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arXiv:2505.10794

Quantifying the advantage of quantum correlation microscopy using arrays of single-photon detectors

Jaret J. Vasquez-Lozano, Qiang Sun, Shuo Li, Andrew D. Greentree

Published May 16, 2025• 0 citations
arXivHTMLPDF

Abstract

Quantum correlation microscopy is an emerging technique for improving optical resolution. By taking advantage of the quantum statistics from single-photon fluorophores, more information about the emitters (including number and location) is obtained compared with classical microscopy. Although it is known that the resolution can be improved by increasing detector numbers, as well as using quantum correlation, the quantitative relationship between these two approaches is not immediately clear. Here we explore widefield quantum correlation microscopy using arrays of single-photon detectors. We explicitly compare the use of $N$ detectors used in photon counting mode vs $N/2$ detectors used to measure quantum correlations. i.e., where there are $N/2$ Hanbury Brown and Twiss systems, using the same $N$ detectors, on randomly generated two-emitter systems. We find regimes where $N/2$ Hanbury Brown and Twiss detectors provide improved localisation compared to $N$ photon counting detectors, as a function of emitter position and number of photons sampled.

DOI
10.48550/arxiv.2505.10794

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The classical optical diffraction limit can be overcome by exploiting the quantum properties of light in several theoretical studies; however, they mostly rely on an entangled light source. Recent experiments have demonstrated that quantum properties are preserved in many fluorophores, which makes it possible to add a new dimension of information for super-resolution fluorescence imaging. Here, we developed a statistical quantum coherence model for fluorescence emitters and proposed a new super-resolution method using fluorescence quantum coherence in fluorescence microscopy. In this study, by exploiting a single-photon avalanche detector (SPAD) array with a time-correlated single-photon-counting technique to perform spatial-temporal photon statistics of fluorescence coherence, the subdiffraction-limited spatial separation of emitters is obtained from the determined coherence. We numerically demonstrate an example of two-photon interference from two common fluorophores using an achievable experimental procedure. Our model provides a bridge between the macroscopic partial coherence theory and the microscopic dephasing and spectral diffusion mechanics of emitters. By fully taking advantage of the spatial-temporal fluctuations of the emitted photons as well as coherence, our quantum-enhanced imaging method has the significant potential to improve the resolution of fluorescence microscopy even when the detected signals are weak.