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The future of cryptographic algorithm development for intelligent healthcare systems

Andriy Horpenyuk, Olha Partyka, Agbotiname Lucky Imoize

Published Oct 27, 2026• 0 citations
Publisher

Abstract

Classical asymmetric cryptographic algorithms have formed the basis of modern cybersecurity protocols across many application areas, including intelligent healthcare systems. For decades, these algorithms have provided effective solutions for ensuring the confidentiality, authenticity, integrity and non-repudiation of information. However, asymmetric cryptographic algorithms rely on mathematical problems with empirically established (but unproven) computational hardness. The development of quantum computing algorithms capable of breaking these classical cryptosystems has created a well-recognised threat to the entire existing cybersecurity infrastructure. In response, national and international standardisation bodies have initiated the development and competitive selection of new, post-quantum cryptographic algorithms. The first such algorithms have already been standardised by the National Institute of Standards and Technology (NIST). However, the standardisation process is only the beginning of a much more complex, resource-intensive practical implementation. This chapter analyses recent advances in post-quantum cryptographic algorithms and their relevance to intelligent healthcare systems. It examines modern cryptographic approaches to healthcare data protection, identifies the main barriers to post-quantum migration in healthcare environments and proposes improvements in computational efficiency for basic cryptographic operations.

DOI
10.1049/pbhe070g_ch10

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Classical asymmetric cryptographic algorithms have formed the basis of modern cybersecurity protocols across many application areas, including intelligent healthcare systems. For decades, these algorithms have provided effective solutions for ensuring the confidentiality, authenticity, integrity and non-repudiation of information. However, asymmetric cryptographic algorithms rely on mathematical problems with empirically established (but unproven) computational hardness. The development of quantum computing algorithms capable of breaking these classical cryptosystems has created a well-recognised threat to the entire existing cybersecurity infrastructure. In response, national and international standardisation bodies have initiated the development and competitive selection of new, post-quantum cryptographic algorithms. The first such algorithms have already been standardised by the National Institute of Standards and Technology (NIST). However, the standardisation process is only the beginning of a much more complex, resource-intensive practical implementation. This chapter analyses recent advances in post-quantum cryptographic algorithms and their relevance to intelligent healthcare systems. It examines modern cryptographic approaches to healthcare data protection, identifies the main barriers to post-quantum migration in healthcare environments and proposes improvements in computational efficiency for basic cryptographic operations.
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The increasing digitalization of the healthcare system, driven by electronic health records, medical IoT devices, and AI-aided diagnostics, has significantly expanded the attack surface for cyber threats. Although current cryptographic protocols provide sufficient security against classical adversaries, new developments in quantum computing threaten the confidentiality, integrity, and availability of medical information as never before. Shor’s algorithm could break widely used asymmetric encryption systems, and Grover’s algorithm weakens symmetric ones, which could render modern healthcare security systems obsolete. This review provides an in-depth and organized analysis of the evolving quantum threat environment in healthcare ecosystems and of the need to move toward quantum-resilient security architectures. It synthesizes the existing literature on post-quantum cryptography (PQC) and identifies lattice-based, hash-based, multivariate, and code-based algorithms as potentially viable long-term replacements. Moreover, it examines the cybersecurity issues that quantum-enabled attacks pose to medical IoT systems, clinical decision-support systems, wearable sensors, telemedicine systems, and cloud-based health information exchanges. The review also covers hybrid quantum-classical defenses, quantum key distribution (QKD), quantum random number generation (QRNG), and blockchain-based trust systems that aim to make systems resilient to advanced persistent quantum attacks. This paper identifies key gaps and outlines future research directions for developing quantum-secure medical systems. The results highlight the importance of early adoption of PQC standards and a layered cyber defense approach to protect patient privacy, ensure regulatory compliance, and retain trust in next-generation digital medical data communication.