In this work, we are introducing a Quantum-Classical Bayesian Neural Network (QCBNN) that is capable to perform uncertainty-aware classification of classical medical dataset. This model is a symbiosis of a classical Convolutional NN that performs ultra-sound image processing and a quantum circuit that generates its stochastic weights, within a Bayesian learning framework. To test the utility of this idea for the possible future deployment in the medical sector we track multiple behavioral metrics that capture both predictive performance as well as model’s uncertainty. It is our ambition to create a hybrid model that is capable to classify samples in a more uncertainty aware fashion, which will advance the trustworthiness of these models and thus bring us step closer to utilizing them in the industry. We test multiple setups for quantum circuit for this task, and our best architectures display bigger uncertainty gap between correctly and incorrectly identified samples than its classical benchmark at an expense of a slight drop in predictive performance. The innovation of this paper is two-fold: (1) combining of different approaches that allow the stochastic weights from the quantum circuit to be continues thus allowing the model to classify application-driven dataset; (2) studying architectural features of quantum circuit that make-or-break these models, which pave the way into further investigation of more informed architectural designs.
In this work, we are introducing a Quantum-Classical Bayesian Neural Network (QCBNN) that is capable to perform uncertainty-aware classification of classical medical dataset. This model is a symbiosis of a classical Convolutional NN that performs ultra-sound image processing and a quantum circuit that generates its stochastic weights, within a Bayesian learning framework. To test the utility of this idea for the possible future deployment in the medical sector we track multiple behavioral metrics that capture both predictive performance as well as model’s uncertainty. It is our ambition to create a hybrid model that is capable to classify samples in a more uncertainty aware fashion, which will advance the trustworthiness of these models and thus bring us step closer to utilizing them in the industry. We test multiple setups for quantum circuit for this task, and our best architectures display bigger uncertainty gap between correctly and incorrectly identified samples than its classical benchmark at an expense of a slight drop in predictive performance. The innovation of this paper is two-fold: (1) combining of different approaches that allow the stochastic weights from the quantum circuit to be continues thus allowing the model to classify application-driven dataset; (2) studying architectural features of quantum circuit that make-or-break these models, which pave the way into further investigation of more informed architectural designs.
Quantum circuits and classical convolutional neural networks are used in hybrid quantum-classical neural networks (HQCNNs) to classify medical images, particularly MRI and CT scans for bone cancer diagnosis. This review covers cutting-edge hybrid designs for parallel quantum circuit tumour detection, illness diagnosis, and anatomical pattern identification. Recent research reveal methodological trends, performance benchmarks, and architectural advances that improve classification accuracy, computing efficiency, and parameter optimisation by quantum. On medical imaging datasets like musculoskeletal imaging, parallel quantum computing architectures train 12 times quicker while keeping accuracy. Quantum hardware limits, noise resilience, scalability restrictions, and model interpretability are discussed in relation to clinical bone cancer screening implementation. Quantum transfer learning, federated quantum machine learning, and orthopaedic imaging-optimized hardware-aware quantum circuit design are future directions.
Deep learning techniques have significantly enhanced medical image classification for disease diagnosis. However, traditional deep learning models face several challenges, such as dependence on large annotated datasets, complex architectural layers, and millions of trainable parameters, which can increase computational load and cause overfitting. Although quantum computing offers potential for parallel processing and improved feature representation, its practical use is limited by the current capabilities of Noisy Intermediate-Scale Quantum (NISQ) hardware. To overcome these issues, Hybrid Quantum–Classical Convolutional Neural Networks (HQCNNs) have been developed, using quantum properties like superposition and entanglement to improve feature extraction and classification of medical images. This review offers a thorough analysis of 50 peer-reviewed studies published from 2021 to 2026 and introduces a taxonomy of HQCNN architectures. It classifies existing approaches into three categories: Quantum-to-Classical, Classical-to-Quantum, and Hybrid Quantum Transfer Learning. The studies reviewed encompass a diverse range of medical imaging applications, including binary and multi-class disease classification using X-ray, CT, MRI, ultrasound, dermoscopic, retinal, and mammographic images. Additionally, the review compares HQCNNs with their classical CNN counterparts, exploring how factors like quantum circuit design, dataset size, class imbalance, task complexity, evaluation protocols, and hardware limitations influence classification performance. It concludes with an analysis of the key limitations of current HQCNN models, discusses challenges in deploying NISQ devices practically, and proposes future research directions to bridge the gap between experimental HQCNN frameworks and reliable clinical diagnostic systems.
Quantum machine learning on noisy intermediate-scale quantum (NISQ) devices often suffers from noise sensitivity, small-data overfitting, and miscalibrated predictive confidence. We propose an uncertainty-aware hybrid Bayesian quantum neural network (BQNN) that couples a Bayesian convolutional front-end with a parameterized quantum circuit (PQC), forming a three-stage pipeline: Bayesian feature extraction, quantum state evolution, and classical decision making. For 28 ×28 grayscale inputs, the front-end uses an 8-filter 3 ×3 Bayesian convolution followed by 2 ×2 max-pooling and a fully connected layer to produce a 10-dimensional embedding, which is mapped to four rotation angles and encoded on 4 qubits. Two parameterized quantum circuit designs are considered for the quantum classification layer. On MNIST and Fashion-MNIST, repeated experiments over five independent random seeds show that the proposed BQNN variants consistently outperform the corresponding QCNN baselines. On MNIST, BQNN-2 achieves a mean best test accuracy of 95.46 ± 0.36%, a mean final test accuracy of 95.44 ± 0.38%, and a mean final test loss of 0.169 ± 0.012. On Fashion-MNIST, BQNN-1 attains the best mean overall performance, with a mean best test accuracy of 87.59 ± 0.62%, a mean final test accuracy of 87.49 ± 0.73%, and a mean final test loss of 0.385 ± 0.017, while BQNN-2 exhibits slightly smaller run-to-run variation. Additional representative comparisons with QNN baselines under the same training configuration further suggest faster convergence and higher peak accuracy for BQNN. Using 30 Monte-Carlo forward passes, BQNN achieves better calibration (ECE 0.007-0.009) than QCNN (ECE 0.016-0.020), thereby reducing overconfident predictions. Additional robustness experiments under noisy mixed-state simulation further show that, under depolarizing noise, BQNN consistently preserves higher peak test accuracy than QCNN across both circuit variants on MNIST, demonstrating improved robustness in NISQ-like noisy settings.
Medical image classification is a critical component of modern healthcare; however, accurate diagnosis remains challenging due to limited annotated datasets, class imbalance, and the high dimensionality of medical imaging data. To address these challenges, a hybrid quantum-classical neural network (HQCNN) is proposed, integrating classical deep learning with variational quantum learning for medical image classification. The proposed architecture combines a five-layer convolutional neural network (CNN) for hierarchical feature extraction with a lightweight 4-qubit variational quantum circuit (VQC) incorporating quantum state encoding, superposition and entanglement mechanisms, and a quantum attention-Fourier (QAF) module. This hybrid design aims to improve nonlinear feature representation and quantum parameter efficiency while maintaining a shallow quantum circuit suitable for noisy intermediate-scale quantum (NISQ)-era constraints. Experimental evaluation on six MedMNIST benchmark datasets demonstrated competitive performance across both binary and multi-class classification tasks. HQCNN achieved 98.88% accuracy on the binary subset of PathMNIST (classes 0 vs. 1), 97.61% accuracy on the multi-class OrganAMNIST dataset, and 86.29% accuracy on BreastMNIST. Comparative experiments and statistical analyses demonstrated consistent improvements over the controlled BHQNN baseline, while component-wise ablation studies showed that the QAF module, superposition and entanglement mechanisms, and expressive parameterized rotations contributed to classification performance in a complementary and dataset-dependent manner. Moreover, HQCNN reduced the number of trainable quantum parameters by approximately 55.6% compared with the baseline hybrid quantum neural network (BHQNN). Noise-aware simulations further showed that the model retained relatively stable predictive performance under moderate depolarizing noise, supporting further evaluation under near-term quantum computing conditions. Overall, the results demonstrate that HQCNN provides a parameter-efficient hybrid quantum-classical framework for medical image classification and offers a promising foundation for further investigation of quantum-enhanced medical image analysis.
Quantum machine learning has emerged as a promising approach to improve feature extraction and classification tasks in high-dimensional data domains such as medical imaging. In this work, we present a hybrid Quantum-Classical Convolutional Neural Network (QCNN) architecture designed for the binary classification of the BreastMNIST dataset, a standardized benchmark for distinguishing between benign and malignant breast tumors. Our architecture integrates classical convolutional feature extraction with two distinct quantum circuits: an amplitude-encoding variational quantum circuit (VQC) and an angle-encoding VQC circuit with circular entanglement, both implemented on four qubits. These circuits generate quantum feature embeddings that are fused with classical features to form a joint feature space, which is subsequently processed by a fully connected classifier. To ensure fairness, the hybrid QCNN is parameter-matched against a baseline classical CNN, allowing us to isolate the contribution of quantum layers. Both models are trained under identical conditions using the Adam optimizer and binary cross-entropy loss. Experimental evaluation in five independent runs demonstrates that the hybrid QCNN achieves statistically significant improvements in classification accuracy compared to the classical CNN, as validated by a one-sided Wilcoxon signed rank test (p = 0.03125) and supported by large effect size of Cohen's d = 2.14. Our results indicate that hybrid QCNN architectures can leverage entanglement and quantum feature fusion to enhance medical image classification tasks. This work establishes a statistical validation framework for assessing hybrid quantum models in biomedical applications and highlights pathways for scaling to larger datasets and deployment on near-term quantum hardware.
This paper presents a novel hybrid quantum-classical model for automated bone fracture detection and classification from radiographic images. By integrating quantum computing principles with convolutional neural networks, we demonstrate a system capable of achieving unprecedented accuracy in fracture detection. The proposed methodology leverages quantum-enhanced feature extraction while maintaining clinical deployment feasibility. Our approach utilizes a quantum-augmented VGG16 architecture with specialized quantum circuits designed to improve feature space exploration. with our hybrid model achieving 100% accuracy on the test dataset. This research establishes a new paradigm for medical image analysis that harnesses quantum computational advantages within existing classical frameworks.