Recently, the utilization of real-world medical data collected from clinical sites has been attracting attention. Especially as the number of variables in real-world medical data increases, causal discovery becomes more and more effective. On the other hand, it is necessary to develop new causal discovery algorithms suitable for small data sets for situations where sample sizes are insufficient to detect reasonable causal relationships, such as rare diseases and emerging infectious diseases. This study aims to develop a new causal discovery algorithm suitable for a small number of real-world medical data using quantum computing, one of the emerging information technologies attracting attention for its application in machine learning. In this study, a new algorithm that applies the quantum kernel to a linear non-Gaussian acyclic model, one of the causal discovery algorithms, is developed. Experiments on several artificial data sets showed that the new algorithm proposed in this study was more accurate than existing methods with the Gaussian kernel under various conditions in the low-data regime. When the new algorithm was applied to real-world medical data, a case was confirmed in which the causal structure could be correctly estimated even when the amount of data was small, which was not possible with existing methods. Furthermore, the possibility of implementing the new algorithm on real quantum hardware was discussed. This study suggests that the new proposed algorithm using quantum computing might be a good choice among the causal discovery algorithms in the low-data regime for novel medical knowledge discovery.
Recently, the utilization of real-world medical data collected from clinical sites has been attracting attention. Especially as the number of variables in real-world medical data increases, causal discovery becomes more and more effective. On the other hand, it is necessary to develop new causal discovery algorithms suitable for small data sets for situations where sample sizes are insufficient to detect reasonable causal relationships, such as rare diseases and emerging infectious diseases. This study aims to develop a new causal discovery algorithm suitable for a small number of real-world medical data using quantum computing, one of the emerging information technologies attracting attention for its application in machine learning. In this study, a new algorithm that applies the quantum kernel to a linear non-Gaussian acyclic model, one of the causal discovery algorithms, is developed. Experiments on several artificial data sets showed that the new algorithm proposed in this study was more accurate than existing methods with the Gaussian kernel under various conditions in the low-data regime. When the new algorithm was applied to real-world medical data, a case was confirmed in which the causal structure could be correctly estimated even when the amount of data was small, which was not possible with existing methods. Furthermore, the possibility of implementing the new algorithm on real quantum hardware was discussed. This study suggests that the new proposed algorithm using quantum computing might be a good choice among the causal discovery algorithms in the low-data regime for novel medical knowledge discovery.
Quantum machine learning (QML) in the field of disease detection and prediction use quantum computing techniques and algorithms to analyze and classify large datasets of medical information, by identifying subtle patterns and predict the occurrence or progression of diseases. It involves applying machine learning techniques to data from biological and medical research, such as-genomic and proteomic data, medical imaging, electronic health records, and clinical trial data, using quantum computing algorithms and architectures to perform these analyses more efficiently and accurately than classical computing methods. This approach has the potential to provide new insights into complex biological systems and facilitate the development of more effective treatments and personalized medicine. In this paper, a systematic review of the use of QML algorithms has been conducted, which focuses on the detection and prediction of diseases among patients. The current essence of the field along with the challenges and limitations of current works have also been discussed. After evaluating the implemented and proposed methods of data analysis, algorithm development, usefulness and efficiency of the system in various disease detection and prediction, a recommendation was made on the open research scopes in this field at the end of the paper.
Quantum computing is fast transforming the medical world and giving it a new level of speed, accuracy, and safety in the health-care information. The latest developments use quantum machine learning and quantum-classical to improve medical imaging like classification, segmentation, and disease prediction, going beyond the capability of the classical algorithms. In the multifactorial disease cases, like cancer and neurological diseases, quantum-enhanced analytics will yield better clinical prognoses, better biomarker discoveries, and earlier detection. In the meantime, quantum-cryptography protocols are under development that will provide protection against privacy threats that are constantly changing to harm patient data. State-of-the-art quantum neural networks and adaptive hybrid quantum convolutional neural networks (CNNs) continue to optimize the process of diagnostics, reducing resource consumption, without losing the level of accuracy. This review maps these new applications, identifies the new trends, and talks about the future challenges of such applications, especially the requirement of explainable, interpretable quantum AI, which the clinicians can believe in. In brief, quantum technologies are in their infancy, but will have the ability to advance precision medicine, customised treatment and revolutionise medical decision-making.
Abstract Modern machine learning (ML) methods typically fail to adequately capture causal information. Consequently, such models do not handle data distributional shifts, are vulnerable to adversarial examples, and often learn spurious correlations (Schölkopf and von Kügelgen 2022 (arXiv:2204.00607) [cs.AI]). Causal ML, or causal inference, aims to solve these issues by estimating the expected outcome of counterfactual events, using observational and/or interventional data, where causal relationships are typically depicted as directed acyclic graphs. It is an open question as to whether these causal algorithms provide opportunities for quantum enhancement. In this paper we consider a recently developed family of non-parametric, continuous causal estimators and derive quantum algorithms for these tasks. Kernel evaluation and large matrix inversion are critical sub-routines of these classical algorithms, which makes them particularly amenable to a quantum treatment. Unlike other quantum ML algorithms, closed form solutions for the estimators exist, negating the need for gradient evaluation and variational learning. We describe several new hybrid quantum–classical algorithms and show that uniform consistency of the estimators is retained. Furthermore, if one is satisfied with a quantum state output that is proportional to the true causal estimand, then these algorithms inherit the exponential complexity advantages given by quantum linear system solvers.
Background Artificial Intelligence (AI) incorporation within healthcare applications has significantly helped in the improvement of healthcare diagnostics, patient forecasting, and clinical decision-making. The steady growing of medical data in terms of quantity, quality, and dimension poses more significant problems for traditional AI methods in terms of size, time, and computational efficiency. However, classical machine learning models often struggle with high-dimensional, imbalanced, and heterogeneous medical datasets, which limits their scalability and generalizability. The Quantum Artificial Intelligence (QAI) model, which combines quantum computing and machine learning in a complementary way, has emerged as one of the main trends to defeat these problems. This complementary approach is gaining more popularity, with the most advanced work being developed in this area, as it offers a fundamental explanation of current complexities and the underlying principles and their applications. Methodology This paper begins with the basic concepts of quantum computing and where it overlaps with AI. It then moves to a comparative approach, discussing various quantum machine learning algorithms such as quantum support vector machines, quantum neural networks, and variational quantum circuits. A comparative evaluation of quantum support vector machine, variational quantum classifier, quantum neural network, quantum K-means, and quantum Boltzmann machine is conducted using the Pima Indians Diabetes dataset to assess model behaviour and performance under standard metrics. Further detail is provided on the theoretical and practical implications of QAI in medical imaging, genomics, electronic health records, and drug discovery. Additionally, this paper examines platforms, tools, and quantum hardware used for QAI research, and discusses unique challenges currently faced in quantum technology. Results Unlike prior surveys that primarily provide conceptual overviews, this paper uniquely combines a comprehensive review with practical benchmarking of multiple quantum machine learning models on a benchmark medical dataset. This provides comparative insights into algorithmic performance under real-world constraints, particularly in relation to high-dimensional medical data, genomic data, electronic health records with large number of clinical attributes, radiology images, etc. In this study, dimensionality arises from multivariate clinical features encoded into quantum feature maps and the limitations of current quantum systems. Conclusion This paper aims to serve as a starting point for researchers and practitioners interested in the potential of quantum-enhanced AI to transform health data analytics. By identifying current limitations, evaluating the performance of emerging quantum machine learning approaches, and outlining gaps in the literature, the paper highlights future research directions necessary to advance QAI in healthcare. Overall, the findings outline both the potential and practical constraints of quantum models, offering a foundation for future work toward scalable, clinically applicable QAI solutions.
Quantum computing is quickly revolutionizing medicine, promising unprecedented levels of processing, analysis, and decision-making abilities. This review discusses recent developments in applying quantum computing to medical imaging, diagnostics, and treatment planning. Quantum machine learning and hybrid quantum-classical models have been used by researchers to show improved accuracy, speed, and scalability in medical image classification, segmentation, and disease prediction. Quantum-improved algorithms are being implemented for early detection of multifactorial diseases like cancer and neurologic disorders with potential for advancing clinical prognoses and biomarker discovery. Moreover, quantum cryptography methods are under development to enhance security for private medical information with concerns regarding expanding privacy and security risks. Improvements in quantum neural networks and adaptive hybrid quantum convolutional neural networks (CNNs) also hold promise in enhancing diagnostic efficiency and resource savings. This review synthesizes existing applications, identifies new trends, and delineates challenges and future directions of quantum computing in medicine. It underscores the importance of explainable and interpretable quantum AI systems to maintain clinical trust and utility. The results indicate that quantum technologies, although in their infancy, have transformative potential for precision medicine, personalized therapy, and sophisticated medical decision-making.
Disease hazard prediction has been transformed by the use of artificial intelligence in healthcare; however, there are still problems with striking a balance between interpretability and predictive routine, mostly when working with complex, high-dimensional clinical data. To improve the precision, scalability, and transparency of disease risk prediction, this work presents a novel Quantum-Enabled Explainable AI (QXAI) system that syndicates explainable machine learning with quantum computing. Through the use of quantum algorithms, explicitly quantum kernel methods and quantum-enhanced feature selection, the suggested system achieves huge electronic health record (EHR) datasets efficiently while addressing problems with non-linearity and data narrowness. This work uses explainable AI methods like SHAP and counterfactual reasoning to guarantee interpretability, allowing doctors to understand the reasoning behind predictions. Real-world medical datasets are used for a thorough evaluation, which shows that the QXAI system finishes better than traditional baselines in terms of prediction accuracy, model robustness, and explanation reliability. In the end, this paper places the foundation for the implementation of reliable, quantum-assisted decision support systems in medical practice, which will lead to more personalized, reasonable, and knowledgeable healthcare.