Quantum Machine Learning (QML) offers significant potential for complex tasks like genome sequence classification, but quantum noise on Noisy Intermediate-Scale Quantum (NISQ) devices poses practical challenges. This study systematically evaluates how various quantum noise models including dephasing, amplitude damping, depolarizing, thermal noise, bit-flip, and phase-flip affect key QML algorithms (QSVC, Peg-QSVC, QNN, VQC) and feature mapping techniques (ZFeatureMap, ZZFeatureMap, and PauliFeatureMap). Results indicate that QSVC is notably robust under noise, whereas Peg-QSVC and QNN are more sensitive, particularly to depolarizing and amplitude-damping noise. The PauliFeatureMap is especially vulnerable, highlighting difficulties in maintaining accurate classification under noisy conditions. These findings underscore the critical importance of feature map selection and noise mitigation strategies in optimizing QML for genomic classification, with promising implications for personalized medicine.
Quantum Machine Learning (QML) offers significant potential for complex tasks like genome sequence classification, but quantum noise on Noisy Intermediate-Scale Quantum (NISQ) devices poses practical challenges. This study systematically evaluates how various quantum noise models including dephasing, amplitude damping, depolarizing, thermal noise, bit-flip, and phase-flip affect key QML algorithms (QSVC, Peg-QSVC, QNN, VQC) and feature mapping techniques (ZFeatureMap, ZZFeatureMap, and PauliFeatureMap). Results indicate that QSVC is notably robust under noise, whereas Peg-QSVC and QNN are more sensitive, particularly to depolarizing and amplitude-damping noise. The PauliFeatureMap is especially vulnerable, highlighting difficulties in maintaining accurate classification under noisy conditions. These findings underscore the critical importance of feature map selection and noise mitigation strategies in optimizing QML for genomic classification, with promising implications for personalized medicine.
Quantum Machine Learning (QML) continues to evolve, unlocking new opportunities for diverse applications. In this study, we investigate and evaluate the applicability of QML models for binary classification of genome sequence data by employing various feature mapping techniques. We present an open-source, independent Qiskit-based implementation to conduct experiments on a benchmark genomic dataset. Our simulations reveal that the interplay between feature mapping techniques and QML algorithms significantly influences performance. Notably, the Pegasos Quantum Support Vector Classifier (Pegasos-QSVC) exhibits high sensitivity, particularly excelling in recall metrics, while Quantum Neural Networks (QNN) achieve the highest training accuracy across all feature maps. However, the pronounced variability in classifier performance, dependent on feature mapping, highlights the risk of overfitting to localized output distributions in certain scenarios. This work underscores the transformative potential of QML for genomic data classification while emphasizing the need for continued advancements to enhance the robustness and accuracy of these methodologies.
Genomic data analysis is essential for personalized medicine, disease diagnostics, and understanding evolutionary biology, yet remains challenging due to high dimensionality and sequence complexity. Quantum Machine Learning (QML) offers promising computational advantages for scalable genomic analysis. We explore QML modeling for genomic sequence classification using 100,000 sequences from two transcript classes. Our new framework incorporates PCA dimensionality reduction and evaluates multiple quantum feature maps (ZFeatureMap, ZZFeatureMap, PauliFeatureMap). Results show Pegasos-QSVC achieving 99.12% recall and 67.41% F1 score, while QNNs reach 54.38% training accuracy. Performance varies across feature maps, with some models exhibiting overfitting.
The limited supply of qubits and significant quantum noise impose limitations on the capability of quantum algorithms in the Noisy Intermediate-Scale Quantum (NISQ) era. NISQ devices have a variety of applications, such as Variational Quantum Circuit (VQC), which provides answers to difficult optimization and machine learning problems. This paper presents a thorough investigation of quantum variational classification in the NISQ context, with a focus on comprehending noise's impact on various feature maps and VQCs. We evaluate the effectiveness of quantum classifiers using a variety of datasets, ranging from straightforward binary classification problems to more complex tasks. Our results reveal the critical role that feature maps and variational circuit selection play in mitigating the effect of noise, identifying specific quantum circuit designs that exhibit robustness even in noisy situations. In order to highlight the potential of quantum machine learning in solving complex problems within in the NISQ setting, this study emphasizes the delicate interaction between feature map selection, variational circuit design, dataset complexity, and quantum noise.
The rapid advancement of Noisy Intermediate-Scale Quantum (NISQ) devices necessitates a systematic evaluation of quantum machine learning (QML) algorithms to determine their feasibility for near-term applications. This study aims to benchmark the Variational Quantum Classifier (VQC)and the Quantum Kernel Support Vector Machine (QSVM) under realistic noise conditions modeled using Qiskit Aer. The primary objective is to investigate the impact of depolarizing and amplitude damping noise on the classification performance of these algorithms. Using the Iris binary classification task, we simulated four noise levels (0, 0.01, 0.05, 0.1) and evaluated accuracy across 1024 measurement shots. Results show that QSVM achieves superior accuracy (70%) under ideal and lownoise conditions, while VQC exhibits higher resilience at moderate noise (50% at 0.05 noise level) due to its adaptive Variational parameters. At higher noise levels (0.1), both models converge to ~35–40% accuracy, indicating significant degradation. These findings provide actionable insights for algorithm selection on NISQ hardware, with VQC favored for moderately noisy devices and QSVM preferable for low-noise or error-mitigated systems. The study concludes by highlighting the need for noise-aware ansatz design and error mitigation techniques to enhance QML performance in NISQ regimes.
In current noisy intermediate-scale quantum (NISQ) devices, hybrid quantum neural networks (HQNNs) offer a promising solution, combining the strengths of classical machine learning with quantum computing capabilities. However, the performance of these networks can be significantly affected by the quantum noise inherent in NISQ devices. In this paper, we conduct an extensive comparative analysis of various HQNN algorithms, namely Quantum Convolution Neural Network (QCNN), Quanvolutional Neural Network (QuanNN), and Quantum Transfer Learning (QTL), for image classification tasks. We evaluate the performance of each algorithm across quantum circuits with different entangling structures, variations in layer count, and optimal placement in the architecture. Subsequently, we select the highest-performing architectures and assess their robustness against noise influence by introducing quantum gate noise through Phase Flip, Bit Flip, Phase Damping, Amplitude Damping, and the Depolarization Channel. Our results reveal that the top-performing models exhibit varying resilience to different noise channels. However, in most scenarios, the QuanNN demonstrates greater robustness across various quantum noise channels, consistently outperforming other models. This highlights the importance of tailoring model selection to specific noise environments in NISQ devices.
In current noisy intermediate-scale quantum (NISQ) devices, hybrid quantum neural networks (HQNNs) offer a promising solution, combining the strengths of classical machine learning with quantum computing capabilities. However, the performance of these networks can be significantly affected by the quantum noise inherent in NISQ devices. In this paper, we conduct an extensive comparative analysis of various HQNN algorithms, namely Quantum Convolution Neural Network (QCNN), Quanvolutional Neural Network (QuanNN), and Quantum Transfer Learning (QTL), for image classification tasks. We evaluate the performance of each algorithm across quantum circuits with different entangling structures, variations in layer count, and optimal placement in the architecture. Subsequently, we select the highest-performing architectures and assess their robustness against noise influence by introducing quantum gate noise through Phase Flip, Bit Flip, Phase Damping, Amplitude Damping, and the Depolarizing Channel. Our results reveal that the top-performing models exhibit varying resilience to different noise gates. However, in most scenarios, the QuanNN demonstrates greater robustness across various quantum noise channels, consistently outperforming other models. This highlights the importance of tailoring model selection to specific noise environments in NISQ devices.