An entanglement-enhanced microscope

Craig Price, Qi Liu, Nathan Gemelke

Jun Liu, Xiaolong Su

Microscopes are indispensable tools in modern biology and medicine.With the development of microscopy, the signal-tonoise ratio of microscopes is now limited by the shot noise.Recently, quantum-enhanced microscopic imaging provides a feasible approach for improving the signal-to-noise ratio since it can beat the shot-noise limit by using quantum light.In this review, we first briefly introduce quantum states applied in quantum-enhanced microscopic imaging, and then we provide an overview of the principle and progress of quantum-enhanced stimulated Raman scattering microscopy, entangled twophoton microscopy, and quantum-enhanced differential interference contrast microscopy.

Jincheng Zhang

This paper investigates the coupling of microscopic dynamics and quantum entanglement, aiming to develop a novel micro-domain dynamics model that leverages quantum entanglement to enhance computational efficiency and accuracy. The model seeks to represent and simulate complex systems exhibiting intricate behavior driven by the interplay between microscopic forces and quantum phenomena. This research explores the potential of incorporating quantum entanglement into traditional micro-domain simulations, focusing on the optimization of computational pathways and the enhancement of model fidelity. The core claim is that this approach offers a significant advancement over conventional methods by effectively incorporating quantum entanglement, leading to improved simulation capabilities.

Nicolas Regnault

Oleg P. Varnavski, Carolyn E. Gunthardt, Aasia O. Rehman +2 more

Correct biological interpretation from cell imaging can be achieved only if the observed phenomena proceed with negligible perturbation from the imaging system. Herein, we demonstrate microscopic images of breast cancer cells created by the fluorescence selectively excited in the process of entangled two-photon absorption in a scanning microscope at an excitation intensity orders of magnitude lower than that used for classical two-photon microscopy. Quantum enhanced entangled two-photon microscopy has shown cell imaging capabilities at an unprecedented low excitation intensity of ∼3.6 × 10 7 photons/s, which is a million times lower than the excitation level for the classical two-photon fluorescence image obtained in the same microscope. The extremely low light probe intensity demonstrated in entangled two-photon microscopy is of critical importance to minimize photobleaching during repetitive imaging and damage to cells in live-cell applications. This technology opens new avenues in cell investigations with light microscopy, such as enhanced selectivity and time–frequency resolution.

Manuel Endres, Leonardo Mazza, Davide Rossini +6 more