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arXiv:1810.01712 · Physical Review A

Quantum multilateration: Subdiffraction emitter pair localization via three spatially separate Hanbury Brown and Twiss measurements

Josef G. Worboys, Daniel W. Drumm, Andrew D. Greentree

Published Jan 10, 2020• 11 citations
arXivHTMLPDF

Abstract

Typically, optical microscopy uses the wavelike properties of light to image a scene. However, photon arrival times provide more information about emitter properties than the classical intensity alone. Here we show that the Hanbury Brown and Twiss experiment (second-order correlation function) measures the relative brightness of two single-photon emitters. By combining the total number of detected photons with the zero-lag value of the correlation function, the positions and relative brightness of two emitters in two dimensions can be resolved from only three measurement positions: trilateration. This result is impossible to achieve on the basis of classical intensity measurements alone and represents a minimal demonstration of the advantage gained using quantum measurements over conventional classical microscopy. The effective point-spread function for imaging scales approximately as the inverse square root of the acquisition time.

DOI
10.1103/physreva.101.013810

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Typically, optical microscopy uses the wavelike properties of light to image a scene. However, photon arrival times provide more information about emitter properties than the classical intensity alone. Here we show that the Hanbury Brown and Twiss experiment (second-order correlation function) measures the relative brightness of two single-photon emitters. By combining the total number of detected photons with the zero-lag value of the correlation function, the positions and relative brightness of two emitters in two dimensions can be resolved from only three measurement positions: trilateration. This result is impossible to achieve on the basis of classical intensity measurements alone and represents a minimal demonstration of the advantage gained using quantum measurements over conventional classical microscopy. The effective point-spread function for imaging scales approximately as the inverse square root of the acquisition time.
Quantum correlation microscopy is an emerging technique for improving optical resolution. By taking advantage of the quantum statistics from single-photon fluorophores, more information about the emitters (including number and location) is obtained compared with classical microscopy. Although it is known that the resolution can be improved by increasing detector numbers, as well as using quantum correlation, the quantitative relationship between these two approaches is not immediately clear. Here we explore widefield quantum correlation microscopy using arrays of single-photon detectors. We explicitly compare the use of NNN detectors used in photon counting mode vs N/2N/2N/2 detectors used to measure quantum correlations. i.e., where there are N/2N/2N/2 Hanbury Brown and Twiss systems, using the same NNN detectors, on randomly generated two-emitter systems. We find regimes where N/2N/2N/2 Hanbury Brown and Twiss detectors provide improved localisation compared to NNN photon counting detectors, as a function of emitter position and number of photons sampled.
Correlation microscopy is an emerging technique for improving optical resolution. By taking advantage of the photon statistics from single-photon fluorophores, more information about the emitters (including number and location) is obtained compared with classical microscopy. Although it is known that the resolution can be improved by increasing detector numbers, as well as using photon correlations, the quantitative relationship between these two approaches is not immediately clear. Here we explore widefield photon correlation microscopy using arrays of single-photon detectors. We explicitly compare the use of N detectors used in photon counting mode vs N/2 detectors used to measure photon correlations. i.e., where there are N/2 Hanbury Brown and Twiss systems, using the same N detectors, on randomly generated two-emitter systems and triangular three-emitter systems. We find regimes where N/2 Hanbury Brown and Twiss detectors provide improved localisation compared to N photon counting detectors, as a function of emitter position and number of photons sampled.
Achieving higher resolution scales in optical microscopy allow a more rigorous investigation into the detailed components of cell systems. This higher resolution is typically achieved through super-resolution techniques utilizing methods inside the wave-like nature of light such as point spread function shaping and fluorophore switching. We wish to leverage both particle-like and wave-like natures of light to make a diffraction unlimited protocol. Our protocol uses the well known Hanbury Brown and Twiss (HBT) apparatus in combination with a customized second-order cross-correlation protocol. By performing least squares fitting of the HBT and intensity measurements we obtain diffraction unlimited localization for two particles of unknown relative brightness from few measurement locations. Our results show super-resolution enhancement by an order of magnitude after 5000 detection lifetimes.
Abstract The localisation of fluorophores is an important aspect of determining the biological function of cellular systems. Quantum correlation microscopy (QCM) is a promising technique for providing diffraction unlimited emitter localisation that can be used with either confocal or widefield modalities. However, so far, QCM has not been applied to three dimensional localisation problems. Here we show that QCM provides diffraction-unlimited three-dimensional localisation for two emitters within a single diffraction-limited spot. By introducing a two-stage maximum likelihood estimator, our modelling shows that the localisation precision scales as 1 / t where t is the total detection time. Diffraction unlimited localisation is achieved using both intensity and photon correlation from Hanbury Brown and Twiss measurements at as few as four measurement locations. We also compare the results of (MC) simulations with the Cramér–Rao lower bound.
The Hanbury Brown–Twiss (HBT) interferometer, which is used to measure the correlation of two photons or two light beams, has played a crucial role in quantum optics and quantum information. We propose a generalized HBT interferometer, which is able to measure the correlation of photons or light beams up to eight in a single experimental run. With an improved time correlated single-photon counting (TCSPC) algorithm, two-, three-, and four-photon coincidence counts, and the degree of fifth-order coherence of pseudothermal light are measured with a data collection time of 60 s. The generalized HBT interferometer can be used to measure the correlation of two multi-photon detection events by simulating photon number resolving detectors with multiple single-photon detectors. The generalized HBT interferometer and improved TCSPC algorithm provide a versatile framework for studying multi-photon correlations and interference, which is helpful to understand the physics of multi-photon interference and may find applications in fluorescence lifetime imaging and other techniques using TCSPC.