In emerging quantum-classical integration applications, the classical time cost-especially from compilation and protocol-level communication often exceeds the execution time of quantum circuits themselves, posing a severe bottleneck to practical deployment. To overcome these limitations, QPanda3 has been extensively optimized as a high-performance quantum programming framework tailored for the demands of the NISQ era and quantum-classical hybrid workflows. It features optimized circuit compilation, a custom binary instruction stream (OriginBIS), and hardware-aware execution strategies to significantly reduce latency and communication overhead. OriginBIS achieves up to 86.9$\times$ faster encoding and 35.6$\times$ faster decoding than OpenQASM 2.0, addressing critical bottlenecks in hybrid quantum systems. Benchmarks show 10.7$\times$ compilation speedup and up to 597$\times$ acceleration in compiling large-scale circuits (e.g., a 118-qubit W-state) compared to Qiskit. n high-performance simulation, QPanda3 excels in variational quantum algorithms, achieving up to 26$\times$ faster gradient computation than Qiskit, with minimal time-complexity growth across circuit depths. These capabilities make QPanda3 well-suited for scalable quantum algorithm development in finance, materials science, and combinatorial optimization, while supporting industrial deployment and cloud-based execution in quantum-classical hybrid computing scenarios.
In emerging quantum-classical integration applications, the classical time cost-especially from compilation and protocol-level communication often exceeds the execution time of quantum circuits themselves, posing a severe bottleneck to practical deployment. To overcome these limitations, QPanda3 has been extensively optimized as a high-performance quantum programming framework tailored for the demands of the NISQ era and quantum-classical hybrid workflows. It features optimized circuit compilation, a custom binary instruction stream (OriginBIS), and hardware-aware execution strategies to significantly reduce latency and communication overhead. OriginBIS achieves up to 86.9× faster encoding and 35.6× faster decoding than OpenQASM 2.0, addressing critical bottlenecks in hybrid quantum systems. Benchmarks show 10.7× compilation speedup and up to 597× acceleration in compiling large-scale circuits (e.g., a 118-qubit W-state) compared to Qiskit. n high-performance simulation, QPanda3 excels in variational quantum algorithms, achieving up to 26× faster gradient computation than Qiskit, with minimal time-complexity growth across circuit depths. These capabilities make QPanda3 well-suited for scalable quantum algorithm development in finance, materials science, and combinatorial optimization, while supporting industrial deployment and cloud-based execution in quantum-classical hybrid computing scenarios.
Quantum computing promises computational speedups over classical approaches for certain problem classes; however, in near term quantum and classical hybrid workflows, the overall performance is often constrained by classical processing overhead. The time cost associated with circuit compilation, which includes gate decomposition, topology aware qubit mapping, and depth optimization, together with protocol level communication such as circuit transfer and measurement result exchange, frequently exceeds the actual quantum circuit execution time and has become a critical bottleneck to practical deployment. In this paper, we propose QPanda 3.0, a high performance quantum programming framework optimized to accelerate the classical compilation path that underpins NISQ era hybrid integration. Leveraging an optimized compilation pipeline, a custom binary instruction stream (OriginBIS), and hardware aware execution strategies, QPanda 3.0 achieves up to 86.9 × faster encoding and 35.6 × faster decoding than OpenQASM 2.0, as well as an average 10.7 × compilation speedup over Qiskit across the four evaluated connectivity topologies, with a peak speedup of 597 × for a 118-qubit W-state circuit on a square topology. These capabilities enable the development of scalable quantum algorithms across various domains, including finance, materials science, and combinatorial optimization, supporting both industrial deployment and cloud based execution in hybrid computing environments.
To address the urgent need in the NISQ era for high-performance, scalable quantum compilers and to advance the integration of classical and quantum computing, we present QLLVM, an advanced Quantum-Classical co-compilation framework built on LLVM. To our knowledge, QLLVM delivers an end-to-end, LLVM-based compilation workflow that unifies the build of classical high-performance programs, including CUDA, MPI, and C++, together with quantum programs into a single executable. For quantum program compilation, QLLVM adopts a three-stage design: high-level optimizations are implemented in the MLIR Quantum dialect and then lowered to QIR, an LLVM IR-based representation, for low-level optimization and hardware mapping. Its extensible architecture and seamless interoperability with classical high-performance computing provide an efficient, flexible, industrial-grade compilation infrastructure for future quantum software development. Experimental results show that, on the MQTBench benchmark suite, QLLVM reduces circuit depth and gate counts compared with state-of-the-art compilers and demonstrates clear advantages in compiling hybrid classical-quantum programs.
Hybrid quantum-high performance computing (Q-HPC) workflows are emerging as a key strategy for running quantum applications at scale in current noisy intermediate-scale quantum (NISQ) devices. These workflows must operate seamlessly across diverse simulators and hardware backends since no single simulator offers the best performance for every circuit type. Simulation efficiency depends strongly on circuit structure, entanglement, and depth, making a flexible and backend-agnostic execution model essential for fair benchmarking, informed platform selection, and ultimately the identification of quantum advantage opportunities. In this work, we extend the Quantum Framework (QFw), a modular and HPC-aware orchestration layer, to integrate multiple local backends (Qiskit Aer, NWQ-Sim, QTensor, and TN-QVM) and a cloud-based quantum backend (IonQ) under a unified interface. Using this integration, we execute a number of non-variational as well as variational workloads. The results highlight workload-specific backend advantages: while Qiskit Aer’s matrix product state excels for large Ising models, NWQ-Sim not only leads on large-scale entanglement and Hamiltonian but also shows the benefits of concurrent subproblem execution in a distributed manner for optimization problems. These findings demonstrate that simulator-agnostic, HPC-aware orchestration is a practical path toward scalable, reproducible, and portable Q-HPC ecosystems, thereby accelerating progress toward demonstrating quantum advantage.
Introduction Hybrid Variational Quantum Algorithms (VQAs) present a highly viable pathway to near-term quantum utility; however, their performance is fundamentally bottlenecked by classical-quantum communication latency in Quantumas-a-Service (QaaS) environments. Methods This paper proposes an optimized classical-quantum orchestration architecture designed to minimize cloud-induced latency and maximize Quantum Processing Unit (QPU) active compute time. By implementing edge-colocated classical optimizers alongside batched parameter-shift gradient evaluations, the system circumvents stateless cloud API barriers. Results Benchmarking across parameterized quantum circuits ranging from 15 to 50 qubits demonstrates an 84% reduction in network-induced QPU idle time. The framework yields a 3.2 × speedup in overall convergence time for the Quantum Approximate Optimization Algorithm (QAOA) and up to a 98% reduction in classical API call overhead compared to standard RESTful QaaS execution models. Discussion These quantitative findings demonstrate that tightly coupled hybrid co-processing, physically adjacent to the control electronics, is critical for extending the computational bound of Noisy Intermediate-Scale Quantum (NISQ) devices.
This paper presents a hybrid computational framework that integrates classical and quantum optimization techniques to improve the efficiency of Huffman encoding and string-matching algorithms.On the classical side, performance is enhanced through SIMD (Single Instruction, Multiple Data) parallelism, bitlevel operations, and cache-aware data structures.On the quantum side, we investigate Grover-based string search using amplitude amplification, approximate reflection operators, and entropy-aware circuit design tailored for Noisy Intermediate-Scale Quantum (NISQ) constraints.The primary contribution of this work is a hybrid visualization framework that synchronizes classical algorithmic flowcharts with real-time quantum circuit representations, enabling unified debugging, execution tracing, and performance analysis across both domains.Experimental evaluations conducted using optimized classical implementations and quantum simulators with noise models demonstrate up to a 65% reduction in runtime for quantum-enhanced string search and over a 30% speedup in classical SIMD-accelerated Huffman encoding.The proposed quantum optimizations maintain an accuracy above 97% while reducing circuit depth, indicating practical feasibility under current NISQ limitations.By improving both algorithmic performance and developer interpretability, this hybrid framework serves as an effective tool for algorithm design, analysis, and education.The results highlight the potential of tightly coupled classical-quantum workflows and motivate further research into scalable, NISQ-compatible hybrid algorithm development.
The Noisy Intermediate-Scale Quantum (NISQ) era, defined by qubit counts in the hundreds and gate error rates that preclude long coherence times, imposes severe constraints on purely quantum computation. The central problem is that achieving practical quantum advantage for real-world tasks must overcome these hardware limitations, yet fault-tolerant quantum computers with full error correction remain years away. To address this, we present a systematic survey of hybrid classical-quantum computing models, in which classical high-performance resources orchestrate the workflow, perform iterative optimization, and apply error mitigation to noisy quantum processing units. Our review encompasses variational quantum algorithms, such as the variational quantum eigensolver and quantum approximate optimization algorithm; classical optimizers tailored for noisy quantum landscapes; error mitigation techniques including zero-noise extrapolation and probabilistic error cancellation; and circuit knitting that partitions large circuits across small QPUs. We find that these hybrid architectures have already demonstrated domain-specific utility in quantum chemistry for molecular ground-state estimation, in logistics and finance for combinatorial optimization, and in machine learning for generative and recommendation models. Notably, they often surpass purely classical or purely quantum approaches on carefully chosen benchmarks. The evidence indicates that hybrid classical-quantum systems are not a temporary stopgap but a durable paradigm. Their role will persist into the early fault-tolerant era, where small, logical qubits will similarly require classical coordination. Consequently, the field urgently demands the establishment of standardized hybrid performance benchmarks, the maturation of robust quantum-classical middleware capable of efficient transpiration and execution management, and holistic co-design frameworks that seamlessly integrate hardware constraints, software stack layers, and application-specific requirements from the outset.