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International Conference on Cognitive Computing and Networking Systems (ICC-CNS)

Hybrid Quantum-Classical Neural Networks for Medical Image Diagnosis

Mayank Genwa

Published Jun 1, 2026• 0 citations
Publisher
DOI
10.1109/icc-cns70518.2026.11605991

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Medical image classification is a critical component of modern healthcare; however, accurate diagnosis remains challenging due to limited annotated datasets, class imbalance, and the high dimensionality of medical imaging data. To address these challenges, a hybrid quantum-classical neural network (HQCNN) is proposed, integrating classical deep learning with variational quantum learning for medical image classification. The proposed architecture combines a five-layer convolutional neural network (CNN) for hierarchical feature extraction with a lightweight 4-qubit variational quantum circuit (VQC) incorporating quantum state encoding, superposition and entanglement mechanisms, and a quantum attention-Fourier (QAF) module. This hybrid design aims to improve nonlinear feature representation and quantum parameter efficiency while maintaining a shallow quantum circuit suitable for noisy intermediate-scale quantum (NISQ)-era constraints. Experimental evaluation on six MedMNIST benchmark datasets demonstrated competitive performance across both binary and multi-class classification tasks. HQCNN achieved 98.88% accuracy on the binary subset of PathMNIST (classes 0 vs. 1), 97.61% accuracy on the multi-class OrganAMNIST dataset, and 86.29% accuracy on BreastMNIST. Comparative experiments and statistical analyses demonstrated consistent improvements over the controlled BHQNN baseline, while component-wise ablation studies showed that the QAF module, superposition and entanglement mechanisms, and expressive parameterized rotations contributed to classification performance in a complementary and dataset-dependent manner. Moreover, HQCNN reduced the number of trainable quantum parameters by approximately 55.6% compared with the baseline hybrid quantum neural network (BHQNN). Noise-aware simulations further showed that the model retained relatively stable predictive performance under moderate depolarizing noise, supporting further evaluation under near-term quantum computing conditions. Overall, the results demonstrate that HQCNN provides a parameter-efficient hybrid quantum-classical framework for medical image classification and offers a promising foundation for further investigation of quantum-enhanced medical image analysis.
Medical image classification is considered as very important field of diagnosis and treatment of neurological disorders, which include stroke, tumors, and hemorrhages, it can used to facilitate timely medical intervention. A hybrid quantum-classical convolutional neural network (QCNN) is presented by combining quantum information processing with classical deep learning techniques for improved feature extraction and classification accuracy. The model combines convolutional neural network (CNN), which handles initial feature extraction with a PennyLane and TensorFlow based layer that employs quantum entanglement and superposition principles to enhance classification performance. The model is trained and tested over a computed tomography (CT) scan image dataset which has four classes (normal, stroke, tumor, and hemorrhage). Various learning rates are tested and employed a hybrid backpropagation method to improve efficiency. Confusion matrices, region of conversion receiver operating characteristic (ROC) curves, and plots for the training convergence that all pointed to promising classification accuracy were derived with a detailed analysis accordingly. Overall, the results indicate that combining quantum computing with deep learning architectures could improve classification performance at a lowest computational cost. The results suggest the viability of hybrid quantum-classical models for medical imaging applications and indicate that quantum computing is a promising direction for enhancing diagnostic accuracy in the area of radiology.