation, learned decoders). Frameworks and cloud orchestrators now support end‑to‑end hybrid training. Empirical “utility” demonstrations in physics‑inspired tasks exist, while domain‑level advantage in mainstream ML is unproven and data‑dependent. Conclusions: QC‑AI integration is maturing into reproducible hybrid stacks. Near‑term value lies in quantum kernels with tailored feature maps, physics‑regularized QNNs, simulator‑accelerated pipelines, and AI‑for‑QC (calibration/decoding). Broad ML advantage awaits lower‑noise hardware and quantum‑friendly data embeddings.
We introduce DeepQuantum, an open-source, PyTorch-based software platform for quantum machine learning and photonic quantum computing. This AI-enhanced framework enables efficient design and execution of hybrid quantum-classical models and variational quantum algorithms on both CPUs and GPUs. For photonic quantum computing, DeepQuantum implements Fock, Gaussian, and Bosonic backends, catering to different simulation needs. To our knowledge, it is the first framework to realize closed-loop integration of three paradigms of quantum computing, namely quantum circuits, photonic quantum circuits, and measurement-based quantum computing, thereby enabling robust support for both specialized and universal photonic quantum algorithm design. Furthermore, DeepQuantum supports large-scale simulations based on tensor network techniques and a distributed parallel computing architecture. We demonstrate these capabilities through comprehensive benchmarks and illustrative examples. With its unique features, DeepQuantum is intended to be a powerful platform for both AI for Quantum and Quantum for AI.