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International Conference on Innovations in Mechanical, Robotics, Computing and Biomedical Engineering (ICIMRBE)

Quantum Contrastive Representation Learning Model for Label Efficient Medical Image Classification

Srinivasan M, Ali Hussein Ali Abu Zaid, V.Meera, Rajini Parimala, S. Agnes Shifani, Karthic Mohan

Published Aug 1, 2026• 0 citations
Publisher
DOI
10.1109/icimrbe70745.2026.11710114

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In the evolving landscape of data privacy regulations, the challenge of providing extensive data for robust deep classification models arises. The accuracy of these models relies on the amount of training data, due to the multitude of parameters that require tuning. Unfortunately, obtaining such ample data proves challenging, particularly in domains like medical applications, where there is a pressing need for robust models for early disease detection but a shortage of labeled data. Nevertheless, the classical supervised contrastive learning models, have shown the potential to address this challenge up to a certain limit, by utilizing deep encoder models. However, recent advancements in quantum machine learning enable the extraction of meaningful representations from extremely limited and simple data. Thus, replacing classical counterparts in classical or hybrid quantum-classical supervised contrastive models enhances feature learning capability with minimal data. Therefore, this work proposes the Q-SupCon model, a fully quantum-powered supervised contrastive learning model comprising a quantum data augmentation circuit, quantum encoder, quantum projection head, and quantum variational classifier, enabling efficient image classification with minimal labeled data. Furthermore, the novel model attains 80%, 60%, and 80% test accuracy on MNIST, KMNIST, and FMNIST datasets, marking a significant advancement in addressing the data scarcity challenge.
Noisy-label learning in small-scale medical image classification is challenging and hinders the superiority of deep neural networks. Recent studies suggest that quantum neural networks (QNNs) have shown potential in limited-data regimes, yet their use for noisy-label learning remains under-explored. A key obstacle is QNNs' intrinsic "natural smoothness", which may regularize training but also obscure high-confidence samples needed for noise-transition estimation. We propose Supermartingale-based Label Transition (SLT), an anchor-free loss correction framework for robust QNN-based medical image classification under noisy labels. SLT models entropy reduction in predictive distributions as a supermartingale and uses its monotonic behavior to identify stable transition-matrix refinement steps. This enables dynamic transition updates while reducing noise-driven oscillations during QNN training. We further provide a convergence analysis showing that the proposed transition-refinement process reaches a steady state. Experiments on multiple public small-scale medical image datasets demonstrate that SLT consistently improves QNN-based classification and stably outperforms classic noise-label learning baselines under synthetic and real-world label noise.
Medical image classification has been a fundamental task in computer-aided diagnosis. In this work, we propose a hybrid quantum-classical deep learning framework that integrates a parameterized quantum layer into the ResNet-18 architecture for medical image classification. Our experiments are conducted on the OrganMNIST-Axial, OrganMNIST-Coronal, and OrganMNIST-Sagittal datasets from the MedMNIST v2 collection, each consisting of 28×2828 \times 2828×28 grayscale images representing different organ sections. The quantum layer is implemented as a 6-qubit variational quantum circuit (VQC) that partially replaces the classical fully connected module, enabling the network to exploit quantum feature mapping and entanglement for enhanced nonlinear representation learning. This architectural modification reduces the number of classical trainable parameters by approximately 44% compared with the original ResNet-18 while preserving its representational capacity. We evaluate the proposed QResNet18 against classical baselines to investigate its potential advantages in terms of accuracy, robustness, and parameter efficiency. Experimental results demonstrate that the hybrid quantum-classical model achieves competitive or superior performance while maintaining a significantly reduced parameter count, highlighting the feasibility and promise of quantumenhanced medical image classification.