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Quantum-Enhanced Deep Learning framework for Early Detection of Neurodegenerative Disorders

D. Stalin David, D. David Neels Ponkumar, Anurag Sharma, Sivanesan Bala Krishnan, Prąsun Chakrabarti

Published Mar 31, 2026• 0 citations
Publisher

Abstract

© 2026, Dr. Yashwant Research Labs Pvt. Ltd. All rights reserved.The presented investigation opens up a novel avenue that fuses quantum-assisted deep learning algorithms for the detection at the earliest possible stage of neurodegenerative diseases. The system that unites the pattern recognition capabilities of deep learning and the quantum computing power is aimed at greatly improving the diagnostic accuracy for the initial stages. This method highlights the exploitation of hybrid quantum-classical architectures to execute the complicated and multidimensional medical dataset that captures subtle interrelationship and disturbances that may not be revealed by the traditional models. The synthesis of the quantum feature encoding with the neural architectures that become more sophisticated provides for quicker convergence and better generalization over the various patient sets of data. Also, the model contains a changeable learning method that gets the current clinical patterns and, consequently, be able to timely and more accurately. The innovative architecture not only improves the prediction results but also facilitates the development of more scalable and energy-efficient solutions in the area of neuroinformatics...

DOI
10.25405/ncl.34545030

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© 2026, Dr. Yashwant Research Labs Pvt. Ltd. All rights reserved.The presented investigation opens up a novel avenue that fuses quantum-assisted deep learning algorithms for the detection at the earliest possible stage of neurodegenerative diseases. The system that unites the pattern recognition capabilities of deep learning and the quantum computing power is aimed at greatly improving the diagnostic accuracy for the initial stages. This method highlights the exploitation of hybrid quantum-classical architectures to execute the complicated and multidimensional medical dataset that captures subtle interrelationship and disturbances that may not be revealed by the traditional models. The synthesis of the quantum feature encoding with the neural architectures that become more sophisticated provides for quicker convergence and better generalization over the various patient sets of data. Also, the model contains a changeable learning method that gets the current clinical patterns and, consequently, be able to timely and more accurately. The innovative architecture not only improves the prediction results but also facilitates the development of more scalable and energy-efficient solutions in the area of neuroinformatics...
A novel technique in early Parkinson's disease diagnosis with the use of a quantum long short-term memory model is described in this paper. Quantum computing, therefore, coupled with deep learning, seeks to improve the accuracy as well as efficiency of classifying traditional LSTM models, which even becomes more critical in cases of neurodegenerative diseases like Parkinson's disease, where diagnostics at an early stage would be helpful. The model was tested heavily on public datasets and compared with traditional deep learning models, which were significantly outperformed by this model with its superior accuracy and precision and recall rates. Furthermore, the computation time hugely became lower and thus possibly may revolutionize diagnostic procedures. These innovations will eventually establish quantum machine learning in medicine at a more accurate and faster diagnosis pace. Future development will focus on expanding the quantum LSTM so it can be more generally applicable to various situations for other medical conditions. Researchers believe that the configuration of the quantum layers should be modified, and this model will be extended to other deep learning models to have a more comprehensive and versatile tool in diagnosis for Parkinson's disease and perhaps other medical uses. The ultimate vision in the long term would be to use quantum-based models, not only for early detection but also improvement in prediction and personalization of treatment to revolutionize health care and thereby improve patient outcomes with neurodegenerative diseases.
Quantum-Enhanced Machine Learning (QEML) is a new computational paradigm that introduces the concept of quantum mechanics with the latest artificial intelligence algorithms to enhance the performance of the diagnostic process in the field of medical imaging. The early identification of diseases is crucial in mortality reduction and improving patient outcome, especially in capacities dealing with such diseases as cancer, neurological diseases, heart diseases, and infections of the lungs. Although conventional deep learning architectures, in particular, Convolutional Neural Networks (CNNs) have been highly successful in processing complex medical images such as MRI scans, CT images, X-rays, and histopathological data, they can be computationally expensive, need large data sets, and suffer in optimization of high dimensional feature spaces. The limitations that QEML tries to overcome are based on the quantum mechanical principles of superposition, entanglement and interference to facilitate better data representation and processing. The suggested structure is based on the classical deep learning architectures and variational quantum circuits together, to create a hybrid quantum-classical system, which improves features extraction and classification levels. Under this method, the classical image characteristics are coded into quantum states and processed in high-dimensional Hilbert spaces, which can enhance the separability of subtle disease patterns, which would have otherwise been challenging to obtain with conventional techniques. The objective of this hybrid system is to enhance the critical diagnostic measures like sensitivity and specificity without affecting the interpretability of such measures to be used in the clinical context. The proposed framework is also assessed in terms of its feasibility, its computational performance and scalability to the capabilities of present-day Noisy Intermediate-Scale Quantum (NISQ) devices. The model effectiveness is evaluated using objective evaluation metrics, which, in a way, guarantee the feasibility of the model application within a real-life healthcare context. On balance, quantum computing and medical image analysis integration is an exciting field of work of the future intelligent healthcare systems and has a potential of providing more efficient, accurate, and scalable diagnostic solutions.
The rapid advancements in artificial intelligence (AI) and quantum computing have catalyzed an unprecedented shift in the methodologies utilized for healthcare diagnostics and treatment optimization. This research paper explores the integration of quantum neural networks (QNNs) with classical machine learning (ML) algorithms to enhance diagnostic accuracy, facilitate personalized treatment plans, and predict patient outcomes with a higher degree of precision. Quantum neural networks, leveraging the principles of quantum mechanics such as superposition, entanglement, and quantum parallelism, have demonstrated the potential to perform complex computations more efficiently than classical counterparts. When coupled with established machine learning algorithms, QNNs can overcome traditional limitations in data processing, enabling more sophisticated models capable of uncovering intricate patterns in large and high-dimensional datasets. Machine learning, with its vast applications in the medical field, has long been instrumental in improving diagnostics and tailoring treatment regimens to patient-specific characteristics. However, despite significant advancements, classical ML approaches face substantial challenges, particularly in terms of computational complexity and the ability to process large-scale, multi-modal healthcare data effectively. Quantum neural networks address these challenges by introducing quantum computational paradigms that facilitate exponentially faster processing, allowing for real-time analysis of vast and complex datasets. The synergy between QNNs and ML algorithms introduces novel approaches that are poised to revolutionize predictive analytics in healthcare, optimizing patient outcomes and enabling highly personalized treatment plans. A key aspect of integrating quantum neural networks into machine learning frameworks is the potential for improved precision in diagnostic systems. Traditional diagnostic procedures often rely on predefined models that may overlook nuanced correlations within patient data. Quantum neural networks, with their ability to represent and process data in a quantum space, provide a more robust framework that can adaptively learn from intricate relationships in patient information. For instance, QNNs can significantly enhance the efficacy of disease detection algorithms, such as those used for identifying early-stage cancers or predicting the onset of chronic conditions like diabetes and heart disease, by offering superior pattern recognition capabilities. Furthermore, QNNs combined with classical machine learning architectures facilitate the creation of hybrid models that harness the strengths of both approaches, leading to diagnostic tools that are not only more precise but also more adaptive to varied data sources. The integration of QNNs with machine learning extends beyond diagnostics to personalized treatment optimization. Traditional treatment planning methodologies, including rule-based and data-driven ML models, often face difficulties in accounting for the multifaceted nature of patient data and individual variability. Quantum neural networks enhance this process by leveraging quantum algorithms that provide an efficient search space for complex treatment optimization problems, allowing for a more detailed understanding of patient responses and potential treatment outcomes. The ability of QNNs to perform parallel processing enables the assessment of a wide range of treatment scenarios simultaneously, leading to more accurate predictions regarding patient reactions to specific drugs, therapies, or medical interventions. This facilitates an adaptive approach that can recommend personalized treatment regimens based on comprehensive patient profiles, ultimately enhancing patient outcomes and reducing the likelihood of adverse drug reactions. In addition to enhancing diagnostics and treatment recommendations, quantum neural networks show promise in forecasting patient outcomes by offering a more robust analysis of longitudinal patient data. Forecasting models that leverage the combined power of quantum and classical algorithms can process historical data more rapidly, allowing healthcare providers to anticipate potential health issues and intervene earlier. For example, predictive models utilizing QNNs can anticipate patient deterioration in critical care settings, facilitating timely interventions that mitigate risks and improve survival rates. Such predictive models can be instrumental in managing chronic diseases, monitoring recovery trajectories, and optimizing resource allocation within healthcare systems, thus contributing to overall efficiency and better resource management. Despite the promising capabilities of integrating QNNs with ML algorithms, there are notable challenges that need to be addressed to fully realize their potential. The practical implementation of quantum algorithms in a healthcare context faces hurdles related to hardware limitations, the need for high fidelity in quantum states, and the scalability of quantum systems to handle real-world clinical data. Additionally, the hybrid nature of combining classical and quantum approaches requires sophisticated algorithms that can bridge the gap between quantum computation and classical data processing pipelines. Solutions to these challenges may include advancements in quantum hardware, such as the development of more stable qubits and noise reduction techniques, as well as the optimization of hybrid algorithms that leverage both classical machine learning and quantum computing capabilities effectively. The exploration of quantum neural networks for healthcare applications also necessitates rigorous ethical considerations, particularly in ensuring data privacy and security. The incorporation of quantum computing must comply with healthcare data protection regulations, and quantum algorithms must be designed to maintain patient confidentiality while processing sensitive health data. Moreover, the interpretability of quantum models poses challenges that could hinder their acceptance in clinical practice. Advances in explainable AI and quantum algorithm transparency are crucial to foster trust among healthcare professionals and patients alike. Integration of quantum neural networks with classical machine learning models represents a transformative approach that could significantly advance healthcare diagnostics, personalized treatment strategies, and patient outcome prediction. By harnessing the computational advantages offered by quantum systems and the flexibility of machine learning algorithms, healthcare applications can achieve a new level of precision and adaptability. Despite current challenges, continued research into quantum algorithms, quantum hardware development, and hybrid computational models promises substantial strides in overcoming these limitations. The synergy between QNNs and ML algorithms could ultimately lead to more effective, personalized, and efficient healthcare solutions, ushering in a new era of data-driven medical care characterized by increased diagnostic accuracy and improved treatment outcomes. As the field evolves, interdisciplinary collaboration between quantum physicists, computer scientists, and healthcare professionals will be vital to unlock the full potential of these innovative computational techniques and bring them to mainstream clinical use.
Alzheimer's disease (AD) presents significant diagnostic challenges owing to the subtle morphological similarities observed in the early stages, with traditional deep learning approaches often struggling to distinguish between the various stages of disease progression via structural Magnetic Resonance Imaging (MRI) data. Quantum computing offers unique advantages for medical image analysis, leveraging superposition and entanglement capabilities to process high-dimensional feature spaces beyond the limits of classical computation. This study introduces a hybrid quantum-classical neural network architecture (HQC-Net) for accurate four-class Alzheimer's disease classification, which uses quantum processing to detect patterns that are often invisible to classical spatial analysis methods. The proposed framework integrates classical feature extractors, including a custom CNN and modified ResNet18, with six-qubit variational quantum circuits that employ multiaxis rotation encoding (RY→RZ→RX), a quantum Fourier transform for spectral decomposition, and multihead attention for effective quantum-classical feature fusion. Comprehensive evaluations were conducted on the Kaggle dataset (5,121 samples) and the OASIS dataset (20,000 samples), incorporating realistic quantum noise modelling, including depolarising, amplitude damping, and phase damping channels. The modified QResNet18 configuration achieved a test accuracy of 99.67%, with perfect discriminative capability (AUC = 1.0000) on the OASIS dataset. Quantum processing demonstrated superior detection of very mild dementia (99.86% accuracy), which is crucial for early intervention. The proposed approach outperformed existing quantum-enhanced methods by 3.57 percentage points while effectively handling the increased diagnostic complexity associated with four-class classification. This study demonstrates a practical quantum advantage for multiclass neuroimaging classification, achieving superior diagnostic accuracy while maintaining computational efficiency and clinical deployment feasibility under current Noisy Intermediate-Scale Quantum (NISQ) hardware constraints.
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The synergy between quantum computing and deep learning holds revolutionary promise in facilitating smart healthcare by addressing problems in predictive diagnosis, realtime patient tracking, and personalized therapy. Deep learning algorithms such as CNNs and RNNs have scalability and efficiency limitations in processing clinical data with high dimensionality. Their limitations can be addressed by quantum computing through an inbuilt parallelism. This work suggests that Quantum-Enhanced Deep Learning for Smart Healthcare (QEDL-Health) should marry classical deep learning with quantum algorithms to revamp paradigms in healthcare. QEDL-Health applies quantum neural networks (QNNs) with quantum gates (Pauli-X, Hadamard, CNOT) to perform encoding and feature extraction efficiently. Model parameters are trained by quantum variational circuits (QVCs), while quantum support vector machines (QSVMs) diagnose diseases with better accuracy. IoT-generated vitals in real-time tracking are processed by quantum principal component analysis (QPCA), while personalized treatment is created by quantum approximate optimization algorithms (QAOAs). The system applies quantum Fourier transforms (QFTs) and Grover’s search algorithm to process efficiently. Experimental results in MIMIC-III, TCGA, and COVID-19 datasets confirm dominance by improving diagnostic correctness by 15% while computation time is decreased by 40% in genomic data processing compared to classical methods. Experimental results confirm that comparative evaluation establishes that conventional methods in deep learning have scalability limitations in efficiency and performance in intricate tasks in disease detection (such as cancer) and in tracking in real-time. This work bridges quantum computing with AI to lay the foundations for developing efficient, scalable, and intelligent healthcare systems to detect diseases earlier in time to reduce costs and improve patient outcomes.