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International Conference for Emerging Technology (INCET)

Automated Bone Fracture Classification Using a Hybrid Quantum-Classical Neural Network Approach

Praveen S, K. Maharajan, Prathapani Yuktesh, Pothuganti Yaswanth Guptha, Rangani Vinod Kumar

Published May 23, 2025• 1 citation
Publisher

Abstract

This paper presents a novel hybrid quantum-classical model for automated bone fracture detection and classification from radiographic images. By integrating quantum computing principles with convolutional neural networks, we demonstrate a system capable of achieving unprecedented accuracy in fracture detection. The proposed methodology leverages quantum-enhanced feature extraction while maintaining clinical deployment feasibility. Our approach utilizes a quantum-augmented VGG16 architecture with specialized quantum circuits designed to improve feature space exploration. with our hybrid model achieving 100% accuracy on the test dataset. This research establishes a new paradigm for medical image analysis that harnesses quantum computational advantages within existing classical frameworks.

DOI
10.1109/incet64471.2025.11140367

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Deep learning techniques have significantly enhanced medical image classification for disease diagnosis. However, traditional deep learning models face several challenges, such as dependence on large annotated datasets, complex architectural layers, and millions of trainable parameters, which can increase computational load and cause overfitting. Although quantum computing offers potential for parallel processing and improved feature representation, its practical use is limited by the current capabilities of Noisy Intermediate-Scale Quantum (NISQ) hardware. To overcome these issues, Hybrid Quantum–Classical Convolutional Neural Networks (HQCNNs) have been developed, using quantum properties like superposition and entanglement to improve feature extraction and classification of medical images. This review offers a thorough analysis of 50 peer-reviewed studies published from 2021 to 2026 and introduces a taxonomy of HQCNN architectures. It classifies existing approaches into three categories: Quantum-to-Classical, Classical-to-Quantum, and Hybrid Quantum Transfer Learning. The studies reviewed encompass a diverse range of medical imaging applications, including binary and multi-class disease classification using X-ray, CT, MRI, ultrasound, dermoscopic, retinal, and mammographic images. Additionally, the review compares HQCNNs with their classical CNN counterparts, exploring how factors like quantum circuit design, dataset size, class imbalance, task complexity, evaluation protocols, and hardware limitations influence classification performance. It concludes with an analysis of the key limitations of current HQCNN models, discusses challenges in deploying NISQ devices practically, and proposes future research directions to bridge the gap between experimental HQCNN frameworks and reliable clinical diagnostic systems.
Introduction: Medical image classification is a crucial task in cancer diagnosis, relying on the accurate analysis of high-dimensional imaging data. While Convolutional Neural Networks (CNNs) have shown great success in this domain, their performance is often limited by the shallow feature expressiveness and overfitting, particularly in small or heterogeneous datasets. Methods: Quantum machine learning offers new opportunities through high-dimensional representations and nonlinear transformations. In this work, we propose a Quantum-Enhanced Sandwich Convolutional Neural Network (QSCNN), a layered hybrid architecture that integrates quantum and classical modules. The model employs a quanvolutional layer for localized quantum feature extraction, followed by conventional convolution and pooling for hierarchical representation learning, and a variational quantum classifier for nonlinear decision-making. Results: QSCNN achieved higher accuracy and training stability than classical CNNs and QCCNN baselines across three medical imaging tasks.: brain tumor MRI, skin cancer dermoscopy, and lung cancer CT. Circuit depth analysis revealed a trade-off between expressiveness and robustness, and additional experiments with depolarizing noise confirmed the model’s resilience under realistic quantum error conditions. Discussion: This suggests that circuit design choices influence hybrid model behavior and generalization, supporting the feasibility of quantum-enhanced methods for small-sample medical imaging. However, the current evaluation is limited to relatively small benchmark datasets, and broader validation on large-scale data will be essential to confirm clinical applicability. Conclusion: In summary, QSCNN presents a feasible hybrid framework for enhancing medical image classification with quantum features. While preliminary, our results suggest potential advantages in accuracy and stability under NISQ conditions.